The invention discloses a kind of heart sound feature extracting method based on wavelet singular entropy, and it is related to a kind of processing method of cardiechema signals.Cardiechema signals sample frequency of the present invention is 8000Hzï¼Utilize Hilbert-Huangï¼HHTï¼Heart sound envelope is extracted, is then segmented again based on heart sound envelope so as to obtain one section of complete cardiechema signals, both including s1, s2 and s3, s4ï¼6 rank wavelet decompositions are carried out to segmentation cardiechema signals using DB6 as morther waveletï¼Singular value decomposition is all carried out to the contour signal and detail signal obtained after wavelet transformation, respectively obtains respective singular value matrixï¼Calculate respective singular entropyï¼Then weighting obtains the characteristic value of cardiechema signals.Wavelet singular entropy is introduced into cardiechema signals feature extraction by the present invention, is not only able to highlight the feature of cardiechema signals HFS complexity, and can determine the respective frequencies of low frequency signal, and cardiechema signals day part is quantitatively describedï¼Reduce the data operation quantity of cardiechema signals processing, improve the arithmetic speed of heart sound characteristics extraction.
Description Translated from Chinese ä¸ç§åºäºå°æ³¢å¥å¼çµçå¿é³ç¹å¾æåæ¹æ³A Heart Sound Feature Extraction Method Based on Wavelet Singular Entropyææ¯é¢åtechnical field
æ¬åæå±äºä¿¡å·å¤çé¢åï¼å ·ä½æ¶åä¸ç§åºäºå°æ³¢å¥å¼çµçå¿é³ç¹å¾æåæ¹æ³ãThe invention belongs to the field of signal processing, in particular to a heart sound feature extraction method based on wavelet singular entropy.
èæ¯ææ¯Background technique
å¿é³ä¿¡å·æ¯å©ç¨ä¿¡å·éé设å¤ééå°çåèªå¿èç声é³ï¼å ¶ä¸å å«éè¦çå¿è¡ç®¡çç©ä¿¡æ¯ãå¿é³ä¿¡å·å¨ä¸åçäººèº«ä¸æçå®å ¨ä¸åçç¹å¾å¹¶ä¸å ·ææé«çç¨³å®æ§ãHeart sound signal is the sound from the heart collected by signal acquisition equipment, which contains important cardiovascular biological information. Heart sound signals have completely different characteristics in different people and have extremely high stability.
ç®åå½å å¤å¾å¤ç§ç 人åå°è¯äºå¤ç§çæ¹æ³æ¥åæå¿é³ä¿¡å·ãGauthieréç¨å¿«éå éå¶åæ¢ï¼FFTï¼åæå¿é³ä¿¡å·(Gauthier D, Akay Y M, Paden R G, et al. SpectralAnalysis of Heart Sounds Associated with Coronary Occlusions [C].6thInternational Special Topic Conference on Information Technology Applicationsin Biomedicine,2007:49-52)ãå éå¶åæ¢è½ç¶å ·æè¯å¥½çæ§è´¨ï¼è½å¤å®ç°æ¶åå°é¢åç¸äºè½¬æ¢ãä½ä»å éå¶åæ¢å ¬å¼å¯ä»¥çåºï¼å®æ¯ä»¥æ£å¼¦æ³¢åå ¶é«æ¬¡è°æ³¢ä¸ºæ ååºçï¼å æ¤å®æ¯å¯¹ä¿¡å·çä¸ç§æ»ä½ä¸çåæï¼å ·æåä¸çå±é¨å®ä½è½åï¼ä¹å°±æ¯å¨æ¶åçè¯å¥½å®ä½æ¯ä»¥é¢åçå ¨é¨ä¿¡å·åæä¸ºä»£ä»·çï¼å¯¹é¢åçè¯å¥½å®ä½æ¯ä»¥æ¶åçå ¨é¨ä¿¡å·åæä¸ºä»£ä»·çï¼å ç«å¶åæ¢çé¢çè°±ä¸è¦ä¹é¢çæ¯åç¡®çèæ¶é´æ¯æ¨¡ç³çï¼è¦ä¹æ¶é´æ¯åç¡®çèé¢çæ¯æ¨¡ç³çï¼å®ä¸å¯è½åæ¶å¨æ¶ååé¢åé½å ·æè¯å¥½çå®ä½çè½åãèå¿é³ä¿¡å·ä¸»è¦éä¸å¨s1ås2ä¸ï¼ç¸å¯¹æ´ä¸ªå¿é³å¨æs1ås2æ¯ä¸¤ä¸ªç¸å¯¹çæçæ¶é´æ®µï¼å æ¤ä½¿ç¨å éå¶åæ¢å¯¹å¿é³ä¿¡å·è¿è¡åæå¹¶ä¸æ¯ä¸ä¸ªå¾å¥½çéæ©ãAt present, many researchers at home and abroad have tried various methods to analyze heart sound signals. Gauthier uses Fast Fourier Transform (FFT) to analyze heart sound signals (Gauthier D, Akay YM, Paden RG, et al. Spectral Analysis of Heart Sounds Associated with Coronary Occlusions [C]. 