Showing content from https://patents.google.com/patent/ES440760A1/en below:
ES440760A1 - Process for the production of imidazolines
ES440760A1 - Process for the production of imidazolines - Google PatentsProcess for the production of imidazolines Info
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Publication number
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ES440760A1
ES440760A1 ES440760A ES440760A ES440760A1 ES 440760 A1 ES440760 A1 ES 440760A1 ES 440760 A ES440760 A ES 440760A ES 440760 A ES440760 A ES 440760A ES 440760 A1 ES440760 A1 ES 440760A1
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Authority
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ES
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Spain
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Prior art keywords
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formula
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compound
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quinoxaline
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positions
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aminoethylthioureido
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Prior art date
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1974-09-06
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Expired
Application number
ES440760A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-09-06
Filing date
1975-09-05
Publication date
1977-04-01
1975-09-05 Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
1977-04-01 Publication of ES440760A1 publication Critical patent/ES440760A1/en
Status Expired legal-status Critical Current
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000002462 imidazolines Chemical class 0.000 title 1
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002540 isothiocyanates Chemical class 0.000 abstract 2
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 β-aminoethylthioureido compound Chemical class 0.000 abstract 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure to prepare quinoxaline and quinazoline derivatives, of formula: **(See formula)** where Q represents a group of formula: **(See formula)** wherein the free valence can be at any of the 5, 6, 7 or 8 positions of the quinoxaline or quinazoline nucleus; (R1) x represents up to three optional substituents at any of the remaining positions 5, 6, 7 or 8, each R1 being a halogen atom or a lower alkyl, lower alkoxy or trifluoromethyl group and x being a number from 0 to 3; R1 represents an optional substituent at any of the 2 or 3 or 2 or 4 positions of the quinoxaline or quinaxoline nucleus, respectively, where R2 is a hydrogen atom or a lower alkyl or lower alkoxy group; characterized in that it comprises heating a thioureido compound of formula Q-NHCSNH2 where Q is defined as above, to produce the corresponding isothiocyanate of formula Q-NCS; reacting the isothiocyanate with ethylenediamine, to form a β-aminoethylthioureido compound of the formula Q-NH-CS-NHCH2CH2NH2; cyclizing the β-aminoethylthioureido compound, to form the compound of formula (I); recovering the latter as a product optionally, converting the product into a pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES440760A 1974-09-06 1975-09-05 Process for the production of imidazolines Expired ES440760A1 (en) Applications Claiming Priority (1) Application Number Priority Date Filing Date Title GB3914374A GB1463520A (en) 1974-09-06 1974-09-06 Process for the production of imidazolines Publications (1) Publication Number Publication Date ES440760A1 true ES440760A1 (en) 1977-04-01 Family ID=10407882 Family Applications (1) Application Number Title Priority Date Filing Date ES440760A Expired ES440760A1 (en) 1974-09-06 1975-09-05 Process for the production of imidazolines Country Status (12) Families Citing this family (16) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same US5198442A (en) * 1989-10-12 1993-03-30 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same US5326763A (en) * 1989-10-12 1994-07-05 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure US5237072A (en) * 1990-02-06 1993-08-17 Allergan, Inc. Method for producing amino-2-imidazoline derivatives US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives US6323204B1 (en) 1993-10-13 2001-11-27 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives DE69431880T2 (en) * 1993-10-13 2003-09-18 Allergan, Inc. USE OF (2-IMIDAZOLIN-2-YL-AMINO) QUINOXALINE DERIVATIVES CA2505836C (en) 2004-05-06 2013-08-27 Alcon Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide RU2285003C1 (en) * 2005-04-29 2006-10-10 ФедеÑалÑное гоÑÑдаÑÑÑвенное ÑниÑаÑное пÑедпÑиÑÑие "ЦенÑÑ Ð¿Ð¾ Ñ
