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Showing content from https://pubmed.ncbi.nlm.nih.gov/18162138/ below:

Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype

Affiliations

Affiliation

¹ Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA. hausauer@stanfordalumni.org

PMID: 18162138
PMCID: PMC2246193
DOI: 10.1186/bcr1839

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Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype

Amelia K Hausauer et al. Breast Cancer Res. 2007.

Affiliation

¹ Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA. hausauer@stanfordalumni.org

PMID: 18162138
PMCID: PMC2246193
DOI: 10.1186/bcr1839

Item in Clipboard

Abstract

Background: Recently, unprecedented drops in breast cancer incidence have been reported for populations of mostly White European descent. Incidence patterns in non-White racial/ethnic groups are less described. Therefore, we examined population-based breast cancer incidence trends separately for US Asian/Pacific Islander, Hispanic, African-American, and non-Hispanic White women by etiologically relevant tumor subtype characteristics, including hormone receptor status, histology, size, and in situ behavior.

Methods: We obtained breast cancer data from 13 Surveillance, Epidemiology, and End Results (SEER) cancer registries to calculate age-adjusted incidence rates and trends, stratified by race/ethnicity and tumor subtype for the period 1992-2004. Detailed analyses were limited to women 50 years old or older. Joinpoint regression was used to assess incidence trends by annual quarter of diagnosis.

Results: Between 2001 and 2004, incidence rates of invasive breast cancer in women 50 years old or older declined appreciably among Asians/Pacific Islanders (-8.5%) and Hispanics (-2.9%) and were stable in African-Americans (+0.5%), reductions substantially lower than those observed among non-Hispanic Whites (-14.3%). In Asian/Pacific Islander women, perceptible but statistically nonsignificant decreases were observed for hormone receptor-positive, lobular, and small tumors only. Rates of hormone receptor-negative tumors increased among African-Americans (26.1%) and Hispanics (26.9%) during 2001-2004. Incidence trends in most groups, except African-American women, peaked between 1999 and mid-2002. Rates of in situ cancer remained stable in all groups.

Conclusion: Recently reported reductions in breast cancer incidence varied considerably by race/ethnicity. These patterns are consistent with documented racial/ethnic differences in the prevalence and discontinuation of hormone therapy (HT) after July 2002 but do not correspond as well to patterns of mammography use in these groups. The data presented in this analysis provide further evidence that population-level HT use is a major influence on population-level rates of particular breast cancer subtypes, especially receptor-positive tumors.

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Figures
Figure 1

Breast cancer incidence among women…

Figure 1

Breast cancer incidence among women 50 years old or older by tumor behavior,…

Figure 1

Breast cancer incidence among women 50 years old or older by tumor behavior, race/ethnicity, and year according to Surveillance, Epidemiology, and End Results-13. (a) Trends for invasive breast cancer. (b) Trends for in situ breast cancer. All rates are age-adjusted to the 2000 US standard.

Figure 2

Invasive breast cancer incidence among…

Figure 2

Invasive breast cancer incidence among women 50 years old or older by receptor…

Figure 2

Invasive breast cancer incidence among women 50 years old or older by receptor status, race/ethnicity, and year according to Surveillance, Epidemiology, and End Results-13. (a) Trends for ER⁺/PR⁺breast cancer. (b) Trends for ER⁺/PR^-breast cancer. (c) Trends for ER^-/PR⁺breast cancer. (d) Trends for ER^-/PR^-breast cancer. (e) Trends for other/unknown breast cancer. All rates are age-adjusted to the 2000 US standard. ER, estrogen receptor; PR, progesterone receptor.

Figure 3

Invasive breast cancer incidence among…

Figure 3

Invasive breast cancer incidence among women 50 years old or older by tumor…

Figure 3

Invasive breast cancer incidence among women 50 years old or older by tumor histology, race/ethnicity, and year according to Surveillance, Epidemiology, and End Results-13. (a) Trends for ILC breast cancer. (b) Trends for IDC breast cancer. (c) Trends for IDLC breast cancer. (d) Trends for other/unknown breast cancer. All rates are age-adjusted to the 2000 US standard. IDC, invasive ductal carcinoma; IDLC, invasive ducto-lobular carcinoma; ILC, invasive lobular carcinoma.

Figure 4

Invasive breast cancer incidence among…

Figure 4

Invasive breast cancer incidence among women 50 years old or older by tumor…

Figure 4

Invasive breast cancer incidence among women 50 years old or older by tumor size, race/ethnicity, and year according to Surveillance, Epidemiology, and End Results-13. (a) Trends for tumors with diameter less than 2 cm. (b) Trends for tumors with diameter greater than or equal to 2 cm. (c) Trends for unknown tumors. All rates are age-adjusted to the 2000 US standard.