Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/17805057/ below:

Risk factors for recurrence and unfavorable prognosis in patients with stage I non-small cell lung cancer and a tumor diameter of 20 mm or less

Affiliations

• ¹ Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

• PMID: 17805057
• DOI: 10.1097/JTO.0b013e31814617c7

Item in Clipboard

Naruyuki Kobayashi et al. J Thorac Oncol. 2007 Sep.

• ¹ Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

• PMID: 17805057
• DOI: 10.1097/JTO.0b013e31814617c7

Item in Clipboard

Background: The purpose of this study was to identify risk factors for disease recurrence and unfavorable prognosis after surgical resection for stage I non-small cell lung cancer in patients with tumor diameters of < or =20 mm.

Methods: One hundred sixty-three patients who had pathologic stage I non-small cell lung cancer with tumor diameters < or =20 mm and who had undergone a lobectomy with mediastinal lymph node dissection were retrospectively reviewed. The relationships between clinicopathologic factors and clinical outcomes, including recurrence and survival, were then examined. The clinicopathologic factors examined in this study were age, sex, smoking status, preoperative serum carcinoembryonic antigen level, pathologic tumor size, histologic subtype, histologic grade, and visceral pleural invasion.

Results: Among the clinicopathologic factors that were examined, the histologic grade of the carcinoma status was significantly related to a high risk of recurrence when analyzed using univariate (p = 0.01) and multivariate analyses (p = 0.049). Regarding survival, patients with poorly differentiated carcinomas showed a significantly unfavorable overall survival (p < 0.001), disease-specific survival (p = 0.003), and disease-free survival (p = 0.002) compared with patients with well-/moderately differentiated carcinomas according to univariate analyses. A Cox proportional hazards model indicated that a poorly differentiated carcinoma status was the only independent factor for an unfavorable overall survival (p = 0.02), disease-specific survival (p = 0.046), and disease-free survival (p = 0.04).

Conclusions: Poor differentiation of tumor was the only risk factor for recurrence and an unfavorable prognosis for stage I non-small cell lung cancer patients with tumor diameters of < or =20 mm.

PubMed Disclaimer

• Prognostic factors in resected stage I non-small cell lung cancer with a diameter of 3 cm or less: visceral pleural invasion did not influence overall and disease-free survival.

  Hung JJ, Wang CY, Huang MH, Huang BS, Hsu WH, Wu YC. Hung JJ, et al. J Thorac Cardiovasc Surg. 2007 Sep;134(3):638-43. doi: 10.1016/j.jtcvs.2007.04.059. J Thorac Cardiovasc Surg. 2007. PMID: 17723811

• Risk factor analysis of locoregional recurrence after sublobar resection in patients with clinical stage IA non-small cell lung cancer.

  Koike T, Koike T, Yoshiya K, Tsuchida M, Toyabe S. Koike T, et al. J Thorac Cardiovasc Surg. 2013 Aug;146(2):372-8. doi: 10.1016/j.jtcvs.2013.02.057. J Thorac Cardiovasc Surg. 2013. PMID: 23870323

• Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer.

  Shimizu K, Yoshida J, Nagai K, Nishimura M, Ishii G, Morishita Y, Nishiwaki Y. Shimizu K, et al. J Thorac Cardiovasc Surg. 2005 Jul;130(1):160-5. doi: 10.1016/j.jtcvs.2004.11.021. J Thorac Cardiovasc Surg. 2005. PMID: 15999057

• [Prognostic indicators in stage I non-small cell lung cancer].

  Barlési F, Doddoli C, Greillier L, Astoul P, Giudicelli R, Fuentes P, Thomas P. Barlési F, et al. Rev Mal Respir. 2004 Feb;21(1):93-103. doi: 10.1016/s0761-8425(04)71239-5. Rev Mal Respir. 2004. PMID: 15260042 Review. French.

• [PROGNOSTIC FACTORS IN NON SMALL CELL LUNG CANCER].

  Gester F, Paulus A, Sibille AL, Duysinx B, Louis R. Gester F, et al. Rev Med Liege. 2016 Jan;71(1):34-9. Rev Med Liege. 2016. PMID: 26983312 Review. French.

• Prognostic significance of grading in lung adenocarcinoma.

  Barletta JA, Yeap BY, Chirieac LR. Barletta JA, et al. Cancer. 2010 Feb 1;116(3):659-69. doi: 10.1002/cncr.24831. Cancer. 2010. PMID: 20014400 Free PMC article.

• Prognostic Factors for Post Recurrence Survival in Resected Pathological Stage I Non-small Cell Lung Cancer.

  Kubouchi Y, Kidokoro Y, Ohno T, Yurugi Y, Wakahara M, Haruki T, Nakamura H. Kubouchi Y, et al. Yonago Acta Med. 2018 Feb 5;60(4):213-219. doi: 10.24563/yam.2017.12.001. eCollection 2017 Dec. Yonago Acta Med. 2018. PMID: 29434490 Free PMC article.

• Lung Cancer Staging and Associated Genetic and Epigenetic Events.

  Kim D, Lee YS, Kim DH, Bae SC. Kim D, et al. Mol Cells. 2020 Jan 31;43(1):1-9. doi: 10.14348/molcells.2020.2246. Mol Cells. 2020. PMID: 31999917 Free PMC article. Review.

• History, molecular features, and clinical importance of conventional serum biomarkers in lung cancer.

  Nakamura H, Nishimura T. Nakamura H, et al. Surg Today. 2017 Sep;47(9):1037-1059. doi: 10.1007/s00595-017-1477-y. Epub 2017 Feb 22. Surg Today. 2017. PMID: 28229299 Review.

• The effect of TTF-1 expression on ipsilateral mediastinal nodal (N2) metastases in primary adenocarcinoma of the lung.

  Samancilar O, Kaya SO, Ceylan KC, Usluer O, Yener AG. Samancilar O, et al. Contemp Oncol (Pozn). 2012;16(6):516-9. doi: 10.5114/wo.2012.32484. Epub 2013 Jan 4. Contemp Oncol (Pozn). 2012. PMID: 23788938 Free PMC article.

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3