6thInternational Special Topic Conference on Information Technology Applications in Biomedicine, 2007: 49-52). Although Fourier transform has good properties, it can realize mutual conversion from time domain to frequency domain. However, it can be seen from the Fourier transform formula that it is based on the sine wave and its higher harmonics, so it is an overall analysis of the signal and has a single local positioning capability, that is, in time Good positioning in the frequency domain is at the expense of all signal analysis in the frequency domain, and good positioning in the frequency domain is at the cost of all signal analysis in the time domain. In the frequency spectrum of the Fourier transform, either the frequency is accurate and the time is ambiguous. , or the time is accurate but the frequency is ambiguous, it is impossible to have a good positioning ability in both the time domain and the frequency domain. The heart sound signals are mainly concentrated on s1 and s2, which are two relatively short time periods compared to the entire heart sound cycle s1 and s2, so it is not a good choice to use Fourier transform to analyze the heart sound signals.
æ¤å¤è¿æå ¶ä»åçè°±å¯åº¦ï¼æ ·æ¬çµæ¹æ³åæå¿é³ä¿¡å·ãä½è¿äºæ¹æ³é½åå¨åèªç缺ç¹ï¼åçè°±æ¯ä»¥ä¿¡å·æä»é«æ¯åå¸å设为åæï¼åæ¶ä¸¢å¤±äºä¿¡å·çç¸ä½ä¿¡æ¯ï¼è¿ä¼¼çµè®¡ç®è¿ç¨ä¸åå¨èªèº«æ°æ®æ®µçæ¯è¾,导è´ç»æåå¨åå·®ãIn addition there are other power spectral density, sample entropy methods for analyzing heart sound signals. However, these methods have their own shortcomings: the power spectrum is based on the assumption that the signal obeys the Gaussian distribution, and the phase information of the signal is lost at the same time; there is a comparison of its own data segments in the approximate entropy calculation process, which leads to deviations in the results.
åæå 容Contents of the invention
æ¬åæçç®çæ¯è§£å³ç®åå¨å¿é³ä¿¡å·ç¹å¾æåä¸åå¨çé®é¢ï¼æä¾ä¸ç§åºäºå°æ³¢å¥å¼çµçå¿é³ç¹å¾æåæ¹æ³ãThe purpose of the present invention is to solve the existing problems in the heart sound signal feature extraction at present, and provide a heart sound feature extraction method based on wavelet singular entropy.
å®ç°æ¬åæçææ¯æ¹æ¡æ¯ï¼å ¶ç¹å¾å¨äºè¯¥æ¹æ³å æ¬ä¸é¢6个è¿ç¨ãThe technical solution for realizing the present invention is: it is characterized in that the method includes the following 6 processes.
a)å¿é³ééãå¿é³ä¿¡å·éæ ·é¢ç为4000Hzãa) Heart sound collection. The heart sound signal sampling frequency is 4000Hz.
bï¼å¿é³å ç»æåååæ®µãå¨å®é ééä¸å¾å°çå¿é³è¿é¿å æ¤éè¦å¯¹å¿é³è¿è¡å ç»æåï¼å¨æ¤éç¨çå ç»æåæ¹æ³æ¯å©ç¨å¸å°ä¼¯ç¹âé»åæ¢ï¼HHTï¼æåå¿é³å ç»ï¼ç¶åååºäºå¿é³å ç»è¿è¡å段ä»èå¾å°ä¸æ®µå®æ´çå¿é³ä¿¡å·ï¼æ¢å æ¬s1,s2ï¼ås3,s4ãb) Heart sound envelope extraction and segmentation. The heart sound obtained in the actual collection is too long, so it is necessary to extract the envelope of the heart sound. The envelope extraction method used here is to use the Hilbert-Huang Transform (HHT) to extract the heart sound envelope, and then based on the heart sound envelope. Segmentation to obtain a complete heart sound signal, including s1, s2, and s3, s4.
