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CN104161760A - Compound anesthetic for racoon dogs as well as preparation method and application thereof

实施例4貉用复合麻醉剂的制备Embodiment 4 The preparation of compound anesthetic for raccoon dogs

20℃无菌条件下准确称量右美托咪啶5mg和咪达唑仑45mg，将之混合，放入一个灭菌密闭性良好的20ml安瓶内，再加入10ml灭菌注射用水混合均匀，并放在涡旋振荡器(50HZ，25w，1500rpm)上震荡20s，共震荡10次，直至肉眼检查无未溶解粉末，即得。Accurately weigh 5mg of dexmedetomidine and 45mg of midazolam under aseptic conditions at 20°C, mix them, put them into a 20ml ampoule with good sterilized airtightness, and then add 10ml of sterile water for injection and mix evenly. And put it on a vortex shaker (50HZ, 25w, 1500rpm) for 20s, and shake it 10 times in total, until there is no undissolved powder by visual inspection, that is to say.

实验例1复合麻醉剂的组分筛选实验Component screening experiment of experimental example 1 compound anesthetic

1、实验方法1. Experimental method

将不同药物组合，具体为右美托咪啶+咪达唑仑，氯胺酮+咪达唑仑，氯胺酮+右美托咪啶，右美托咪啶+乙酰丙嗪，赛拉嗪+咪达唑仑；组中药物剂量分别为右美托咪啶40μg/kg、咪达唑仑0.5mg/kg、氯胺酮8mg/kg、乙酰丙嗪0.02mg/kg、赛拉嗪1mg/kg。Combinations of different drugs, specifically dexmedetomidine + midazolam, ketamine + midazolam, ketamine + dexmedetomidine, dexmedetomidine + acepromazine, xylazine + midazolam The drug doses in the group were dexmedetomidine 40 μg/kg, midazolam 0.5 mg/kg, ketamine 8 mg/kg, acepromazine 0.02 mg/kg, and xylazine 1 mg/kg.

每组药物分别麻醉实验动物貉，每组5只，观察镇痛、镇静和肌松效果，以表1为标准进行评分。Each group of drugs anesthetized experimental animal raccoon dogs respectively, 5 animals in each group, observed the effects of analgesia, sedation and muscle relaxation, and scored according to Table 1.

表1 麻醉评分标准Table 1 Anesthesia scoring criteria

2、实验结果2. Experimental results

实验结果显示(表2-4)，将各种药物进行组合，其中右美托咪啶+咪达唑仑的组合镇痛效果显著优于其他组合(P<0.05)，且良好镇痛时间持续较长(50min)；在镇静方面右美托咪啶+咪达唑仑的组合镇静最佳显著优于右美托咪啶+乙酰丙嗪和赛拉嗪+咪达唑仑的组合(P<0.05)，良好镇静时间达(60min)，在麻醉后10～50min时间段镇静效果达到满分；在麻醉期间的右美托咪啶+咪达唑仑的组合肌松效果得分较其他四组高，在10min-50min内各时间点都是满分，在部分时间点与其他组相比，差异显著(P<0.05)。The experimental results showed (Table 2-4) that among the combinations of various drugs, the analgesic effect of the combination of dexmedetomidine + midazolam was significantly better than that of other combinations (P<0.05), and the good analgesic time lasted Longer (50min); in terms of sedation, the combination of dexmedetomidine + midazolam is the best combination of sedation significantly better than the combination of dexmedetomidine + acepromazine and xylazine + midazolam (P< 0.05), the good sedation time was up to (60min), and the sedative effect reached the full score in the period of 10-50min after anesthesia; the combined muscle relaxation score of dexmedetomidine + midazolam during anesthesia was higher than that of the other four groups, All time points within 10min-50min were full marks, and compared with other groups at some time points, the difference was significant (P<0.05).

综合镇痛、镇静和肌松效果可以得出，右美托咪啶+咪达唑仑的组合明显优于其它的组合。Based on the analgesic, sedative and muscle relaxing effects, it can be concluded that the combination of dexmedetomidine + midazolam is significantly better than other combinations.

