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Showing content from https://pubmed.ncbi.nlm.nih.gov/16551373/ below:

Remarkable change in age-specific breast cancer incidence in the Swiss canton of Geneva and its possible relation with the use of hormone replacement therapy

doi: 10.1186/1471-2407-6-78. Remarkable change in age-specific breast cancer incidence in the Swiss canton of Geneva and its possible relation with the use of hormone replacement therapy

Affiliations

Affiliation

¹ Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 boulevard de la Cluse, 1205 Geneva, Switzerland. christine.bouchardymagnin@imsp.unige.ch

PMID: 16551373
PMCID: PMC1440868
DOI: 10.1186/1471-2407-6-78

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Remarkable change in age-specific breast cancer incidence in the Swiss canton of Geneva and its possible relation with the use of hormone replacement therapy

Christine Bouchardy et al. BMC Cancer. 2006.

doi: 10.1186/1471-2407-6-78. Affiliation

¹ Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 boulevard de la Cluse, 1205 Geneva, Switzerland. christine.bouchardymagnin@imsp.unige.ch

PMID: 16551373
PMCID: PMC1440868
DOI: 10.1186/1471-2407-6-78

Item in Clipboard

Abstract

Background: This article aims to explain the reasons for the remarkable change in age of breast cancer occurrence in the Swiss canton of Geneva.

Methods: We used population-based data from the Geneva cancer registry, which collects information on method of detection, stage and tumour characteristics since 1975. For patients diagnosed between 1997-2003, we obtained additional information on use of hormone replacement therapy from a large prospective study on breast cancer. Using generalized log linear regression analysis, we compared age-specific incidence rates with respect to period, stage, oestrogen receptor status, method of detection and use of hormone replacement therapy.

Results: In the periods 1975-1979 and 1985-1989, breast cancer risk increased with age, showing the highest incidence rates among women aged >or= 85 years. From 1997, the age-specific incidence curve changed completely (p < 0.0001), showing an incidence peak at 60-64 years and a reduced incidence among elderly women. This incidence peak concerned mainly early stage and oestrogen positive cancers and was exclusively observed among women who ever used hormone replacement therapy, regardless whether the tumour was screen-detected or not.

Conclusion: The increasing prevalence of hormone replacement therapy use during the 1990s could explain the important change in age-specific breast cancer incidence, not only by increasing breast cancer risk, but also by revealing breast cancer at an earlier age.

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Figures
Figure 1

Invasive breast cancer incidence rates…

Figure 1

Invasive breast cancer incidence rates by age and period, Geneva cancer registry 1975–2003.

Figure 1

Invasive breast cancer incidence rates by age and period, Geneva cancer registry 1975–2003.

Figure 2

Invasive breast cancer incidence rates…

Figure 2

Invasive breast cancer incidence rates according to stage at diagnosis (panel a) and…

Figure 2

Invasive breast cancer incidence rates according to stage at diagnosis (panel a) and oestrogen receptor status (panel b) 1997–2000. Panel a. Panel b.

Figure 3

Invasive breast cancer incidence according…

Figure 3

Invasive breast cancer incidence according to ever use of hormone replacement therapy (HRT)…

Figure 3

Invasive breast cancer incidence according to ever use of hormone replacement therapy (HRT) and detection by mammography screening, 1997–2000. As information on HRT use was available for 46% of all breast cancer patients, breast cancer incidence rates are approximately half of the overall breast cancer incidence rates during the period 1997–2000.