cï¼å°æ³¢åæ¢ãéç¨DB6ä½ä¸ºæ¯å°æ³¢å¯¹å段å¿é³ä¿¡å·è¿è¡5é¶å°æ³¢åè§£ãc) Wavelet transform. Using DB6 as the mother wavelet, the segmental heart sound signal was decomposed by 5th order wavelet.
dï¼å¥å¼å¼åè§£ãå 为å¿é³ä¿¡å·çé¢çæå主è¦éä¸å¨300 Hz以ä¸ï¼æä»¥å¨æ¤éè¦å¯¹å°æ³¢åæ¢åå¾å°çè½®å»ä¿¡å·CAï¼ä½é¢ä¿¡æ¯ï¼åç»èä¿¡å·CDï¼é«é¢ä¿¡æ¯ï¼é½è¿è¡å¥å¼å¼åè§£ãåå«å¾å°åèªçå¥å¼å¼ç©éµSaåSdãå¥å¼å¼åè§£æ ¼å¼å¦ä¸ãd) Singular value decomposition. Because the frequency components of the heart sound signal are mainly concentrated below 300 Hz, it is necessary to perform singular value decomposition on both the contour signal CA (low frequency information) and the detail signal CD (high frequency information) obtained after wavelet transformation. The respective singular value matrices Sa and Sd are obtained respectively. The singular value decomposition format is as follows.
å ¶ä¸ï¼è为ç©éµAçå ¨é¨éé¶å¥å¼å¼ãin ,and are all non-zero singular values of matrix A.
eï¼è®¡ç®å¥å¼çµãæSaåSdåå«ä»£å ¥ä¸å¼å¾å°è½®å»ä¿¡å·CAçå¥å¼çµHaåç»èä¿¡å·CDçå¥å¼çµHdãe) Calculate the singular entropy. Substitute Sa and Sd into the following formula to obtain the singular entropy Ha of the contour signal CA and the singular entropy Hd of the detail signal CD.
å ¶ä¸ï¼ãin , .
fï¼è®¡ç®ç¹å¾å¼ãæå ææè½®å»ä¿¡å·CAçå¥å¼çµHaåç»èä¿¡å·CDçå¥å¼çµHdè¿è¡åå¹¶ï¼å¾å°æç»ç¹å¾å¼ãf) Calculate the eigenvalues. The singular entropy Ha of the contour signal CA and the singular entropy Hd of the detail signal CD are combined by weighting to obtain the final feature value.
æè¿°çå¿é³ç¹å¾å¼éç¨çæ¯å¿é³å°æ³¢åè§£åçå¥å¼çµï¼å¹¶å°ä¸¤è æç §å æçå½¢å¼ç»åãThe heart sound eigenvalue adopts the singular entropy after the heart sound wavelet decomposition, and combines the two in a weighted form.
æ¬åæå ·æç§¯æå°ææï¼æ¬åæçä¸ç§åºäºå°æ³¢å¥å¼çµçå¿é³ç¹å¾æåæ¹æ³ï¼ä¸ä½è½å¤å¯ä»¥å¸æ¾å¿é³ä¿¡å·é«é¢é¨åå¤æåº¦çç¹å¾ï¼èä¸å¯ä»¥ç¡®å®ä½é¢ä¿¡å·ç对åºé¢çï¼å¹¶å¯¹å¿é³ä¿¡å·åæ¶æ®µè¿è¡å®éæè¿°ãæ¬åæå°å°æ³¢å¥å¼çµå¼å ¥å¿é³ä¿¡å·ç¹å¾æåä¸ï¼åå°äºå¿é³ä¿¡å·å¤ççæ°æ®è¿ç®éï¼æé«äºå¿é³ç¹å¾å¼æåçè¿ç®é度ãThe present invention has positive effects: a heart sound feature extraction method based on wavelet singular entropy of the present invention can not only highlight the characteristics of the complexity of the high-frequency part of the heart sound signal, but also determine the corresponding frequency of the low-frequency signal, and analyze each heart sound signal. Quantitative description of time period. The invention introduces the wavelet singular entropy into the feature extraction of the heart sound signal, reduces the data calculation amount of the heart sound signal processing, and improves the calculation speed of the heart sound feature value extraction.
