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Showing content from https://pubmed.ncbi.nlm.nih.gov/14647295/ below:

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

Review

Affiliations

• ¹ Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. dwolf@hsph.harvard.edu

• PMID: 14647295
• DOI: 10.1038/ncb1203-1029

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Review

Dieter A Wolf et al. Nat Cell Biol. 2003 Dec.

• ¹ Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. dwolf@hsph.harvard.edu

• PMID: 14647295
• DOI: 10.1038/ncb1203-1029

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The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

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• The COP9 signalosome.

  Wei N, Deng XW. Wei N, et al. Annu Rev Cell Dev Biol. 2003;19:261-86. doi: 10.1146/annurev.cellbio.19.111301.112449. Annu Rev Cell Dev Biol. 2003. PMID: 14570571 Review.

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