Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/10209974/ below:

Influence of delay on survival in patients with breast cancer: a systematic review

Review

Affiliations

• ¹ ICRF Psychosocial Oncology Group, Guy's, King's and St Thomas's School of Medicine, St Thomas' Hospital, London, UK.

• PMID: 10209974
• DOI: 10.1016/s0140-6736(99)02143-1

Item in Clipboard

Review

M A Richards et al. Lancet. 1999.

• ¹ ICRF Psychosocial Oncology Group, Guy's, King's and St Thomas's School of Medicine, St Thomas' Hospital, London, UK.

• PMID: 10209974
• DOI: 10.1016/s0140-6736(99)02143-1

Item in Clipboard

Background: Most patients with breast cancer are detected after symptoms occur rather than through screening. The impact on survival of delays between the onset of symptoms and the start of treatment is controversial and cannot be studied in randomised controlled trials. We did a systematic review of observational studies (worldwide) of duration of symptoms and survival.

Methods: We identified 87 studies (101,954 patients) with direct data linking delay (including delay by patients) and survival. We classified studies for analysis by type of data in the original reports: category I studies had actual 5-year survival data (38 studies, 53,912 patients); category II used actuarial or multivariate analyses (21 studies, 25,102 patients); and category III was all other types of data (28 studies, 22,940 patients). We tested the main hypothesis that longer delays would be associated with lower survival, and a secondary hypothesis that longer delays were associated with more advanced stage, which would account for lower survival.

Findings: In category I studies, patients with delays of 3 months or more had 12% lower 5-year survival than those with shorter delays (odds ratio for death 1.47 [95% CI 1.42-1.53]) and those with delays of 3-6 months had 7% lower survival than those with shorter delays (1.24 [1.17-1.30]). In category II, 13 of 14 studies with unrestricted samples showed a significant adverse relation between longer delays and survival, whereas four of five studies of only patients with operable disease showed no significant relation. In category III, all three studies with unrestricted samples supported the primary hypothesis. The 13 informative studies showed that longer delays were associated with more advanced stage. In studies that controlled for stage, longer delay was not associated with shorter survival when the effect of stage on survival was taken into account.

Interpretation: Delays of 3-6 months are associated with lower survival. These effects cannot be accounted for by lead-time bias. Efforts should be made to keep delays by patients and providers to a minimum.

PubMed Disclaimer

• Breast cancer: delays, dilemmas, and delusions.

  Coates AS. Coates AS. Lancet. 1999 Apr 3;353(9159):1112-3. doi: 10.1016/S0140-6736(99)00082-3. Lancet. 1999. PMID: 10209969 No abstract available.

• Delay in diagnosis in breast cancer.

  Benson EA. Benson EA. Lancet. 1999 Jun 19;353(9170):2154; author reply 2155. doi: 10.1016/s0140-6736(99)99108-0. Lancet. 1999. PMID: 10382714 No abstract available.

• Delay in diagnosis in breast cancer.

  Nosarti C, Crayford T, Roberts J, McKenzie K, David A. Nosarti C, et al. Lancet. 1999 Jun 19;353(9170):2154; author reply 2155. doi: 10.1016/S0140-6736(05)75586-0. Lancet. 1999. PMID: 10382715 No abstract available.

• Delay in diagnosis in breast cancer.

  Bentzen SM, Dische S, Bond S. Bentzen SM, et al. Lancet. 1999 Jun 19;353(9170):2155-6. doi: 10.1016/S0140-6736(05)75589-6. Lancet. 1999. PMID: 10382717 No abstract available.

• Delays in diagnosis in breast cancer.

  Crawford SM. Crawford SM. Lancet. 1999 Oct 23;354(9188):1478. doi: 10.1016/s0140-6736(05)77623-6. Lancet. 1999. PMID: 10543704 No abstract available.

• The influence on survival of delay in the presentation and treatment of symptomatic breast cancer.