éå¾è¯´æDescription of drawings
å¾1ä¸ºéæ ·çå¿é³ä¿¡å·ï¼Fig. 1 is the heart sound signal of sampling;
å¾2 ä¸ºåæ®µçå¿é³ä¿¡å·ï¼Figure 2 is a segmented heart sound signal;
å¾3为 å°æ³¢åæ¢åå¿é³è½®å»ä¿¡å·ï¼Fig. 3 is the heart sound contour signal after wavelet transform;
å¾4ä¸ºå°æ³¢åæ¢åå¿é³ç»èä¿¡å·ï¼Fig. 4 is the heart sound detail signal after wavelet transform;
å¾5为æ¬åææµç¨ç¤ºæå¾ï¼Fig. 5 is a schematic flow chart of the present invention;
å ·ä½å®æ½æ¹å¼detailed description
ï¼å®æ½ä¾1ï¼(Example 1)
æ¬å ·ä½å®æ½æ¹å¼çä¸ç§åºäºå°æ³¢å¥å¼çµçå¿é³ç¹å¾æåæ¹æ³ï¼å ·ä½è¿ç¨å¦å¾1æç¤ºï¼è¯´æå¦ä¸ï¼A kind of heart sound feature extraction method based on wavelet singular entropy of this specific embodiment, concrete process as shown in Figure 1, explains as follows:
ä¸ãå¿é³ééãå¿é³ä¿¡å·éæ ·é¢ç为8000Hzãå¾2为ééå°çæ£å¸¸å¿é³ä¿¡å·ã1. Heart sound collection. The heart sound signal sampling frequency is 8000Hz. Figure 2 is the collected normal heart sound signal.
äºãå¿é³å段ãééå°çå¿é³è¿é¿å æ¤éè¦å¯¹å¿é³è¿è¡å ç»æåï¼éè¿è¿ä¸ªè¿ç¨ä»èå¾å°ä¸æ®µå®æ´çå¿é³ä¿¡å·ï¼æ¢å æ¬s1,s2ås3,s4ã卿¤éç¨çå ç»æåæ¹æ³æ¯å©ç¨å¸å°ä¼¯ç¹âé»åæ¢ï¼HHTï¼æåå¿é³å ç»ï¼ç¶åååºäºå¿é³å ç»è¿è¡å段ãå¾3为ç»è¿HHTåæ¢ï¼æåå°çä¸ä¸ªç¬ç«å®æ´çæ£å¸¸å¿é³ä¿¡å·ã2. Segmentation of heart sounds. The collected heart sound is too long, so it is necessary to extract the envelope of the heart sound. Through this process, a complete heart sound signal is obtained, including s1, s2 and s3, s4. The envelope extraction method used here is to use the Hilbert-Huang transform (HHT) to extract the heart sound envelope, and then segment based on the heart sound envelope. Fig. 3 is an independent and complete normal heart sound signal extracted after HHT transformation.