表2 组方研究—不同药物组合镇痛效果比较 Table 2 Prescription research—comparison of analgesic effects of different drug combinations

注：同列比较，肩标大写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)；同行比较，肩标小写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)。Note: Compared with the same column, the same uppercase letters on the shoulder labels indicate no significant difference (P>0.05), different shoulder labels indicate significant differences (P<0.05); peer comparisons, the same small letters on the shoulder labels indicate no significant difference (P>0.05) , Different letters on the shoulder label indicate significant difference (P<0.05).

表3 组方研究—不同药物组合镇静效果比较 Table 3 Prescription research—comparison of sedative effects of different drug combinations

注：统计分析标记同表2。Note: The marks for statistical analysis are the same as those in Table 2.

表4 组方研究—不同药物组合肌松效果比较 Table 4 Prescription Research—Comparison of Muscle Relaxation Effects of Different Drug Combinations

注：统计分析标记同表2。Note: The marks for statistical analysis are the same as those in Table 2.

实验例2复合麻醉剂的组方用量筛选实验The dosage screening experiment of the prescription of experimental example 2 compound anesthetics

在实验例1基础上，将右旋美托咪啶、咪达唑仑按两因素三水平(表5)测定各种组合的麻醉效果，具体结果见表6。On the basis of Experimental Example 1, the anesthetic effects of various combinations of dexmedetomidine and midazolam were determined according to two factors and three levels (Table 5). The specific results are shown in Table 6.

表5 因素水平表Table 5 Factor level table

表6 组分剂量的确定(两种药物复合注射后20min进行评分，n＝5)Table 6 Determination of component doses (scored 20min after compound injection of two drugs, n=5)

注：数据比较肩标不同大写字母表示差异显著(P＜0.05)；肩标相同大写字母表示差异不显著(P＞0.05)。Note: Data comparison with different capital letters on the shoulders indicates significant difference (P<0.05); the same uppercase letters on the shoulders indicate no significant difference (P>0.05).

用由右旋美托咪啶和咪达唑仑组成的不同组合皮下注射貉，观察生物反射、镇静、镇痛、肌松等情况，对不同组合的麻醉作用进行综合分析和评价，初步筛选出右旋美托咪啶的用量优选为0.05mg/kg，咪达唑仑的用药量优选为0.40-0.45mg/kg，最优选为0.45mg/kg。Using different combinations of dexmedetomidine and midazolam to subcutaneously inject raccoon dogs, observe the biological reflex, sedation, analgesia, muscle relaxation, etc., conduct comprehensive analysis and evaluation on the anesthetic effects of different combinations, and initially screen out The dosage of dexmedetomidine is preferably 0.05 mg/kg, and the dosage of midazolam is preferably 0.40-0.45 mg/kg, most preferably 0.45 mg/kg.

实验例3本发明貉用复合麻醉剂与其他四种复合麻醉剂对貉麻醉效果观察Experimental Example 3 Observation of the anesthesia effect of raccoon dog with compound anesthetic for raccoon dog and other four compound anesthetics of the present invention

1、实验动物及试剂1. Experimental animals and reagents

貉场健康貉子25只，购自红旗乡赵潘清狐貉养殖场，体重7.83±0.42kg，年龄9-10月龄，均为检疫合格的健康动物，各项生理指标正常，精神状况良好。试验动物均于相同环境饲养，统一喂食。试验前禁食12h，禁水5h以上。25 healthy raccoon dogs in the raccoon farm were purchased from the fox and raccoon farm in Zhaopanqing, Hongqi Township. The weight was 7.83±0.42kg, and the age was 9-10 months. They were all healthy animals that passed the quarantine inspection, with normal physiological indicators and good mental condition. All experimental animals were reared in the same environment and fed uniformly. Fasting for 12 hours and water for more than 5 hours before the test.

犬眠宝(购自青岛汉河动植物药业有限公司，批号2012022701)；犬眠宝是东北农业大学外科教研室研制的一种犬科动物专用复合麻醉剂，由静松灵、强痛宁、哌利啶、氯胺酮按照2.5:0.12:0.5:0.25组成(按合剂中单一注射剂体积计算)。Quanmianbao (purchased from Qingdao Hanhe Animal and Plant Pharmaceutical Co., Ltd., batch number 2012022701); Quanmianbao is a special compound anesthetic for canines developed by the Department of Surgery, Northeast Agricultural University. Ridine and ketamine are composed according to 2.5:0.12:0.5:0.25 (calculated according to the volume of a single injection in the mixture).