  Richards MA, Smith P, Ramirez AJ, Fentiman IS, Rubens RD. Richards MA, et al. Br J Cancer. 1999 Feb;79(5-6):858-64. doi: 10.1038/sj.bjc.6690137. Br J Cancer. 1999. PMID: 10070881 Free PMC article.

• 22. Diagnostic delays in breast cancer and impact on survival.

  Kothari A, Fentiman IS. Kothari A, et al. Int J Clin Pract. 2003 Apr;57(3):200-3. Int J Clin Pract. 2003. PMID: 12723724 Review.

• Factors predicting delayed presentation of symptomatic breast cancer: a systematic review.

  Ramirez AJ, Westcombe AM, Burgess CC, Sutton S, Littlejohns P, Richards MA. Ramirez AJ, et al. Lancet. 1999 Apr 3;353(9159):1127-31. doi: 10.1016/s0140-6736(99)02142-x. Lancet. 1999. PMID: 10209975 Review.

• [Determinants of patient and health system delays for women with breast cancer in Morocco, 2013].

  Benbakhta B, Tazi M, Benjaafar N, Khattabi A, Maaroufi A. Benbakhta B, et al. Rev Epidemiol Sante Publique. 2015 Jun;63(3):191-201. doi: 10.1016/j.respe.2015.03.121. Epub 2015 May 11. Rev Epidemiol Sante Publique. 2015. PMID: 25975777 French.

• Effect on survival of delays in referral of patients with breast-cancer symptoms: a retrospective analysis.

  Sainsbury R, Johnston C, Haward B. Sainsbury R, et al. Lancet. 1999 Apr 3;353(9159):1132-5. doi: 10.1016/s0140-6736(99)02374-0. Lancet. 1999. PMID: 10209976

• Perioperative Management of Robotic-Assisted Gynecological Surgery in a Super Morbidly Obese Patient.

  Noguchi S, Takahata O, Tsukada A, Shimada M, Kikuchi N. Noguchi S, et al. Cureus. 2022 Sep 28;14(9):e29674. doi: 10.7759/cureus.29674. eCollection 2022 Sep. Cureus. 2022. PMID: 36321014 Free PMC article.

• Development and feasibility of a set of quality indicators relative to the timeliness and organisation of care for new breast cancer patients undergoing surgery.

  Ferrua M, Couralet M, Nitenberg G, Morin S, Serin D, Minvielle E. Ferrua M, et al. BMC Health Serv Res. 2012 Jun 21;12:167. doi: 10.1186/1472-6963-12-167. BMC Health Serv Res. 2012. PMID: 22721001 Free PMC article.

• Optimizing cancer care through mobile health.

  Odeh B, Kayyali R, Nabhani-Gebara S, Philip N. Odeh B, et al. Support Care Cancer. 2015 Jul;23(7):2183-8. doi: 10.1007/s00520-015-2627-7. Epub 2015 Feb 4. Support Care Cancer. 2015. PMID: 25649121 Review.

• Diagnostic intervals and its association with breast, prostate, lung and colorectal cancer survival in England: historical cohort study using the Clinical Practice Research Datalink.

  Redaniel MT, Martin RM, Ridd MJ, Wade J, Jeffreys M. Redaniel MT, et al. PLoS One. 2015 May 1;10(5):e0126608. doi: 10.1371/journal.pone.0126608. eCollection 2015. PLoS One. 2015. PMID: 25933397 Free PMC article.

• Primary Care Physicians' Perceived Barriers to Follow-Up of Abnormal Mammogram Results: Opportunities for Systems-Level Interventions.

  Flynn SJ, Livaudais-Toman J, Kaplan CP, Kerlikowske K, Burke NJ, Pathak S, Karliner LS. Flynn SJ, et al. J Gen Intern Med. 2023 May;38(7):1786-1788. doi: 10.1007/s11606-022-07967-7. Epub 2022 Nov 30. J Gen Intern Med. 2023. PMID: 36451017 Free PMC article. No abstract available.

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3