ä¸ãå°æ³¢åæ¢ãæ¬ç ç©¶éç¨DB6ä½ä¸ºæ¯å°æ³¢å¯¹å¿é³ä¿¡å·è¿è¡åè§£ãå°æ³¢å解尺度ä¸éæ ·é¢çåå°æ³¢åºæå ³ãæ ¹æ®å°æ³¢çéæ ·å®çï¼å¯¹äºä¸ä¸ªé¿åº¦ä¸ºMçåå§éæ ·ä¿¡å·ï¼ç¦»æ£å°æ³¢åè§£æå¤å¯ä»¥æä¿¡å·åè§£ælog2M个é¢ç级ï¼å æ¤å°æ³¢åè§£çå°ºåº¦æ¯æéçå¹¶ä¸åè§£ç级æ°è¶å¤,åå ¶æéç计ç®éè¶å¤§æä»¥åºæ ¹æ®å®é åºç¨åéè¦æ¥éæ©å°æ³¢çå解尺度ã卿¬æä¸éç¨çå¿é³ä¿¡å·éæ ·é¢ç为4000Hzï¼æ ¹æ®å°æ³¢å带å«ä¹ï¼ä¸åçå°æ³¢ç³»æ°ä»£è¡¨ä¸å颿®µä¿¡æ¯ï¼æ¯å¦1é¶åè§£çç»èä¿¡å·cd1表示çé¢ç为ï¼2000 Hz ~4000 Hzï¼2é¶åè§£çç»èä¿¡å·cd2表示çé¢ç为ï¼1000 Hz ~2000 Hzâ¦â¦ãèéè¿çæ¶å éå¶åæ¢åæå¿é³ä¿¡å·ï¼åç°ç¬¬ä¸å¿é³s1çé¢çæå主è¦éä¸å¨50 Hz ~150 Hzèå´å ï¼è第äºå¿é³s2çé¢çæå主è¦éä¸å¨50 Hz ~200 Hzèå´å , 250 Hz ~300 Hzèå´å åºç°ç¬¬äºä¸ªå°å³°å¼æä»¥å¨æ¤éæ©è¿è¡6å±åæ¢ãè¿æ ·å¾å°6é¶åè§£çè½®å»ä¿¡å·ca6表示çé¢ç为ï¼0 Hz ~125 Hz, 6é¶åè§£çç»èä¿¡å·cd6表示çé¢ç为ï¼125 Hz ~250HzãThree, wavelet transform. In this study, DB6 was used as the mother wavelet to decompose the heart sound signal. The scale of wavelet decomposition is related to sampling frequency and wavelet basis. According to the wavelet sampling theorem, for an original sampling signal of length M, discrete wavelet decomposition can decompose the signal into log 2 M frequency levels at most, so the scale of wavelet decomposition is limited and the more stages of decomposition, the more The greater the amount of calculation required, the wavelet decomposition scale should be selected according to the actual application and needs. The heart sound signal sampling frequency used in this paper is 4000Hz. According to the meaning of wavelet subbands, different wavelet coefficients represent different frequency band information. The frequency represented by the detail signal cd2 is: 1000 Hz ~ 2000 Hz... . By analyzing the heart sound signal through short-time Fourier transform, it is found that the frequency components of the first heart sound s1 are mainly concentrated in the range of 50 Hz to 150 Hz, while the frequency components of the second heart sound s2 are mainly concentrated in the range of 50 Hz to 200 Hz. , a second small peak appears in the range of 250 Hz ~ 300 Hz, so here we choose to perform 6-layer transformation. In this way, the frequency represented by the contour signal ca6 of the 6th order decomposition is: 0 Hz ~ 125 Hz, and the frequency represented by the detail signal cd6 of the 6th order decomposition is: 125 Hz ~ 250 Hz.
å¾4ä¸ºå°æ³¢åæ¢åå¿é³è½®å»ä¿¡å·ï¼å¾5ä¸ºå°æ³¢åæ¢åå¿é³ç»èä¿¡å·ãFig. 4 is the heart sound contour signal after wavelet transformation; Fig. 5 is the heart sound detail signal after wavelet transformation.
åãå¥å¼å¼åè§£ãå 为å¿é³ä¿¡å·çé¢çæå主è¦éä¸å¨300 Hz以ä¸ï¼æä»¥å¨æ¤éè¦å¯¹cd6ï¼ca6è¿è¡å¥å¼å¼åè§£ï¼ä»£å ¥ä¸å¼ãåå«å¾å°åèªçå¥å¼å¼ç©éµSdåSaã4. Singular value decomposition. Because the frequency components of the heart sound signal are mainly concentrated below 300 Hz, it is necessary to perform singular value decomposition on cd6 and ca6, and substitute them into the following formula. The respective singular value matrices Sd and Sa are obtained respectively.
äºã计ç®å¥å¼çµãæSdåSaåå«ä»£å ¥ä¸å¼å¾å°6é¶åè§£çè½®å»ä¿¡å·ca6çå¥å¼çµHaå6é¶åè§£çç»èä¿¡å·cd6çå¥å¼çµHdã5. Calculate the singular entropy. Substitute Sd and Sa into the following formula respectively to obtain the singular entropy Ha of the contour signal ca6 decomposed by the 6th order and the singular entropy Hd of the detail signal cd6 decomposed by the 6th order.
