RetroSearch Browse

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://patents.google.com/patent/ES413639A1/en below:

ES413639A1 - Dopamine derivatives - Google Patents

ES413639A1 - Dopamine derivatives - Google PatentsDopamine derivatives Info

Publication number: ES413639A1
Authority: ES; Spain
Prior art keywords: hydrogen; radicals; methyl; methoxy; hydroxy
Prior art date: 1972-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES413639A

Other languages

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-04-12

Filing date

1973-04-12

Publication date

1976-01-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22918877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES413639(A1) "Global patent litigation datasetâ by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1973-04-12 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1976-01-16 Publication of ES413639A1 publication Critical patent/ES413639A1/en

Status Expired legal-status Critical Current

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the preparation of a dopamine derived compound of formula I **(See formula)** where R and R1 are hydrogen or methyl, at least one of the radicals R or R1 being hydrogen; R2 and R3 are hydrogen or hydroxy, at least one of the radicals R2 or R3 being hydroxy; n is 1 or 2 and, when n is 1 and R2 and R3 are both hydroxy, then R or R1 is methyl; and the pharmaceutically acceptable mineral acid addition salts thereof, the process of which is characterized by reacting with hydrobromic acid a compound of formula II **(See formula)** where R and R1 are hydrogen or methyl, at least one of the radicals R or R1 being hydrogen; R2 and R3 are hydrogen or methoxy, at least one of the radicals R2 or R3 being methoxy; n is 1 or 2; and, when n is 1 and R2 and R3 are both methoxy, then R or R1 is methyl and optionally convert it to its pharmaceutically acceptable salts. (Machine-translation by Google Translate, not legally binding)

ES413639A 1972-04-12 1973-04-12 Dopamine derivatives Expired ES413639A1 (en) Applications Claiming Priority (1) Application Number Priority Date Filing Date Title US24346672A 1972-04-12 1972-04-12 Publications (1) Publication Number Publication Date ES413639A1 true ES413639A1 (en) 1976-01-16 Family ID=22918877 Family Applications (1) Application Number Title Priority Date Filing Date ES413639A Expired ES413639A1 (en) 1972-04-12 1973-04-12 Dopamine derivatives Country Status (31) Families Citing this family (19) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title CH585693A5 (en) * 1974-02-08 1977-03-15 Ciba Geigy Ag US4342692A (en) * 1980-10-20 1982-08-03 Usv Pharmaceutical Corporation Pyrrolidines NO822514L (en) * 1981-07-22 1983-01-24 Syntex Inc PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2,5-SUBSTITUTED PYRROLIDE INGREDIENTS JPS6061523A (en) * 1983-09-16 1985-04-09 Shionogi & Co Ltd Oral dobutamine pharmaceutical IL85438A0 (en) * 1987-02-24 1988-07-31 Lilly Co Eli Improvements in or relating to dobutamine salts JPH0383364U (en) * 1989-12-18 1991-08-23 AU658188B2 (en) * 1991-05-20 1995-04-06 Tsumura & Co. Phellodendrine analogs and allergy type IV suppressor containing the same as active ingredient EP0620208B1 (en) * 1993-04-13 1997-07-09 Duphar International Research B.V Production of dobutamine compounds DE69404063T2 (en) * 1993-04-13 1998-01-22 Duphar Int Res Manufacture of dobutamine compounds US7642290B2 (en) 2002-10-03 2010-01-05 Novaremed Limited Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection US7674829B2 (en) 2004-03-26 2010-03-09 Novaremed Limited Compounds for the treatment of AIDS and other viral diseases GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain SG178191A1 (en) 2009-07-31 2012-03-29 Cognition Therapeutics Inc Inhibitors of cognitive decline US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain EP2747759A4 (en) * 2011-08-25 2015-05-13 Cognition Therapeutics Inc Compositions and methods for treating neurodegenerative disease JP6517827B2 (en) 2014-01-31 2019-05-22 ã³ã°ãã·ã§ã³ ã»ã©ãã¥ã¼ãã£ã¯ã¹ï¼ã¤ã³ã³ã¼ãã¬ã¤ããã Isoindoline compositions and methods of treating neurodegenerative diseases CN110869011B (en) 2017-05-15 2024-01-05 èæ ¼å°¼ç³æ²»çè¡ä»½æéå¬å¸ Composition for treating neurodegenerative diseases CN114524734B (en) * 2021-12-27 2024-04-26 åå®ï¼æ¹åï¼å»è¯ç§ææéå¬å¸ Preparation method of dobutamine hydrochloride CN117326958A (en) * 2023-09-21 2024-01-02 é¦å·å¥¥é¸¿è¯ä¸æéè´£ä»»å¬å¸ Preparation method of high-purity dobutamine hydrochloride Family Cites Families (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title US2276619A (en) * 1942-03-17 N-phentlaliphatic-dihtoroxyphentnl

