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Showing content from https://patents.google.com/patent/GB1336732A/en below:

GB1336732A - Diethanolamine derivatives - Google Patents

GB1336732A - Diethanolamine derivatives - Google PatentsDiethanolamine derivatives Info

Publication number: GB1336732A
Authority: GB; United Kingdom
Prior art keywords: compounds; diethanolamines; morpholines; salts; alkyl
Prior art date: 1970-10-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB5122870A

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Istituto Gentili SpA

Original Assignee

Istituto Gentili SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-10-28

Filing date

1970-10-28

Publication date

1973-11-07

1970-10-28 Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA

1970-10-28 Priority to GB5122870A priority Critical patent/GB1336732A/en

1971-09-30 Priority to AU34072/71A priority patent/AU3407271A/en

1971-10-21 Priority to AR23859171A priority patent/AR192325A1/en

1971-10-22 Priority to DE19712152686 priority patent/DE2152686A1/en

1971-10-22 Priority to NL7114581A priority patent/NL7114581A/xx

1971-10-27 Priority to FR7138592A priority patent/FR2111882A1/fr

1971-10-27 Priority to CA126216A priority patent/CA934373A/en

1971-10-28 Priority to BE774629A priority patent/BE774629A/en

1973-11-07 Publication of GB1336732A publication Critical patent/GB1336732A/en

Status Expired legal-status Critical Current

Links

ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002780 morpholines Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
SZIFAVKTNFCBPC-UHFFFAOYSA-N 2-chloroethanol Chemical compound OCCCl SZIFAVKTNFCBPC-UHFFFAOYSA-N 0.000 abstract 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
AWMVMTVKBNGEAK-UHFFFAOYSA-N Styrene oxide Chemical compound C1OC1C1=CC=CC=C1 AWMVMTVKBNGEAK-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000003179 convulsant agent Substances 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
229940030606 diuretics Drugs 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1336732 Diethanolamines; morpholines ISTITUTO GENTILI SpA-PISA 28 Oct 1970 51228/70 Heading C2C Compounds of the general formula (Ar=Ph optionally substituted by one or more alkoxy groups; R 1-3 =H, alkyl; provided that at least one of R 1-3 =H, R 2 and R 3 =H when R 1 = alkyl, and when R 2 and R 3 = H the ring is substituted) and salts thereof are prepared by reacting the appropriate styrene oxide and aminoethanol, or arylethanolamine and ethylene chlorohydrin or ethylene oxide. These compounds may be ring-closed to the corresponding morpholines and salts thereof. Some of the above compounds are convulsants, and some of the diethanolamines are diuretics. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

GB5122870A 1970-10-28 1970-10-28 Diethanolamine derivatives Expired GB1336732A (en) Priority Applications (8) Application Number Priority Date Filing Date Title GB5122870A GB1336732A (en) 1970-10-28 1970-10-28 Diethanolamine derivatives AU34072/71A AU3407271A (en) 1970-10-28 1971-09-30 New diethanolamine and morpholine derivatives AR23859171A AR192325A1 (en) 1970-10-28 1971-10-21 A PROCEDURE FOR THE PREPARATION OF COMPOUNDS DERIVED FROM SUBSTITUTED MORPHOLINS DE19712152686 DE2152686A1 (en) 1970-10-28 1971-10-22 New derivatives of diaethanolamine and morpholine and processes for their preparation NL7114581A NL7114581A (en) 1970-10-28 1971-10-22 FR7138592A FR2111882A1 (en) 1970-10-28 1971-10-27 CA126216A CA934373A (en) 1970-10-28 1971-10-27 Diethanolamine and morpholine derivatives BE774629A BE774629A (en) 1970-10-28 1971-10-28 DIETHANOLAMINE AND MORPHOLINE DERIVATIVES AND THEIR PREPARATION Applications Claiming Priority (1) Application Number Priority Date Filing Date Title GB5122870A GB1336732A (en) 1970-10-28 1970-10-28 Diethanolamine derivatives Publications (1) Publication Number Publication Date GB1336732A true GB1336732A (en) 1973-11-07 Family ID=10459148 Family Applications (1) Application Number Title Priority Date Filing Date GB5122870A Expired GB1336732A (en) 1970-10-28 1970-10-28 Diethanolamine derivatives Country Status (8) Cited By (6) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title EP0027695A1 (en) * 1979-10-20 1981-04-29 JOHN WYETH & BROTHER LIMITED Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation WO1992018489A1 (en) * 1991-04-23 1992-10-29 The Wellcome Foundation Limited Arylmorpholine, preparation and use WO2006079809A1 (en) * 2005-01-25 2006-08-03 Norgine Europe Bv Compounds for treating urinary incontinence US8906908B2 (en) 2010-05-21 2014-12-09 Research Triangle Institute Hydroxybupropion analogues for treating drug dependence US9562001B2 (en) 2009-04-15 2017-02-07 Research Triangle Institute Monoamine reuptake inhibitors US9617229B2 (en) 2010-05-21 2017-04-11 Research Triangle Institute Phenylmorpholines and analogues thereof Families Citing this family (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title FR2471378A1 (en) * 1979-12-14 1981-06-19 Lafon Labor Alkylated 2:phenyl morpholine derivs. - having antidepressant and cardiovascular activity, prepd. by cyclising hydroxyalkyl phenyl ethanol(s)

1970
- 1970-10-28 GB GB5122870A patent/GB1336732A/en not_active Expired
1971
- 1971-09-30 AU AU34072/71A patent/AU3407271A/en not_active Expired
- 1971-10-21 AR AR23859171A patent/AR192325A1/en active
- 1971-10-22 NL NL7114581A patent/NL7114581A/xx unknown
- 1971-10-22 DE DE19712152686 patent/DE2152686A1/en active Pending
- 1971-10-27 FR FR7138592A patent/FR2111882A1/fr not_active Withdrawn
- 1971-10-27 CA CA126216A patent/CA934373A/en not_active Expired
- 1971-10-28 BE BE774629A patent/BE774629A/en unknown

Cited By (10) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title EP0027695A1 (en) * 1979-10-20 1981-04-29 JOHN WYETH & BROTHER LIMITED Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation WO1992018489A1 (en) * 1991-04-23 1992-10-29 The Wellcome Foundation Limited Arylmorpholine, preparation and use US5648347A (en) * 1991-04-23 1997-07-15 Glaxo Wellcome Inc. Arylmorpholine, preparation and use WO2006079809A1 (en) * 2005-01-25 2006-08-03 Norgine Europe Bv Compounds for treating urinary incontinence JP2008528474A (en) * 2005-01-25 2008-07-31 ãã¼ã¸ã³ ã¨ã¼ããã ãã¼ãã¤ Compounds for the treatment of urinary incontinence US9562001B2 (en) 2009-04-15 2017-02-07 Research Triangle Institute Monoamine reuptake inhibitors US10919841B2 (en) 2009-04-15 2021-02-16 Research Triangle Institute Monoamine reuptake inhibitors US8906908B2 (en) 2010-05-21 2014-12-09 Research Triangle Institute Hydroxybupropion analogues for treating drug dependence US9527823B2 (en) 2010-05-21 2016-12-27 Research Triangle Institute Hydroxybupropion analogues for treating drug dependence US9617229B2 (en) 2010-05-21 2017-04-11 Research Triangle Institute Phenylmorpholines and analogues thereof Also Published As Similar Documents Legal Events Date Code Title Description 1973-09-26 416 Proceeding under section 16 patents act 1949 1974-03-20 PS Patent sealed 1975-05-29 PLNP Patent lapsed through nonpayment of renewal fees

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