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Showing content from https://pubmed.ncbi.nlm.nih.gov/18506026/ below:

Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group

. 2008 Jul 20;26(21):3552-9. doi: 10.1200/JCO.2007.13.9030. Epub 2008 May 27. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group Hélène Tribodet, Giorgio V Scagliotti, Jean-Yves Douillard, Frances A Shepherd, Richard J Stephens, Ariane Dunant, Valter Torri, Rafael Rosell, Lesley Seymour, Stephen G Spiro, Estelle Rolland, Roldano Fossati, Delphine Aubert, Keyue Ding, David Waller, Thierry Le Chevalier; LACE Collaborative Group

Collaborators, Affiliations

Collaborators

LACE Collaborative Group: Jean-Yves Douillard, Patricia His, Thierry Le Chevalier, Jean-Pierre Pignon, Giorgio V Scagliotti, Lesley Seymour, Frances A Shepherd, Stephen G Spiro, Richard J Stephens, Valter Torri, Hélène Tribodet, Bengt Bergman, Lucio Crino, Mario De Lena, Keyue Ding, Jean-Yves Douillard, Ariane Dunant, Roldano Fossati, Nicole Gower, Delphine Aubert, Thierry Le Chevalier, Jean-Pierre Pignon, Rafael Rosell, Giorgio V Scagliotti, Lesley Seymour, Frances A Shepherd, Stephen G Spiro, Richard J Stephens, Valter Torri, David Valter, Timothy Winton

Affiliation

¹ Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France. jppignon@igr.fr

PMID: 18506026
DOI: 10.1200/JCO.2007.13.9030

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Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group

Jean-Pierre Pignon et al. J Clin Oncol. 2008.

. 2008 Jul 20;26(21):3552-9. doi: 10.1200/JCO.2007.13.9030. Epub 2008 May 27. Authors Jean-Pierre Pignon¹, Hélène Tribodet, Giorgio V Scagliotti, Jean-Yves Douillard, Frances A Shepherd, Richard J Stephens, Ariane Dunant, Valter Torri, Rafael Rosell, Lesley Seymour, Stephen G Spiro, Estelle Rolland, Roldano Fossati, Delphine Aubert, Keyue Ding, David Waller, Thierry Le Chevalier; LACE Collaborative Group Collaborators

LACE Collaborative Group: Jean-Yves Douillard, Patricia His, Thierry Le Chevalier, Jean-Pierre Pignon, Giorgio V Scagliotti, Lesley Seymour, Frances A Shepherd, Stephen G Spiro, Richard J Stephens, Valter Torri, Hélène Tribodet, Bengt Bergman, Lucio Crino, Mario De Lena, Keyue Ding, Jean-Yves Douillard, Ariane Dunant, Roldano Fossati, Nicole Gower, Delphine Aubert, Thierry Le Chevalier, Jean-Pierre Pignon, Rafael Rosell, Giorgio V Scagliotti, Lesley Seymour, Frances A Shepherd, Stephen G Spiro, Richard J Stephens, Valter Torri, David Valter, Timothy Winton

Affiliation

¹ Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France. jppignon@igr.fr

PMID: 18506026
DOI: 10.1200/JCO.2007.13.9030

Item in Clipboard

Abstract

Purpose: Several recent trials have shown a significant overall survival (OS) benefit from postoperative cisplatin-based chemotherapy in patients with non-small-cell lung cancer (NSCLC). The aim of the Lung Adjuvant Cisplatin Evaluation was to identify treatment options associated with a higher benefit or groups of patients who particularly benefit from postoperative chemotherapy.

Patients and methods: Individual patient data were collected and pooled from the five largest trials (4,584 patients) of cisplatin-based chemotherapy in completely resected patients that were conducted after the 1995 NSCLC meta-analysis. The interactions between patient subgroups or treatment types and chemotherapy effect on OS were analyzed using hazard ratios (HRs) and log-rank tests stratified by trial.

Results: With a median follow-up time of 5.2 years, the overall HR of death was 0.89 (95% CI, 0.82 to 0.96; P = .005), corresponding to a 5-year absolute benefit of 5.4% from chemotherapy. There was no heterogeneity of chemotherapy effect among trials. The benefit varied with stage (test for trend, P = .04; HR for stage IA = 1.40; 95% CI, 0.95 to 2.06; HR for stage IB = 0.93; 95% CI, 0.78 to 1.10; HR for stage II = 0.83; 95% CI, 0.73 to 0.95; and HR for stage III = 0.83; 95% CI, 0.72 to 0.94). The effect of chemotherapy did not vary significantly (test for interaction, P = .11) with the associated drugs, including vinorelbine (HR = 0.80; 95% CI, 0.70 to 0.91), etoposide or vinca alkaloid (HR = 0.92; 95% CI, 0.80 to 1.07), or other (HR = 0.97; 95% CI, 0.84 to 1.13). Chemotherapy effect was higher in patients with better performance status. There was no interaction between chemotherapy effect and sex, age, histology, type of surgery, planned radiotherapy, or planned total dose of cisplatin.

Conclusion: Postoperative cisplatin-based chemotherapy significantly improves survival in patients with NSCLC.

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