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Showing content from https://pubmed.ncbi.nlm.nih.gov/16684987/ below:

Increasing incidence of thyroid cancer in the United States, 1973-2002

. 2006 May 10;295(18):2164-7. doi: 10.1001/jama.295.18.2164. Increasing incidence of thyroid cancer in the United States, 1973-2002

Affiliations

Affiliation

¹ VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, Vt 05009, USA. louise.davies@dartmouth.edu

PMID: 16684987
DOI: 10.1001/jama.295.18.2164

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Increasing incidence of thyroid cancer in the United States, 1973-2002

Louise Davies et al. JAMA. 2006.

. 2006 May 10;295(18):2164-7. doi: 10.1001/jama.295.18.2164. Affiliation

¹ VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, Vt 05009, USA. louise.davies@dartmouth.edu

PMID: 16684987
DOI: 10.1001/jama.295.18.2164

Item in Clipboard

Abstract

Context: Increasing cancer incidence is typically interpreted as an increase in the true occurrence of disease but may also reflect changing pathological criteria or increased diagnostic scrutiny. Changes in the diagnostic approach to thyroid nodules may have resulted in an increase in the apparent incidence of thyroid cancer.

Objective: To examine trends in thyroid cancer incidence, histology, size distribution, and mortality in the United States.

Methods: Retrospective cohort evaluation of patients with thyroid cancer, 1973-2002, using the Surveillance, Epidemiology, and End Results (SEER) program and data on thyroid cancer mortality from the National Vital Statistics System.

Main outcome measures: Thyroid cancer incidence, histology, size distribution, and mortality.

Results: The incidence of thyroid cancer increased from 3.6 per 100,000 in 1973 to 8.7 per 100,000 in 2002-a 2.4-fold increase (95% confidence interval [CI], 2.2-2.6; P<.001 for trend). There was no significant change in the incidence of the less common histological types: follicular, medullary, and anaplastic (P>.20 for trend). Virtually the entire increase is attributable to an increase in incidence of papillary thyroid cancer, which increased from 2.7 to 7.7 per 100,000-a 2.9-fold increase (95% CI, 2.6-3.2; P<.001 for trend). Between 1988 (the first year SEER collected data on tumor size) and 2002, 49% (95% CI, 47%-51%) of the increase consisted of cancers measuring 1 cm or smaller; 87% (95% CI, 85%-89%) consisted of cancers measuring 2 cm or smaller. Mortality from thyroid cancer was stable between 1973 and 2002 (approximately 0.5 deaths per 100,000).

Conclusions: The increasing incidence of thyroid cancer in the United States is predominantly due to the increased detection of small papillary cancers. These trends, combined with the known existence of a substantial reservoir of subclinical cancer and stable overall mortality, suggest that increasing incidence reflects increased detection of subclinical disease, not an increase in the true occurrence of thyroid cancer.

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Comment in

Managing small thyroid cancers.
Mazzaferri EL. Mazzaferri EL. JAMA. 2006 May 10;295(18):2179-82. doi: 10.1001/jama.295.18.2179. JAMA. 2006. PMID: 16684990 No abstract available.
Changing incidence of thyroid cancer.
Zhang Y, Zhu Y, Risch HA. Zhang Y, et al. JAMA. 2006 Sep 20;296(11):1350; author reply 1350. doi: 10.1001/jama.296.11.1350-a. JAMA. 2006. PMID: 16985224 No abstract available.