Showing content from https://patents.google.com/patent/ES421067A1/en below:
ES421067A1 - Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding)
ES421067A1 - Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) - Google PatentsProcedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) Info
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Publication number
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ES421067A1
ES421067A1 ES421067A ES421067A ES421067A1 ES 421067 A1 ES421067 A1 ES 421067A1 ES 421067 A ES421067 A ES 421067A ES 421067 A ES421067 A ES 421067A ES 421067 A1 ES421067 A1 ES 421067A1
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Authority
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ES
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Spain
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Prior art keywords
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general formula
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hydrogen
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hal
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chlorine
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imidazolines
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Prior art date
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1972-12-02
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Expired
Application number
ES421067A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-12-02
Filing date
1973-12-01
Publication date
1976-04-01
1973-12-01 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
1976-04-01 Publication of ES421067A1 publication Critical patent/ES421067A1/en
Status Expired legal-status Critical Current
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000002462 imidazolines Chemical class 0.000 title 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 methoxy, hydroxy Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- JCOPITWIWLFFPC-UHFFFAOYSA-N n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class N1CCN=C1NC1=CC=CC=C1 JCOPITWIWLFFPC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the preparation of new substituted 2-phenylamino-imidazolines of the general formula **(See formula)** where R1, R2 and R3, which may be the same or different, signify a hydrogen or fluorine, chlorine or bromine atom, or a methyl, ethyl, methoxy, hydroxy, trifluoromethyl or cyano group and R4 and R5, which can be both the same or different, but cannot be hydrogen at the same time, they mean a hydrogen atom or a straight or branched alcohol chain with up to 12 carbon atoms, as well as their acid addition salts, characterized in that a 2 -phenyl-imidazoline- (2) of the general formula **(See formula)** in which R1, R2 and R3 have the aforementioned meanings, with a halide of the general formula Hal-R4 wherein Hal means a chlorine, bromine or iodine atom and has the above meanings, but does not represent hydrogen, and eventually the 2-phenylamino-imidazoline- (2) formed of the general formula is subsequently reacted **(See formula)** wherein R1, R2, R3 and R4 have the aforementioned meanings, in a second reaction stage, with a halide of the general formula Hal-R5 where Hal means a chlorine, bromine or iodine atom and R5 has the above meanings, but does not represent hydrogen; and eventually the product is transformed into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES421067A 1972-12-02 1973-12-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) Expired ES421067A1 (en) Applications Claiming Priority (1) Application Number Priority Date Filing Date Title DE19722259160 DE2259160A1 (en) 1972-12-02 1972-12-02 NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE, THEIR ACID-ADDITIONAL SALTS AND METHOD FOR MANUFACTURING THE SAME AND THEIR USE AS A MEDICINAL PRODUCT Publications (1) Publication Number Publication Date ES421067A1 true ES421067A1 (en) 1976-04-01 Family ID=5863396 Family Applications (2) Application Number Title Priority Date Filing Date ES421068A Expired ES421068A1 (en) 1972-12-02 1973-12-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) ES421067A Expired ES421067A1 (en) 1972-12-02 1973-12-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) Family Applications Before (1) Application Number Title Priority Date Filing Date ES421068A Expired ES421068A1 (en) 1972-12-02 1973-12-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) Country Status (8) Families Citing this family (9) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title DE2636732A1 (en) * 1976-08-14 1978-02-16 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF DE2830278A1 (en) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF DE2947563A1 (en) * 1979-11-26 1981-06-04 C.H. Boehringer Sohn, 6507 Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF DE2949287A1 (en) * 1979-12-07 1981-06-11 C.H. Boehringer Sohn, 6507 Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF DE3200258A1 (en) * 1982-01-07 1983-07-21 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München SUBSTITUTED 1-BENZOYL-2-PHENYLIMINO IMIDAZOLIDINE, THE ACID ADDITION SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME IT1303672B1 (en) * 1998-07-28 2001-02-23 Nicox Sa NITRATED SALTS OF DRUGS ACTIVE IN BONE DISORDERS EP1333028A1 (en) * 2002-01-31 2003-08-06 Boehringer Ingelheim Pharma GmbH & Co.KG 2'-Halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine derivatives and the use thereof for the treatment of urinary incontinence US6703409B2 (en) 2002-01-31 2004-03-09 Boehringer Ingelheim Pharma Gmbh & Co Kg 2â²-Halo-3â²,5â²-dialkoxyphen-1â²-yl-imino-2-imidazolidine and the use thereof as a drug PT2932968T (en) * 2008-06-09 2018-03-13 Allergan Inc Compound for treating alpha adrenergic mediated conditions
Also Published As Similar Documents Publication Publication Date Title ES385635A1 (en) 1973-10-01 2-(n-allyl-phenylamino)-imidazolines-(2)and salts thereof ES394370A1 (en) 1974-11-16 Pharmacologically active 3-piperazinyl-carbonyloxy-2-pyridyl-isoindolin-1-ones ES417333A1 (en) 1976-02-16 Omega-(4'-(3"-indolyl)-piperidino)-alkyl-arylketones ES405942A1 (en) 1975-07-01 2-phenylimino-imidazolidines,their 2-aniline-2-imidazoline tautomers and salts thereof ES421067A1 (en) 1976-04-01 Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding) ES423233A1 (en) 1976-07-01 2-phenylamino-imidazolines-(2) ES397370A1 (en) 1974-05-16 4-4-alpha-hydroxybenzyl piperidino 4-fluorobutyrophenone derivative ES385634A1 (en) 1973-03-16 2-(n-cycloalkyl-phenylamino)-2-imidazolines-(2) and salts thereof ES440030A1 (en) 1977-02-16 2-aminoindane derivatives ES425216A1 (en) 1976-05-16 Substituted triazolo-1,5-benzodiazepines ES398142A1 (en) 1974-08-01 1-(p-benzamido)-3-methyl-triazenes ES399003A1 (en) 1974-11-01 2-aryl-amino-imidazoline-2 compounds ES401342A1 (en) 1975-02-16 Pyridine derivatives ES435351A1 (en) 1976-12-01 1-(3-phenylpropyl)-4-furoylpiperazine derivatives ES395720A1 (en) 1973-11-16 N-(hydroxy-or methoxy-alkyl)-2-(n'-(hydroxy or methoxy-alkyl)-phenyl-amino)-imidazolines-(2) and salts thereof ES403476A1 (en) 1975-05-01 Procedure for the preparation of 2-arilamino-imidazolines- (2) substitute. (Machine-translation by Google Translate, not legally binding) ES419740A1 (en) 1976-09-01 Procedure for the preparation of 2-arilamino-imidazolines- (2) substitute. (Machine-translation by Google Translate, not legally binding) ES419741A1 (en) 1976-11-16 Procedure for the preparation of 2 asylaminoimidazolines- (2) replaced. (Machine-translation by Google Translate, not legally binding) ES303109A1 (en) 1965-02-16 Procedure for the preparation of imidazo quinazolinas and pirimido quinazolinas. (Machine-translation by Google Translate, not legally binding) ES426874A1 (en) 1976-09-01 Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) ES428624A1 (en) 1977-01-01 Procedure for the preparation of pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) ES426949A1 (en) 1976-07-16 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) ES412886A1 (en) 1976-05-01 A procedure for the preparation of tiazolcarboxilic acid derivatives. (Machine-translation by Google Translate, not legally binding) ES389882A1 (en) 1973-06-01 3-benzazepines and salts thereof ES427622A1 (en) 1976-08-01 Procedure for the preparation of 2-amino-bencil-amines. (Machine-translation by Google Translate, not legally binding)
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