舒泰50；舒泰是法国维克公司生产的复合麻醉药，有舒泰20(20mg/ml)、舒泰50(50mg/ml)和舒泰100(100mg/ml)3种浓度。主要成分是替来他明和唑拉西泮，按1:1混合制成。Sutai 50; Sutai is a compound anesthetic produced by the French company Vic, with three concentrations of Sutai 20 (20mg/ml), Sutai 50 (50mg/ml) and Sutai 100 (100mg/ml). The main ingredients are teletamine and zolazepam, which are prepared by mixing 1:1.

速眠新Ⅱ(购自长春军需大学兽医研究所)；速眠新是一种复合麻醉制剂，又称846合剂，由长春军需大学兽医研究所研制的全身麻醉药，是由盐酸双氢埃托啡(DHM99)、氟哌啶醇、保定宁制成的复方制剂；每毫升速眠新含保定宁60mg，盐酸双氢埃托啡4μg，氟哌啶醇2.5mg。Sumianxin Ⅱ (purchased from the Veterinary Research Institute of Changchun Military Quartermaster University); Sumianxin is a compound anesthetic preparation, also known as 846 mixture, a general anesthetic developed by the Veterinary Research Institute of Changchun Military Quartermaster University. A compound preparation made of morphine (DHM99), haloperidol, and Baodingning; each milliliter of Sumianxin contains 60 mg of Baodingning, 4 μg of dihydroetorphine hydrochloride, and 2.5 mg of haloperidol.

舒眠宁注射液(购自南京农业大学小动物疾病研究室，批号20130701)；舒眠宁注射液是2011年由南京农业大学小动物疾病研究室研制，由氯胺酮、赛拉嗪和咪达唑仑三种药物混合而成的一种新型小动物复合麻醉制剂；氯胺酮(8g/100ml)、赛拉嗪(0.9g/100ml)和咪达唑仑(0.2g/100ml)。Shumianning Injection (purchased from the Small Animal Disease Research Laboratory of Nanjing Agricultural University, batch number 20130701); Shumianning Injection was developed by the Small Animal Disease Research Laboratory of Nanjing Agricultural University in 2011, composed of ketamine, xylazine and midazole A new small animal compound anesthesia preparation made by mixing three drugs; ketamine (8g/100ml), xylazine (0.9g/100ml) and midazolam (0.2g/100ml).

硫酸阿托品注射液(购自吉林省华牧动物保健品有限公司，批号130506)；Atropine sulfate injection (purchased from Jilin Province Huamu Animal Health Products Co., Ltd., batch number 130506);

右美托咪啶原粉(购自深圳达艾森科技有限公司，批号130718)；Dexmedetomidine powder (purchased from Shenzhen Daaisen Technology Co., Ltd., batch number 130718);

咪达唑仑原粉(购自上海世锋生物科技有限公司，批号131104)；Midazolam former powder (purchased from Shanghai Shifeng Biotechnology Co., Ltd., batch number 131104);

谷草转氨酶测试盒(购自南京建成生物工程研究所，批号：20131129)；Aspartate aminotransferase test kit (purchased from Nanjing Jiancheng Institute of Bioengineering, batch number: 20131129);

谷丙转氨酶测试盒(购自南京建成生物工程研究所，批号：20131130)；Alanine aminotransferase test kit (purchased from Nanjing Jiancheng Institute of Bioengineering, batch number: 20131130);

碱性磷酸酶测试盒(购自南京建成生物工程研究所，批号：20131127)；Alkaline phosphatase test kit (purchased from Nanjing Jiancheng Institute of Bioengineering, batch number: 20131127);

血尿素氮测试盒(购自南京建成生物工程研究所，批号：20131129)；Blood urea nitrogen test kit (purchased from Nanjing Jiancheng Bioengineering Research Institute, batch number: 20131129);

肌酐测试盒(购自南京建成生物工程研究所，批号：20131128)；Creatinine test box (purchased from Nanjing Jiancheng Institute of Bioengineering, batch number: 20131128);

地塞米松磷酸钠注射液(购自郑州卓峰制药有限公司，批号137043C)。Dexamethasone sodium phosphate injection (purchased from Zhengzhou Zhuofeng Pharmaceutical Co., Ltd., batch number 137043C).

