Showing content from https://patents.google.com/patent/FR2285887A1/en below:
FR2285887A1 - 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc.
FR2285887A1 - 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. - Google Patents2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. Info
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Publication number
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FR2285887A1
FR2285887A1 FR7432773A FR7432773A FR2285887A1 FR 2285887 A1 FR2285887 A1 FR 2285887A1 FR 7432773 A FR7432773 A FR 7432773A FR 7432773 A FR7432773 A FR 7432773A FR 2285887 A1 FR2285887 A1 FR 2285887A1
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Authority
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FR
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France
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Prior art keywords
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active
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oxazines
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analgesics
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nervous system
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central nervous
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Prior art date
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1974-09-27
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Granted
Application number
FR7432773A
Other languages
French (fr)
Other versions
FR2285887B1 (en
Inventor
Roland Yves Mauvernay
Norbert Busch
Jacques Moleyre
Jacques Simond
Andre Monteil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-09-27
Filing date
1974-09-27
Publication date
1976-04-23
1974-09-27 Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
1974-09-27 Priority to FR7432773A priority Critical patent/FR2285887A1/en
1976-04-23 Publication of FR2285887A1 publication Critical patent/FR2285887A1/en
1978-07-21 Application granted granted Critical
1978-07-21 Publication of FR2285887B1 publication Critical patent/FR2285887B1/fr
Status Granted legal-status Critical Current
Links
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- -1 phenyl tetrahydro-1,4-oxazines Chemical class 0.000 title 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 230000003555 analeptic effect Effects 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 150000004893 oxazines Chemical class 0.000 abstract 1
- 239000003091 serenic agent Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oxazines of formula (I) (where R = H or alkyl; X1 = halogen or CF3, in the m or p position) are active on the central nervous system, esp. as analgesics, anti-aggressive agents and agents active against morphine withdrawal symptoms. Some of the compounds (I) are also anticonvulsants and no analeptics.
FR7432773A 1974-09-27 1974-09-27 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. Granted FR2285887A1 (en) Priority Applications (1) Application Number Priority Date Filing Date Title FR7432773A FR2285887A1 (en) 1974-09-27 1974-09-27 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. Applications Claiming Priority (1) Application Number Priority Date Filing Date Title FR7432773A FR2285887A1 (en) 1974-09-27 1974-09-27 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. Publications (2) Family ID=9143539 Family Applications (1) Application Number Title Priority Date Filing Date FR7432773A Granted FR2285887A1 (en) 1974-09-27 1974-09-27 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. Country Status (1) Cited By (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title EP0435387A1 (en) * 1989-12-29 1991-07-03 Shell Internationale Researchmaatschappij B.V. Piperidine derivatives Citations (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title BE728861A (en) * 1968-03-04 1969-08-01
Patent Citations (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title BE728861A (en) * 1968-03-04 1969-08-01 Cited By (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title EP0435387A1 (en) * 1989-12-29 1991-07-03 Shell Internationale Researchmaatschappij B.V. Piperidine derivatives Also Published As Similar Documents Publication Publication Date Title NL184801C (en) 1989-11-01 Displacer for compressible media. NL181170B (en) 1987-02-02 FLUID DELIVERY FOR DENTAL USE. DK139814B (en) 1979-04-23 Analogous process for the preparation of locally anesthetically active 2-alkyl-2- (dialkylamino- or pyrrolidino) -2 ', 6'-acetoxylidides in optically active or racemic form or pharmaceutically acceptable salts thereof. NL7705121A (en) 1977-11-15 CONCRETE BLOCK, PARTICULARLY INTENDED FOR LANE LIMITATION OR THE LIKE. NL7709508A (en) 1978-03-03 METHODS FOR THE PREPARATION OF AMINO ALKYLIDES-AMINO-1,4-DIHYDROPYRIDINS, AND THE USE OF THESE COMPOUNDS AS A MEDICINAL PRODUCT. NL7700702A (en) 1977-07-26 1,2-BENZISOTHIAZOLINONES-3, METHOD FOR PREPARING IT AND ITS USE AS A MEDICINAL PRODUCT. NL7709180A (en) 1978-02-22 CLEANER FOR PERSONAL HYGIENE. NL7610493A (en) 1977-05-02 SCREW LOCK FOR THERMOS JUGS. NL7506397A (en) 1975-12-02 COMBINED LAKE SYSTEM FOR DEEP WATERS. DK136213B (en) 1977-09-05 Process for the preparation of d, d'-2,2 '- (ethylenediimino) -di-1-butanol dihydrochloride. FR2285886A2 (en) 1976-04-23 2-(3-or 4-substd.)phenyl-tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. FR2285887A1 (en) 1976-04-23 2-(3-Trifluoro methyl)phenyl tetrahydro-1,4-oxazines - active on central nervous system as analgesics, anti-aggression agents etc. NL7511683A (en) 1976-05-24 NITRILE POLYMER AND PROCESS FOR PREPARING IT. NL7708105A (en) 1978-01-24 LIQUID PUMP, ESPECIALLY FOR PLASTER PLASTERS. NL7505801A (en) 1975-11-18 DIALYST COIL FOR USE IN PLASTIC KIDNEY MACHINES. NL183141B (en) 1988-03-01 PROCESS FOR PREPARING OPTICALLY ACTIVE CYCLIC N-SUBSTITUTED 1,3,2-OXAZAFOS FORERIVATIVES. NL173265C (en) 1984-01-02 PROCESS FOR PREPARING INTERMEDIATES FOR THE FORMATION OF 4,4'-DICYAN POLYHALOGEN-DIPHENOXYALKANS AND CONVERTING THESE INTERMEDIATES IN THESE DICYAN COMPOUNDS. DK140533B (en) 1979-09-24 Analogous process for the preparation of 4-hydroxy-2H-naphtho- (2,1-e) -1,2-thiazine-3-carboxamide-1,1-dioxides as well as salts thereof. NL7606345A (en) 1976-12-14 STORAGE AND PACKING CASSETTE FOR DIFFERENT TYPES OF CARDS, SHEETS AND THE LIKE. NL7509706A (en) 1976-02-17 3-METHYLPYRAZOL-5-CARBOXYLATES, METHOD FOR PREPARING THEM, AND THESE COMPOUNDS CONTAIN THE MEDICINAL PRODUCT PREPARATIONS. NL7708000A (en) 1978-01-25 PROCESS FOR THE PREPARATION OF NEW BENZAMIDINE AND N-SUBSTITUATED BENZAMIDINE COMPOUNDS. DK136829B (en) 1977-11-28 Analogous process for the preparation of 17beta-C1-8-alkoxy-3'H-cyclopropa (16alpha, 17alpha) 5alpha-androstano (2,3-d) isoxazoles. NL7608971A (en) 1977-03-29 PROCESS FOR PREPARING NEW 1-BENZOYL-2- (2 ', 6'-DICHLOROPHENYLAMINO) -2-IMIDAZOLINE AND ITS SALTS. DD128029A1 (en) 1977-10-26 DEVICE FOR CONTROLLING THE LEVEL OF TOOTHPASTOES MEDIA, ESPECIALLY LUBRICANTS, IN THE STORAGE OF FOERDER PUMPS JPS51134823A (en) 1976-11-22 Synchronous dynamotor Legal Events Date Code Title Description 1989-07-21 ST Notification of lapse
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