å ¶ä¸ï¼ãin , .
å ãæåç¹å¾å¼ãä¸æå ææè½®å»ä¿¡å·çå¥å¼çµHaåç»èä¿¡å·çå¥å¼çµHdè¿è¡åå¹¶ï¼å¾å°æç»ç¹å¾å¼ã6. Extract eigenvalues. The singular entropy Ha of the contour signal and the singular entropy Hd of the detail signal are combined without weighting to obtain the final eigenvalue.
Claims (2)1. a kind of heart sound feature extracting method based on wavelet singular entropy, it is characterised in that this method includes following 6 processesï¼
A) heart sound gathers, and cardiechema signals sample frequency is 4000Hzï¼
bï¼Heart sound envelope extraction and segmentation, the heart sound obtained in actual acquisition is long therefore needs to carry heart sound progress envelope Take, the envelope extraction method used herein is to utilize Hilbert-Huangï¼HHTï¼Heart sound envelope is extracted, is then based on the heart again Sound envelope is segmented so as to obtain one section of complete cardiechema signals, both including s1, s2 and s3, s4ï¼
cï¼Wavelet transformation, 5 rank wavelet decompositions are carried out to segmentation cardiechema signals as morther wavelet using DB6ï¼
dï¼Singular value decomposition, because the frequency content of cardiechema signals is concentrated mainly on 300 below Hz, need herein to small The contour signal CA obtained after wave conversionï¼Low-frequency informationï¼With detail signal CDï¼High-frequency informationï¼Singular value decomposition is all carried out, respectively Respective singular value matrix Sa and Sd is obtained, singular value decomposition form is shown in formula 1ï¼
ï¼1ï¼
Wherein, andFor matrix A Whole non-zero singular valuesï¼
eï¼Singular entropy is calculated, Sd and Sa is substituted into formula 2 respectively obtains contour signal CA singular entropy Ha and detail signal CD Singular entropy Hdï¼
ï¼2ï¼
Wherein,ï¼
fï¼Characteristic value is calculated, contour signal CA singular entropy Ha and detail signal CD singular entropy Hd are merged by weighting, Obtain final characteristic value.
A kind of 2. described heart sound feature extracting method based on wavelet singular entropy before being required according to right 1, it is characterised in thatï¼The heart Sound characteristic value is using heart sound wavelet decomposition rear profile signal and the singular entropy of detail signal, and the shape by both according to weighting Formula combines.
CN201410015681.9A 2014-01-14 2014-01-14 A kind of heart sound feature extracting method based on wavelet singular entropy Expired - Fee Related CN104778342B (en) Priority Applications (1) Application Number Priority Date Filing Date Title CN201410015681.9A CN104778342B (en) 2014-01-14 2014-01-14 A kind of heart sound feature extracting method based on wavelet singular entropy Applications Claiming Priority (1) Application Number Priority Date Filing Date Title CN201410015681.9A CN104778342B (en) 2014-01-14 2014-01-14 A kind of heart sound feature extracting method based on wavelet singular entropy Publications (2) Family ID=53619803 Family Applications (1) Application Number Title Priority Date Filing Date CN201410015681.9A Expired - Fee Related CN104778342B (en) 2014-01-14 2014-01-14 A kind of heart sound feature extracting method based on wavelet singular entropy Country Status (1) Families Citing this family (4) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title CN105877706A (en) * 2016-03-31 2016-08-24 æµåå¤§å¦ Heart-sound enhancement method based on improved spectral subtraction CN107480637B (en) * 2017-08-15 2019-08-30 éåºå¤§å¦ Heart failure staging method based on heart sound characteristics CN110346157A (en) * 2018-04-04 2019-10-18 å½ç½å®å¾½ççµåæéå ¬å¸çµåç§å¦ç ç©¶é¢ A kind of application method that wavelet singular entropy is detected in piler cyclic breakdown CN110101407B (en) * 2019-04-16 2021-09-07 ååå¸èå¤§å¦ Fetal heart sound denoising method, system, device and storage medium Citations (1) * Cited by examiner, â Cited by third party Publication number Priority date Publication date Assignee Title CN202005762U (en) * 2011-03-07 2011-10-12 æµåå¤§å¦ Program-controlled amplifying and filtering device for heart sound signal acquisitionGranted publication date: 20171215
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