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Showing content from https://patents.google.com/patent/UY32561A/en below:

UY32561A - DERIVATIVES OF N - [(7-AZA-BICICLO [2.2.1] HEPT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.

Publication number

UY32561A

UY32561A UY0001032561A UY32561A UY32561A UY 32561 A UY32561 A UY 32561A UY 0001032561 A UY0001032561 A UY 0001032561A UY 32561 A UY32561 A UY 32561A UY 32561 A UY32561 A UY 32561A

Authority

UY

Uruguay

Prior art keywords

alkyl

groups

alkoxy

cycloalkyl

halo

Prior art date

2009-04-14

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 title 1
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
• 125000005843 halogen group Chemical group 0.000 abstract 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
• 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
• 125000001424 substituent group Chemical group 0.000 abstract 2
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
• 239000002253 acid Substances 0.000 abstract 1
• 125000003342 alkenyl group Chemical group 0.000 abstract 1
• 125000003545 alkoxy group Chemical group 0.000 abstract 1
• 150000001875 compounds Chemical class 0.000 abstract 1
• 229910052731 fluorine Inorganic materials 0.000 abstract 1
• 125000001153 fluoro group Chemical group F* 0.000 abstract 1
• -1 halo (C1-C6) alkyl Chemical group 0.000 abstract 1
• 150000003839 salts Chemical class 0.000 abstract 1
• 230000001225 therapeutic effect Effects 0.000 abstract 1

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
  • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
  • C07D487/08—Bridged systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/04—Centrally acting analgesics, e.g. opioids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/06—Antimigraine agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/20—Hypnotics; Sedatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/22—Anxiolytics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/24—Antidepressants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
  • A61P25/32—Alcohol-abuse
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
  • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
  • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D207/14—Nitrogen atoms not forming part of a nitro radical

• Health & Medical Sciences (AREA)
• Organic Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Engineering & Computer Science (AREA)
• Veterinary Medicine (AREA)
• General Health & Medical Sciences (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• General Chemical & Material Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Medicinal Chemistry (AREA)
• Public Health (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Neurosurgery (AREA)
• Biomedical Technology (AREA)
• Neurology (AREA)
• Psychiatry (AREA)
• Pain & Pain Management (AREA)
• Addiction (AREA)
• Rheumatology (AREA)
• Psychology (AREA)
• Anesthesiology (AREA)
• Hospice & Palliative Care (AREA)
• Nutrition Science (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Nitrogen Condensed Heterocyclic Rings (AREA)

Compuestos de fórmula (I): en la que:- R representa un átomo de hidrógeno o un grupo elegido entre los grupos alquilo(C1-C6), cicloalquilo (C3-C7), opcionalmente sustituido con uno o varios grupos elegidos independientemente entre sí entre el átomo de flúor, los grupos cicloalquilo(C3-C7), alquenilo(C2-C4), fenilo, alcoxi(C1.C6), hidroxi; el grupo fenilo está opcionalmente sustituido con uno o varios grupos alcoxi(C1-C6);-R1 representa un grupo fenilo opcionalmente sustituido con uno o varios sustituyentes elegidos independientemente entre sí entre los átomos de halógeno, los grupos alquilo(C1-C6), alcoxi(C1-C6), halo-alquilo(C1-C6), hidroxi, halo.alcoxi(C1-C6)-SO2,-R2 representa uno o varios sustituyentes elegidos entre el átomo de hidrógeno, los átomos de halógeno, los grupos halo-alquilo(C1-C6), alquilo(C1-C6), cicloalquilo(C3-C7), cicloalqui(C3-C7)-alquilo(C1-C3), alcoxi(C1-C6), alquil(C1-C6)-tio, alquil(C1-C6)-SO2; en forma de base o de sal de adición a un ácido. Utilización en terapéutica y procedimiento de síntesis.Compounds of formula (I): in which: - R represents a hydrogen atom or a group selected from the (C1-C6) alkyl, cycloalkyl (C3-C7) groups, optionally substituted with one or more groups independently selected from each other among the fluorine atom, the cycloalkyl (C3-C7), alkenyl (C2-C4), phenyl, alkoxy (C1.C6), hydroxy groups; the phenyl group is optionally substituted with one or more (C1-C6) alkoxy groups; - R1 represents a phenyl group optionally substituted with one or more substituents independently selected from each other among the halogen atoms, the (C1-C6) alkyl groups, (C1-C6) alkoxy, halo (C1-C6) alkyl, hydroxy, halo.C1-C6 alkoxy -SO2, -R2 represents one or more substituents chosen from the hydrogen atom, the halogen atoms, the groups halo (C1-C6) alkyl, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkyl (C1-C3) alkyl, (C1-C6) alkoxy, (C1-C6) alkyl -thio, (C1-C6) alkyl -SO2; as a base or an acid addition salt. Use in therapeutic and synthetic procedure.

• 2009
  • 2009-04-14 FR FR0901809A patent/FR2944284A1/en not_active Withdrawn
• 2010
  • 2010-04-12 AR ARP100101220A patent/AR076276A1/en unknown
  • 2010-04-13 CA CA2758367A patent/CA2758367A1/en not_active Abandoned
  • 2010-04-13 SG SG2011075017A patent/SG175222A1/en unknown
  • 2010-04-13 WO PCT/FR2010/050711 patent/WO2010119222A1/en active Application Filing
  • 2010-04-13 EP EP10723665A patent/EP2419431A1/en not_active Withdrawn
  • 2010-04-13 AU AU2010238409A patent/AU2010238409A1/en not_active Abandoned
  • 2010-04-13 TW TW099111503A patent/TW201041581A/en unknown
  • 2010-04-13 BR BRPI1015484A patent/BRPI1015484A2/en not_active Application Discontinuation
  • 2010-04-13 JP JP2012505205A patent/JP2012523448A/en not_active Withdrawn
  • 2010-04-13 MX MX2011010929A patent/MX2011010929A/en not_active Application Discontinuation
  • 2010-04-13 KR KR1020117026894A patent/KR20120013378A/en not_active Withdrawn
  • 2010-04-14 UY UY0001032561A patent/UY32561A/en not_active Application Discontinuation
• 2011
  • 2011-10-10 IL IL215673A patent/IL215673A0/en unknown

Effective date: 20150601

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