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Showing content from https://patents.google.com/patent/ES278109A1/en below:

ES278109A1 - Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding)

ES278109A1 - Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) - Google PatentsProcedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) Info

Publication number: ES278109A1
Authority: ES; Spain
Prior art keywords: alkyl; radical; lower alkenyl; hydrogen; general formula
Prior art date: 1961-06-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES278109A

Other languages

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

JR Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-06-09

Filing date

1962-06-08

Publication date

1963-01-16

1962-06-08 Application filed by JR Geigy AG filed Critical JR Geigy AG

1963-01-16 Publication of ES278109A1 publication Critical patent/ES278109A1/en

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000007522 mineralic acids Chemical class 0.000 abstract 2
150000007524 organic acids Chemical class 0.000 abstract 2
150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000005277 alkyl imino group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

Abstract

Process for the preparation of new N-heterocyclic compounds, of the general formula I ** (See formula) ** in which X1 and X2 mean both hydrogen atoms or, together, an additional bond, Z means an alkylene radical, straight or branched chain, with 2 to 6 carbon atoms, R1 means an alkyl or lower alkenyl radical, a phenylalkyl radical or the phenyl radical, R2 means hydrogen or an alkyl or lower alkenyl radical, R3 means hydrogen or an alkyl or lower alkenyl radical, and R4 and R5 signify, independently of one another, hydrogen, lower alkyl radicals or lower alkenyl radicals, the alkyl radicals R3 and R4 may also be linked to each other, directly or via an oxygen atom or an alkylimino group, as well as its salts with inorganic and organic acids and its quaternary ammonium compounds, characterized in that a halogenalkylamide of the general formula III is reacted ** (See formula) ** wherein R1, R2, R5, X1, X2 and Z have the meaning expressed above, while "Hal" means chlorine or bromine, with ammonia or with an amine of the general formula IV ** (See formula) ** wherein R3 and R4 have the meaning expressed above, and, if desired, the reaction product obtained is converted, by treatment with an inorganic or organic acid, into a salt or, by reaction with reactive ester of an aliphatic and araliphatic alcohol, in a quaternary ammonium compound. (Machine-translation by Google Translate, not legally binding)

ES278109A 1961-06-09 1962-06-08 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) Expired ES278109A1 (en) Applications Claiming Priority (1) Application Number Priority Date Filing Date Title CH673561A CH396915A (en) 1961-06-09 1961-06-09 Process for the preparation of new N-heterocyclic compounds Publications (1) Publication Number Publication Date ES278109A1 true ES278109A1 (en) 1963-01-16 Family ID=4314204 Family Applications (2) Application Number Title Priority Date Filing Date ES278109A Expired ES278109A1 (en) 1961-06-09 1962-06-08 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES278108A Expired ES278108A1 (en) 1961-06-09 1962-06-08 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) Family Applications After (1) Application Number Title Priority Date Filing Date ES278108A Expired ES278108A1 (en) 1961-06-09 1962-06-08 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) Country Status (6) Families Citing this family (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title AR205239A1 (en) * 1974-07-29 1976-04-12 Searle & Co PROCEDURE FOR THE PREPARATION OF A GROUP OF N- (OMEGA-HEXAMETHYLENIMINE-ALKYLEN C2-C6) -5H-BENZO (B, F) -AZEPINE-5-CARBOZAMIDES

0
- FR FR1332146D patent/FR1332146A/fr not_active Expired
- NL NL279501D patent/NL279501A/xx unknown
1961
- 1961-06-09 CH CH673561A patent/CH396915A/en unknown
1962
- 1962-05-25 GB GB2021662A patent/GB996490A/en not_active Expired
- 1962-06-08 ES ES278109A patent/ES278109A1/en not_active Expired
- 1962-06-08 ES ES278108A patent/ES278108A1/en not_active Expired
- 1962-06-08 BE BE618752A patent/BE618752A/en unknown

Also Published As Similar Documents Publication Publication Date Title ES431056A1 (en) 1976-10-16 N-{8 (Methoxymethyl-furyl)-methyl{9 -morphinans or -6,7-benzomorphans and salts thereof ES400824A1 (en) 1975-11-01 Amidinocarbamates ES278109A1 (en) 1963-01-16 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) GB1029228A (en) 1966-05-11 A method of preparing new quaternary ammonium salts with disinfectant activity ES393934A2 (en) 1974-02-16 Derivatives of theophylline GB964233A (en) 1964-07-22 Derivatives of 5-nitro-2-furylnitrile ES246068A1 (en) 1959-03-16 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES315487A1 (en) 1966-03-01 A procedure for preparing tetrahydro-i, 3,5-oxadiacin-4onas. (Machine-translation by Google Translate, not legally binding) ES301710A1 (en) 1964-09-16 Procedure for the preparation of new 1,2-diaril-4-alkyl-3,5-dioxo-pirazolidines (Machine-translation by Google Translate, not legally binding) ES364725A1 (en) 1970-12-16 Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) ES274908A1 (en) 1962-10-01 Iminodibenzyl derivatives ES246069A1 (en) 1959-03-16 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES386716A1 (en) 1974-01-16 Procedure for the preparation of new derivatives of tiepine. (Machine-translation by Google Translate, not legally binding) ES296119A1 (en) 1964-07-16 Procedure for obtaining new heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES383342A1 (en) 1973-01-01 P-carbamoylethylphenylsulfonyl derivatives ES299449A1 (en) 1964-11-01 Procedure for the preparation of new derivatives of tiepine (Machine-translation by Google Translate, not legally binding) ES277887A1 (en) 1963-01-16 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) ES360859A1 (en) 1970-07-16 Procedure for the preparation of new derivatives of tiazepine. (Machine-translation by Google Translate, not legally binding) ES272000A1 (en) 1962-06-16 Procedure for the preparation of new derivatives of cumarina (Machine-translation by Google Translate, not legally binding) ES383346A1 (en) 1973-01-01 Procedure for the preparation of new derivatives of the p-aminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) GB804089A (en) 1958-11-05 Process for the preparation of cyclohexanone derivatives ES300123A1 (en) 1964-11-16 A procedure for the preparation of new derivatives of piperazine replaced asymmetrically (Machine-translation by Google Translate, not legally binding) ES383341A1 (en) 1973-01-01 P-aminoalkylbenzenesulfonamide derivatives ES278243A1 (en) 1963-01-16 Procedure for the preparation of new N-heterocyclic compounds (Machine-translation by Google Translate, not legally binding) GB1118426A (en) 1968-07-03 Triazolium salts and a process for their production

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