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Showing content from https://pubmed.ncbi.nlm.nih.gov/18448996/ below:

The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th Edition of the TNM Classification of Malignant Tumors and the proposals for the 7th Edition

Collaborators, Affiliations

• International Staging Committee and Participating Institutions: P Goldstraw, H Asamura, D Ball, V Bolejack, E Brambilla, P A Bunn, D Carney, K Chansky, T Le Chevalier, J Crowley, R Ginsberg, D Giroux, P Groome, H H Hansen, P Van Houtte, J-G Im, H Kato, C Kennedy, M Krasnik, J van Meerbeeck, T Naruke, E F Patz, P E Postmus, R Rami-Porta, V Rusch, J P Sculier, Z Shaikh, F A Shepherd, Y Shimosato, L Sobin, W Travis, M Tsuboi, R Tsuchiya, E Vallieres, J Vansteenkiste, Yoh Watanabe, H Yokomise

• ¹ Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium. sculier@bordet.be

• PMID: 18448996
• DOI: 10.1097/JTO.0b013e31816de2b8

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Jean-Paul Sculier et al. J Thorac Oncol. 2008 May.

• International Staging Committee and Participating Institutions: P Goldstraw, H Asamura, D Ball, V Bolejack, E Brambilla, P A Bunn, D Carney, K Chansky, T Le Chevalier, J Crowley, R Ginsberg, D Giroux, P Groome, H H Hansen, P Van Houtte, J-G Im, H Kato, C Kennedy, M Krasnik, J van Meerbeeck, T Naruke, E F Patz, P E Postmus, R Rami-Porta, V Rusch, J P Sculier, Z Shaikh, F A Shepherd, Y Shimosato, L Sobin, W Travis, M Tsuboi, R Tsuchiya, E Vallieres, J Vansteenkiste, Yoh Watanabe, H Yokomise

• ¹ Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium. sculier@bordet.be

• PMID: 18448996
• DOI: 10.1097/JTO.0b013e31816de2b8

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Purpose: To identify, in the international staging database of the International Association for the Study of Lung Cancer, those prognostic factors that were significant and independent of clinical stage.

Material and methods: From the data submitted to the staging data base concerning 100,869 patients, cases were selected for which all the following variables were available: clinical stage, age, gender, performance status (PS), and histologic cell types. For non-small cell lung cancer (NSCLC), 12,428 patients were assessable, and for SCLC, 6609 patients were available for this study. Methods used were Cox regression analyses and recursive partitioning and amalgamation analyses.

Results: PS appeared to be a very important prognostic factor for survival in addition to clinical stage. Age and gender were other independent significant variables; For NSCLC and SCLC separately, recursive partitioning and amalgamation allowed the identification of four groups of patients with differing prognoses. In advanced NSCLC (stage IIIB / IV), some routine laboratory tests (mainly white blood cells and hypercalcaemia) were also found to be significant prognostic variables. In SCLC, albumin was an independent biologic prognostic factor.

Conclusion: In addition to stage, PS and, to a lesser extent, age and gender seem to be important prognostic factors for survival in lung cancer. Although this data was obtained from the largest series ever used for such an analysis in lung cancer, these prognostic factors and models require confirmation in the prospective study already planned by the International Association for the Study of Lung Cancer Lung Cancer Staging Project.

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• The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer.

  Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, Shaikh Z, Goldstraw P; International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions. Shepherd FA, et al. J Thorac Oncol. 2007 Dec;2(12):1067-77. doi: 10.1097/JTO.0b013e31815bdc0d. J Thorac Oncol. 2007. PMID: 18090577

• The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer.

  Chansky K, Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw P; International Staging Committee and Participating Institutions. Chansky K, et al. J Thorac Oncol. 2009 Jul;4(7):792-801. doi: 10.1097/JTO.0b013e3181a7716e. J Thorac Oncol. 2009. PMID: 19458556

• Non-small cell lung cancer staging: proposed revisions to the TNM system.

  Schneider BJ. Schneider BJ. Cancer Imaging. 2008 Sep 30;8(1):181-5. doi: 10.1102/1470-7330.2008.0029. Cancer Imaging. 2008. PMID: 18824424 Free PMC article. Review.

• Staging of non-small cell lung cancer (NSCLC): a review.

  Tsim S, O'Dowd CA, Milroy R, Davidson S. Tsim S, et al. Respir Med. 2010 Dec;104(12):1767-74. doi: 10.1016/j.rmed.2010.08.005. Epub 2010 Sep 15. Respir Med. 2010. PMID: 20833010 Review.

• A retrospective study of risk and prognostic factors in relation to lower respiratory tract infection in elderly lung cancer patients.

  Qiao D, Wang Z, Lu Y, Wen X, Li H, Zhao H. Qiao D, et al. Am J Cancer Res. 2014 Dec 15;5(1):423-32. eCollection 2015. Am J Cancer Res. 2014. PMID: 25628950 Free PMC article.

• Does Very Poor Performance Status Systematically Preclude Single Agent Anti-PD-1 Immunotherapy? A Multicenter Study of 35 Consecutive Patients.

  Gounant V, Duruisseaux M, Soussi G, Van Hulst S, Bylicki O, Cadranel J, Wislez M, Trédaniel J, Spano JP, Helissey C, Chouaid C, Molinier O, Dhalluin X, Doucet L, Hureaux J, Cazes A, Zalcman G. Gounant V, et al. Cancers (Basel). 2021 Mar 2;13(5):1040. doi: 10.3390/cancers13051040. Cancers (Basel). 2021. PMID: 33801285 Free PMC article.

• Brain metastasis burden and management in patients with small cell lung cancer in Canada: a retrospective, population-based cohort study.

  Gaebe K, Erickson AW, Chen S, Menjak IB, Lok BH, Sahgal A, Chan KKW, Das S. Gaebe K, et al. EClinicalMedicine. 2024 Oct 3;77:102871. doi: 10.1016/j.eclinm.2024.102871. eCollection 2024 Nov. EClinicalMedicine. 2024. PMID: 39416386 Free PMC article.

• Efficacy and Safety of Anlotinib in Advanced Non-Small Cell Lung Cancer: A Real-World Study.

  Zhang K, Ma X, Gao H, Wang H, Qin H, Yang S, Liu X. Zhang K, et al. Cancer Manag Res. 2020 May 13;12:3409-3417. doi: 10.2147/CMAR.S246000. eCollection 2020. Cancer Manag Res. 2020. PMID: 32494205 Free PMC article.

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