2、实验方法2. Experimental method

2.1动物分组及麻醉2.1 Animal grouping and anesthesia

以貉场25只健康貉作为实验动物，随机分成5组，每组5只；一组(Q组)以0.2ml/kg剂量肌肉注射犬眠宝；二组(Z组)以0.15ml/kg剂量肌肉注射舒泰50；三组(SX组)以0.1ml/kg剂量肌肉注射速眠新Ⅱ；四组(SN组)以0.1ml/kg剂量静脉注射舒眠宁；五组(Y组)以0.1ml/kg剂量肌肉注射本发明实施例4制备的貉用复合麻醉剂。Taking 25 healthy raccoon dogs as experimental animals in the raccoon farm, they were randomly divided into 5 groups, 5 animals in each group; one group (group Q) was intramuscularly injected with Quanmianbao at a dose of 0.2ml/kg; the second group (group Z) was injected with 0.15ml/kg Intramuscular injection of Shutai 50; the third group (SX group) intramuscular injection of Sumianxin II at a dose of 0.1ml/kg; the fourth group (SN group) intravenous injection of Shumianning at a dose of 0.1ml/kg; five groups (Y group) The compound anesthetic for raccoon dogs prepared in Example 4 of the present invention was injected intramuscularly at a dose of 0.1 ml/kg.

麻醉方法：在麻醉前10min，以0.25ml/kg皮下注射浓度为0.2mg/ml硫酸阿托品注射液；随后五组分别注射相应麻醉制剂。当貉出现翻正反射消失时记为麻醉开始时间(0min)。Anesthesia method: 10 minutes before anesthesia, subcutaneous injection of 0.2 mg/ml atropine sulfate injection at 0.25 ml/kg; then the five groups were injected with corresponding anesthetic preparations. When the righting reflex disappears in the raccoon dog, it is recorded as the start time of anesthesia (0 min).

2.2监测指标2.2 Monitoring indicators

(1)麻醉过程生理监测指标监测时间：麻醉前，进入麻醉期后0、5、10、20、30、40、50和60min。(1) Monitoring time of physiological monitoring indicators during anesthesia: before anesthesia, 0, 5, 10, 20, 30, 40, 50 and 60 minutes after entering the anesthesia period.

1)一般指标监测1) General indicator monitoring

体温(T)：用Philips呼吸循环监护仪体温探头插入实验动物直肠内测量；Body temperature (T): Insert the temperature probe of the Philips respiratory cycle monitor into the rectum of the experimental animal for measurement;

心率(HR)：用Philips呼吸循环监护仪探头夹在舌下静脉进行监测；Heart rate (HR): Monitored by clamping the Philips respiratory and circulation monitor probe to the sublingual vein;

镇痛、镇静、肌松：以表1为标准进行评分，在各时间点分别对各项测试进行监测；Analgesia, sedation, and muscle relaxation: score according to Table 1, and monitor each test at each time point;

诱导时间：从注射麻醉制剂到实验动物翻正反射刚消失，用秒表记录时间；Induction time: from the injection of anesthetic preparations to the disappearance of the righting reflex of the experimental animals, record the time with a stopwatch;

麻醉时间：从翻正反射刚消失到翻正反射恢复，用秒表记录时间；Anesthesia time: from the moment the righting reflex disappears to the recovery of the righting reflex, record the time with a stopwatch;

苏醒时间：从翻正反射恢复到可自行走路，用秒表记录时间。Awakening time: From the recovery of righting reflex to self-walking, record the time with a stopwatch.

2)呼吸系统指标监测2) Monitoring of respiratory system indicators

貉麻醉后，进行气管插管，然后将装置连接到PL3516B49多导生理监护仪。After the raccoon was anesthetized, the trachea was intubated, and then the device was connected to a PL3516B49 polychannel physiological monitor.

