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Accuracy of screening for fecal occult blood on a single stool sample obtained by digital rectal examination: a comparison with recommended sampling practice

Comparative Study

Affiliations

• ¹ Department of Veterans Affairs Medical Centers, Portland, Oregon 97239, USA.

• PMID: 15657155
• DOI: 10.7326/0003-4819-142-2-200501180-00006

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Comparative Study

Judith F Collins et al. Ann Intern Med. 2005.

• ¹ Department of Veterans Affairs Medical Centers, Portland, Oregon 97239, USA.

• PMID: 15657155
• DOI: 10.7326/0003-4819-142-2-200501180-00006

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Background: Many expert panels recommend colorectal cancer screening for average-risk asymptomatic individuals older than 50 years of age. Recent studies have found that 24% to 64% of primary care providers use only the digital fecal occult blood test (FOBT) as their primary screening test. The effectiveness of a single digital FOBT is unknown.

Objective: To compare the sensitivity and specificity of digital FOBT and the recommended 6-sample at-home FOBT for advanced neoplasia in asymptomatic persons.

Design: Prospective cohort study.

Setting: 13 Veterans Affairs medical centers.

Patients: 3121 asymptomatic patients 50 to 75 years of age.

Intervention: 2665 patients had 6-sample at-home FOBT and digital FOBT, followed by complete colonoscopy.

Measurements: We measured the sensitivity of digital and 6-sample FOBT for advanced neoplasia and the specificity for no neoplasia. We calculated predictive values and likelihood ratios for advanced neoplasia, defined as tubular adenomas 10 mm or greater, adenomas with villous histology or high-grade dysplasia, or invasive cancer.

Results: Of all participants, 96.8% were men; their average age was 63.1 years. The 6-sample FOBT and the single digital FOBT had specificities of 93.9% and 97.5%, respectively, as defined by studying 1656 patients with no neoplasia. Sensitivities for detection of advanced neoplasia in 284 patients were 23.9% for the 6-sample FOBT and 4.9% for the digital FOBT. The likelihood ratio for advanced neoplasia was 1.68 (95% CI, 0.96 to 2.94) for positive results on digital FOBT and 0.98 (CI, 0.95 to 1.01) for negative results.

Limitations: Most patients were men.

Conclusions: Single digital FOBT is a poor screening method for colorectal neoplasia and cannot be recommended as the only test. When digital FOBT is performed as part of a primary care physical examination, negative results do not decrease the odds of advanced neoplasia. Persons with these results should be offered at-home 6-sample FOBT or another type of screening test.

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• Summaries for patients. What is the best way to test for colorectal cancer?

  [No authors listed] [No authors listed] Ann Intern Med. 2005 Jan 18;142(2):I23. doi: 10.7326/0003-4819-142-2-200501180-00001. Ann Intern Med. 2005. PMID: 15657150 No abstract available.

• One-time screening for colorectal cancer with combined fecal occult-blood testing and examination of the distal colon.

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