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Showing content from https://patents.google.com/patent/FR2168139A1/en below:

FR2168139A1 - N-acyl morpholines - with hypocholesterolaemic and anorectic activity

FR2168139A1 - N-acyl morpholines - with hypocholesterolaemic and anorectic activity - Google PatentsN-acyl morpholines - with hypocholesterolaemic and anorectic activity Info

Publication number: FR2168139A1
Authority: FR; France
Prior art keywords: opt; phenyl; substd; alk; halo
Prior art date: 1972-01-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

FR7201441A

Other languages

French (fr)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dynachim SARL

Original Assignee

Dynachim SARL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-01-17

Filing date

1972-01-17

Publication date

1973-08-31

1972-01-17 Application filed by Dynachim SARL filed Critical Dynachim SARL

1972-01-17 Priority to FR7201441A priority Critical patent/FR2168139A1/en

1973-08-31 Publication of FR2168139A1 publication Critical patent/FR2168139A1/en

Status Withdrawn legal-status Critical Current

Links

230000001539 anorectic effect Effects 0.000 title abstract 2
230000000871 hypocholesterolemic effect Effects 0.000 title abstract 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
SMGBVBYHJHBRDM-UHFFFAOYSA-N (3-methyl-2-phenylmorpholin-4-yl)-pyridin-3-ylmethanone Chemical compound CC1N(CCOC1C1=CC=CC=C1)C(C1=CN=CC=C1)=O SMGBVBYHJHBRDM-UHFFFAOYSA-N 0.000 abstract 1
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Title cpds. are of formula: (R1 = H, lower alkyl; R2 = phenyl opt. substd. by CH3, CH3O or Cl); R3 = 3-pyridyl or its N-oxide; 5-thiazolyl or B.Ph.O.A-(A = 1-18C opt. branched, opt. ethylenically unsatd. hydrocarbylene opt. carrying oxoor HO, or phenyl opt. substd. by alkyl, aralkyl, aryl, acyl, alkoxy or halo; B is 0-3 same or diff. alk(en)yl, CF3, cycloalk(en)yl, aryl, aralk(en)yl, halo, alkoxy, alkylthio, aryloxy, aralkoxy, arylthio or aralkylthio; B may also complete a naphthalene ring opt. with 1 or 2 of the above substnts. and when one of these is cyclohex(en)yl this may itself carry OH or oxo and/or alk(en)yl. (I), which hypocholesterolaemics and anorectics, are prepd. by reacting an N-unsubstd. morpholine with acid chloride or anhydride of R3CO2H in presence of base. A pref. (I) is 4-nicotinoyl-2-phenyl-3-methylmorpholine.

FR7201441A 1972-01-17 1972-01-17 N-acyl morpholines - with hypocholesterolaemic and anorectic activity Withdrawn FR2168139A1 (en) Priority Applications (1) Application Number Priority Date Filing Date Title FR7201441A FR2168139A1 (en) 1972-01-17 1972-01-17 N-acyl morpholines - with hypocholesterolaemic and anorectic activity Applications Claiming Priority (1) Application Number Priority Date Filing Date Title FR7201441A FR2168139A1 (en) 1972-01-17 1972-01-17 N-acyl morpholines - with hypocholesterolaemic and anorectic activity Publications (1) Publication Number Publication Date FR2168139A1 true FR2168139A1 (en) 1973-08-31 Family ID=9092004 Family Applications (1) Application Number Title Priority Date Filing Date FR7201441A Withdrawn FR2168139A1 (en) 1972-01-17 1972-01-17 N-acyl morpholines - with hypocholesterolaemic and anorectic activity Country Status (1) Cited By (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title JP2013526583A (en) * 2010-05-21 2013-06-24 ãªãµã¼ãã»ãã©ã¤ã¢ã³ã°ã«ã»ã¤ã³ã¹ãã£ãã¥ã¼ã Phenylmorpholine and its analogs

1972
- 1972-01-17 FR FR7201441A patent/FR2168139A1/en not_active Withdrawn

Cited By (2) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title JP2013526583A (en) * 2010-05-21 2013-06-24 ãªãµã¼ãã»ãã©ã¤ã¢ã³ã°ã«ã»ã¤ã³ã¹ãã£ãã¥ã¼ã Phenylmorpholine and its analogs US9617229B2 (en) 2010-05-21 2017-04-11 Research Triangle Institute Phenylmorpholines and analogues thereof Similar Documents Legal Events Date Code Title Description 1978-03-17 ST Notification of lapse

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