监测指标为：呼吸频率(RR)、呼吸末CO₂浓度(PetCO₂)、每分通气量(MV)、潮气量(TV)。The monitoring indicators are: respiratory rate (RR), end-tidal CO ₂ concentration (PetCO ₂ ), minute ventilation (MV), and tidal volume (TV).

3)循环系统指标监测3) Monitoring of circulatory system indicators

脉搏血氧饱和度(SpO₂)：将Datex呼吸监护仪传感探头夹在试验动物舌头上进行监测。Pulse oxygen saturation (SpO ₂ ): the sensing probe of the Datex respiratory monitor was clamped on the tongue of the test animal for monitoring.

无创血压：将Datex呼吸监护仪袖套套在试验动物前肢肘关节处进行监测，包括：收缩压(SBP)、舒张压(DBP)和平均动脉压(MAP)。Non-invasive blood pressure: Put the Datex respiratory monitor cuff on the elbow joint of the animal's forelimb to monitor, including: systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP).

4)心电图监测4) ECG monitoring

操作方法：将PL3516B49多导生理监护仪上NEG、EARTH和POS三个电极上的传感针头分别插入右前肢、右后肢和左后肢皮下，进行监测心电图。注意各条联线不能交叉。Operation method: Insert the sensor needles on the NEG, EARTH and POS electrodes on the PL3516B49 multi-conductor physiological monitor into the subcutaneous of the right forelimb, right hindlimb and left hindlimb respectively to monitor the electrocardiogram. Note that the connecting lines cannot cross.

(2)血常规检测(2) Blood routine test

采血时间点：麻醉前，进入麻醉期后0、1、2、4h。Blood collection time points: before anesthesia, 0, 1, 2, and 4 hours after entering the anesthesia period.

操作方法：在以上时间点分别用采血针采取少量血样，用迈瑞BC-2600Vet兽用全自动血液细胞分析仪进行检测，并打印出结果。Operation method: Take a small amount of blood samples with blood collection needles at the above time points, test with Mindray BC-2600Vet veterinary automatic blood cell analyzer, and print out the results.

(3)肝功、肾功检测(3) Liver and kidney function testing

采血时间点：麻醉前，进入麻醉期后0、1、2、4、8、12、24、48、72h。Blood collection time points: before anesthesia, 0, 1, 2, 4, 8, 12, 24, 48, 72 hours after entering the anesthesia period.

操作方法：在以上时间点分别用真空采血管采取血样3ml，用低速自动平衡离心机以3000r/min将血样离心10min。取上层血清，放入冰箱-20℃层，备用。Operation method: Take 3ml of blood samples with vacuum blood collection tubes at the above time points, and centrifuge the blood samples with a low-speed automatic balancing centrifuge at 3000r/min for 10min. Take the serum from the upper layer, put it in the -20°C layer of the refrigerator, and set aside.

肝功、肾功检测方法：谷丙转氨酶、谷草转氨酶、碱性磷酸酶、肌酐、尿素氮五种试剂盒分别按照说明书操作，用TU-1810紫外可见分光光度计对各样品进行检测，并记录各个结果。Liver function and kidney function test methods: five kits of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, and urea nitrogen were operated according to the instructions, and each sample was tested with a TU-1810 ultraviolet-visible spectrophotometer, and recorded individual results.

2.3数据统计方法2.3 Data statistics method

数据结果用平均值±标准差表示，采用SPSS18.0进行数据分析整理。P＜0.05为差异显著，P<0.01为差异极显著。The data results are mean ± standard deviation Said that SPSS 18.0 was used for data analysis and arrangement. P<0.05 means significant difference, and P<0.01 means extremely significant difference.

3、实验结果3. Experimental results

3.1麻醉评分3.1 Anesthesia score

3.1.1镇痛评分3.1.1 Analgesic score

实验结果显示(表7)，进入麻醉期后，0min-60min各时间点Q组、Z组、SX组和SX得分相似，组间比较差异不显著(P>0.05)；Y组在0min-60min各时间点得分较其他四组高，在10min-50min内各时间点都是满分，同一时间点与其他组相比，差异显著(P<0.05)。The experimental results showed (Table 7) that after entering the anesthesia period, the scores of Q group, Z group, SX group and SX at each time point of 0min-60min were similar, and there was no significant difference between the groups (P>0.05); The scores at each time point were higher than those of the other four groups, and all time points were full marks within 10min-50min. Compared with other groups at the same time point, the difference was significant (P<0.05).