имии лекаÑÑÑвеннÑÑ
ÑÑедÑÑв" (ФÐУРЦХÐС-ÐÐÐХФÐ) Method for preparing 5-bromo-6-[(2-imidazolin-2-yl)amino]quinoxaline l-tartrate WO2015097600A2 (en) 2013-12-24 2015-07-02 Sentiss Pharma Private Limited Topical brimonidine tartrate ophthalmic solution JP6339364B2 (en) * 2013-12-27 2018-06-06 ã«ãºããã¼ããã¼ãºæ ªå¼ä¼ç¤¾ Amorphous brimonidine tartrate and method for producing the same JP6270603B2 (en) * 2014-04-14 2018-01-31 ã«ãºããã¼ããã¼ãºæ ªå¼ä¼ç¤¾ Novel polymorph of brimonidine tartrate and process for producing the same EP4142689A1 (en) 2020-04-29 2023-03-08 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of brinzolamide and brimonidine Family Cites Families (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM
Also Published As Similar Documents Publication Publication Date Title ES411804A1 (en) 1976-05-01 PROCEDURE FOR OBTAINING QUINOXALINE DERIVATIVES AND QUINAZOLINE. ES440760A1 (en) 1977-04-01 Process for the production of imidazolines ES421067A1 (en) 1976-04-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) ES399064A1 (en) 1975-06-01 Diazepine derivatives and process for their production ES320729A1 (en) 1966-05-16 Procedure for the synthesis of new derivatives of antranilic acid. (Machine-translation by Google Translate, not legally binding) ES413252A1 (en) 1976-05-01 Process for the production of 6-piper-azinyl-morphanthridines and related tricyclics ES407730A1 (en) 1976-01-16 Pyrimidones ES404744A1 (en) 1976-01-01 Cephalosporin derivatives ES296634A1 (en) 1964-09-01 Procedure for the production of new heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES432790A1 (en) 1977-02-16 A method for producing derivatives of 2-chloropropic acid. (Machine-translation by Google Translate, not legally binding) ES440438A1 (en) 1977-03-01 Procedure for the preparation of new derivatives of fenilbutazona. (Machine-translation by Google Translate, not legally binding) ES435351A1 (en) 1976-12-01 1-(3-phenylpropyl)-4-furoylpiperazine derivatives GB1097951A (en) 1968-01-03 A process for the manufacture of benzdiaz[1,4]epine derivatives ES446132A1 (en) 1977-06-16 A procedure for the preparation of new derivatives of 2-alkyl (bottom) -2 or 3-cefem-4-carboxylic acid. (Machine-translation by Google Translate, not legally binding) ES393554A1 (en) 1974-11-16 Thiazole derivatives and a process for the manufacture thereof ES422873A1 (en) 1976-05-01 Method for the production of derivatives of 6-aminopenicillanic acid ES404115A1 (en) 1976-01-01 Novel 1-benzoyloxy-2-lower alkylamino-benzocycloalkane derivatives ES325448A1 (en) 1967-02-16 Procedure for producing 4-amino-5-halo-2-benzamide derivatives. (Machine-translation by Google Translate, not legally binding) ES301710A1 (en) 1964-09-16 Procedure for the preparation of new 1,2-diaril-4-alkyl-3,5-dioxo-pirazolidines (Machine-translation by Google Translate, not legally binding) ES419740A1 (en) 1976-09-01 Procedure for the preparation of 2-arilamino-imidazolines- (2) substitute. (Machine-translation by Google Translate, not legally binding) ES432202A1 (en) 1976-11-01 A procedure for the production of derivatives of 1-acil4-alquil substituted-piperazine and -homopiperazina. (Machine-translation by Google Translate, not legally binding) ES412088A1 (en) 1976-06-01 Pyridoquinoline derivatives ES405046A1 (en) 1976-01-16 Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) ES398368A1 (en) 1975-05-16 A procedure for the preparation of new derivatives of 1,2,3,4-tetrahidroisoquinoleina. (Machine-translation by Google Translate, not legally binding) ES425406A1 (en) 1976-06-01 Procedure for preparing derivatives of dibenzo (a, l) ciclohepteno. (Machine-translation by Google Translate, not legally binding)
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