1973
- 1973-03-28 ZA ZA732136A patent/ZA732136B/en unknown
- 1973-04-09 GB GB1683573A patent/GB1392674A/en not_active Expired
- 1973-04-09 CY CY963A patent/CY963A/en unknown
- 1973-04-09 DE DE2317710A patent/DE2317710C2/en not_active Expired
- 1973-04-10 FR FR7312845A patent/FR2182947B1/fr not_active Expired
- 1973-04-10 SE SE7305032A patent/SE399064B/en unknown
- 1973-04-10 IE IE563/73A patent/IE37511B1/en unknown
- 1973-04-11 AT AT318773A patent/AT323719B/en not_active IP Right Cessation
- 1973-04-11 CA CA168,428A patent/CA1018188A/en not_active Expired
- 1973-04-11 DK DK196773A patent/DK142750C/en not_active IP Right Cessation
- 1973-04-11 YU YU00976/73A patent/YU36483B/en unknown
- 1973-04-11 BG BG023268A patent/BG23001A3/en unknown
- 1973-04-11 CH CH1112475A patent/CH580563A5/xx not_active IP Right Cessation
- 1973-04-11 AU AU54385/73A patent/AU472734B2/en not_active Expired
- 1973-04-11 SU SU1908277A patent/SU496719A3/en active
- 1973-04-11 NL NLAANVRAGE7305097,A patent/NL174459C/en not_active IP Right Cessation
- 1973-04-11 BE BE1004956A patent/BE798051A/en not_active IP Right Cessation
- 1973-04-11 KR KR7300573A patent/KR790000113B1/en not_active Expired
- 1973-04-11 CH CH517473A patent/CH569691A5/xx not_active IP Right Cessation
- 1973-04-12 PL PL1973183808A patent/PL94207B1/pl unknown
- 1973-04-12 PL PL1973161874A patent/PL90695B1/pl unknown
- 1973-04-12 ES ES413639A patent/ES413639A1/en not_active Expired
- 1973-04-12 RO RO7383749A patent/RO70892A/en unknown
- 1973-04-12 PH PH14508A patent/PH11041A/en unknown
- 1973-04-12 IL IL42016A patent/IL42016A/en unknown
- 1973-04-12 DD DD73170118A patent/DD107670B3/en unknown
- 1973-04-12 HU HUEI469A patent/HU166213B/hu unknown
- 1973-04-12 CS CS77171A patent/CS190448B2/en unknown
- 1973-04-12 RO RO7374457A patent/RO65105A/en unknown
- 1973-04-12 JP JP48041750A patent/JPS5825656B2/en not_active Expired
- 1973-04-12 AR AR247523A patent/AR203822A1/en active
- 1973-04-12 CS CS732601A patent/CS190406B2/en unknown
- 1973-04-12 HU HUEI552A patent/HU167597B/hu unknown
1978
- 1978-08-10 KE KE2870A patent/KE2870A/en unknown
- 1978-09-07 HK HK501/78A patent/HK50178A/en unknown
- 1978-12-30 MY MY381/78A patent/MY7800381A/en unknown
1979
- 1979-12-28 YU YU3212/79A patent/YU37113B/en unknown
1982
- 1982-08-27 JP JP57149025A patent/JPS58131945A/en active Granted

Also Published As Similar Documents Publication Publication Date Title ES413639A1 (en) 1976-01-16 Dopamine derivatives ES387016A1 (en) 1976-05-01 Isoquinoline derivatives ES439909A1 (en) 1977-08-16 2-thiol-4,5-diphenyloxazole s-derivatives ES447664A1 (en) 1977-06-16 Cardenolide derivatives ES405479A1 (en) 1975-08-16 Benzodiazepin-2-ones ES421182A1 (en) 1976-04-16 PROCEDURE TO PREPARE 1-PHENOXY-3-PHENOXY-ETHYLAMINE-2-PROPANOLES. ES378206A1 (en) 1972-06-01 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof ES418841A1 (en) 1976-03-16 Derivatives of pyridine-3-acetic acid ES419386A1 (en) 1976-07-01 Indenopyrrole derivatives ES412068A1 (en) 1976-01-01 Xylidides ES364980A1 (en) 1971-02-16 A method for preparing new adamantan derivatives. (Machine-translation by Google Translate, not legally binding) ES442612A1 (en) 1978-03-16 Isoquinoline compounds ES461191A1 (en) 1978-06-16 New nn**11piperidinyl*alkyl* aryl carboxysamide derivative ES417269A1 (en) 1976-03-16 3-azetidinylethyl-1-phenyl-2-midazolidinone derivatives GB1108060A (en) 1968-04-03 Indole derivatives and a process for their production ES405080A1 (en) 1975-07-16 Bis-(para-chlorophenoxy)carbinol and ethers thereof ES402551A1 (en) 1975-04-01 A procedure for the preparation of piperazine derivatives. (Machine-translation by Google Translate, not legally binding) ES410009A1 (en) 1975-12-01 Process for preparing 7-acylamino-3-substituted-3-cephem-4- carboxylic acid derivatives ES409555A1 (en) 1976-03-16 A procedure for the obtaining of new derivatives of cefalosporine. (Machine-translation by Google Translate, not legally binding) ES366913A1 (en) 1971-06-16 A procedure for the preparation of therapeutically active substitute cyclohexanes. (Machine-translation by Google Translate, not legally binding) ES427622A1 (en) 1976-08-01 Procedure for the preparation of 2-amino-bencil-amines. (Machine-translation by Google Translate, not legally binding) ES334733A1 (en) 1967-10-16 Procedure for preparing derivatives of acid esters-5halobenzoicos. (Machine-translation by Google Translate, not legally binding) ES379617A1 (en) 1973-01-16 A process for the manufacture of amino acids and derivatives thereof ES385679A1 (en) 1973-08-16 N-arylidene derivatives of erythromycylamine ES382191A1 (en) 1972-10-16 Procedure for the preparation of new derivatives of azepine. (Machine-translation by Google Translate, not legally binding)

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.4