表7 麻醉镇痛评分结果 Table 7 Anesthesia and analgesia score results

注：同行比较，肩标大写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)；同列比较，肩标小写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)。Note: Compared with peers, the same uppercase letters on the shoulders indicate no significant difference (P>0.05), and different shoulder letters indicate significant differences (P<0.05); compared with the same column, the same lowercase letters on the shoulders indicate no significant difference (P>0.05) , Different letters on the shoulder label indicate significant difference (P<0.05).

——表示无数据。——Indicates no data.

3.1.2镇静评分3.1.2 Sedation score

实验结果显示(表8)，进入麻醉状态后，组间比较，Y组在0～10min与其他各组存在差异显著(P<0.05)，且Y组这种良好镇静时间持续最长，直到监测结束。组内比较，只有Y组在监测期间镇静效果最为稳定(P>0.05)。The experimental results showed (Table 8) that after entering the anesthesia state, there was a significant difference between the groups at 0-10 minutes between the Y group and the other groups (P<0.05), and the good sedation time of the Y group lasted the longest until monitoring Finish. Compared within the group, only group Y had the most stable sedation effect during the monitoring period (P>0.05).

表8 麻醉镇静评分结果 Table 8 Results of anesthesia and sedation scores

注：统计分析标记同表7。Note: The marks for statistical analysis are the same as those in Table 7.

3.1.3肌松评分3.1.3 Muscle relaxation score

实验结果显示(表9)，进入麻醉状态后，Q组与Y组肌松状态好于其他组，在各时间点得分相似，比较差异不显著(P>0.05)；但Q组良好肌松时间只维持到40min，短于Y组。The experimental results showed (Table 9) that after entering the anesthesia state, the muscle relaxation state of the Q group and the Y group was better than that of other groups, and the scores at each time point were similar, and the difference was not significant (P>0.05); but the good muscle relaxation time of the Q group Only maintained to 40min, shorter than the Y group.

表9 麻醉肌松评分结果 Table 9 Results of anesthesia muscle relaxation score

注：统计分析标记同表7。Note: The marks for statistical analysis are the same as those in Table 7.

3.2麻醉时间监测结果3.2 Anesthesia time monitoring results

实验结果显示(表10)，进入麻醉期后，SX组诱导时间最长，与Z组和SN组相比差异显著(P<0.05)，Z组诱导时间最短；SX组麻醉时间最长，Q组和Y组麻醉时间相差不多，差异不显著(P>0.05)，Z组与SN组比较差异不显著(P>0.05)；苏醒时间Y组最短，Y组、SN组和SX组相比，苏醒时间差异不显著(P>0.05)。The experimental results showed (Table 10) that after entering the anesthesia period, the SX group had the longest induction time, which was significantly different from the Z group and the SN group (P<0.05), and the Z group had the shortest induction time; the SX group had the longest anesthesia time, and the Q group had the longest induction time. Anesthesia time between group Y and group Y was similar, the difference was not significant (P>0.05), group Z and group SN had no significant difference (P>0.05); recovery time was the shortest in group Y, group Y, group SN and group SX compared with There was no significant difference in recovery time (P>0.05).

表10 麻醉时间监测结果(min，n＝5)Table 10 Anesthesia time monitoring results (min, n=5)

注：同行比较，肩标大写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)。Note: Compared with peers, the same uppercase letters on the shoulder labels indicate no significant difference (P>0.05), and different shoulder labels indicate significant differences (P<0.05).

3.3麻醉效果综合监测结果3.3 Comprehensive monitoring results of anesthesia effect

3.3.1麻醉期常规临床指标监测3.3.1 Routine clinical index monitoring during anesthesia

3.3.1.1体温监测3.3.1.1 Body temperature monitoring

实验结果显示(表11)，各组进入麻醉状态后，随着麻醉时间延长，体温总体呈下降趋势，其中Q组、Z组和Y组体温下降明显，到麻醉结束时分别下降1.74℃、1.13℃与2.1℃，Q组在50min-60min时，与基础值比较，差异显著(P<0.05)，Z组在30min-60min时，与基础值比较，差异显著，Y组在30min-60min与基础值比较，差异显著；SX组在10min时体温稍有升高，随后下降。SN组体温下降缓慢，变化幅度小，30min-60min时与基础值比较，差异显著(P<0.05)。组间各时间点进行比较，差异均不显著(P>0.05)。The experimental results showed (Table 11) that after each group entered the anesthesia state, with the prolongation of the anesthesia time, the body temperature generally showed a downward trend. Among them, the body temperature of the Q group, Z group and Y group dropped significantly, and dropped by 1.74 ° C and 1.13 ℃ and 2.1℃, the Q group at 50min-60min, compared with the basic value, the difference is significant (P<0.05), Z group at 30min-60min, compared with the basic value, the difference is significant, Y group at 30min-60min and the basic value The difference was significant; the body temperature of SX group increased slightly at 10 minutes, and then decreased. The body temperature of the SN group dropped slowly and the range of change was small. Compared with the basic value at 30min-60min, the difference was significant (P<0.05). There was no significant difference between the groups at each time point (P>0.05).

表11 体温监测结果(℃，n＝5)Table 11 Body temperature monitoring results (°C, n=5)

注：*表示为组内不同时间点与基础值比较，P<0.05为差异显著；Note: * indicates the comparison between different time points in the group and the basic value, P<0.05 means significant difference;

同一时间点五组进行组间比较，肩标字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)；At the same time point, the five groups were compared among the groups. The same letter on the shoulder label indicates no significant difference (P>0.05), and different letters on the shoulder label indicates significant difference (P<0.05);

——表示无数据。——Indicates no data.

3.3.1.2呼吸率监测3.3.1.2 Respiration rate monitoring

实验结果显示(表12)，进入麻醉期后，Q组、Z组和SX组在0min时，RR明显升高，与基础值比较，差异不显著(P>0.05)，各组分别超过基础值的15％、11％和20％。随后，从麻醉10min开始，呼吸数下降明显，与基础值比较，差异显著(P<0.05)。SN组在麻醉后0min-10min，RR下降很明显，从20min时，缓慢升高。Y组RR在各时间点变化不大，差异不显著(P>0.05)。Y组与SN组比较，在50min-60min差异显著(P<0.05)。The experimental results show (Table 12) that after entering the anesthesia period, the RR of the Q group, Z group and SX group increased significantly at 0 min, compared with the base value, the difference was not significant (P>0.05), each group exceeded the base value 15%, 11% and 20% of . Subsequently, from 10 minutes of anesthesia, the respiratory rate decreased significantly, compared with the base value, the difference was significant (P<0.05). In the SN group, the RR decreased significantly from 0 min to 10 min after anesthesia, and slowly increased from 20 min. The RR of group Y did not change much at each time point, and the difference was not significant (P>0.05). Compared with group Y and group SN, there was a significant difference at 50min-60min (P<0.05).

表12 呼吸率监测结果(次/分钟，n＝5)Table 12 Respiration rate monitoring results (times/minute, n=5)

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.1.3心率监测3.3.1.3 Heart rate monitoring

实验结果显示(表13)，各组在进入麻醉状态后，五组HR均在0min时升高，与基础值比较，分别升高37％、72％、12％、19％和15％，只有Q组、Z组和SN组差异显著(P<0.05)，Q组和SX组从5min后HR呈下降趋势，Z组和SN组分别从50min和30min开始HR升高；Z组在各时间点与其他组比较，差异显著(P<0.05)，Q组和SX组在各时间点差异不显著，SN组和Y组在40-50min内差异显著(P<0.05)。Experimental result shows (table 13), each group is after entering anesthesia state, five groups of HR all increase at 0min, compare with base value, increase respectively 37%, 72%, 12%, 19% and 15%, only Group Q, group Z, and group SN were significantly different (P<0.05). HR in group Q and group SX showed a downward trend after 5 minutes, and group Z and group SN increased HR from 50 minutes and 30 minutes respectively; Compared with other groups, the difference was significant (P<0.05), Q group and SX group had no significant difference at each time point, SN group and Y group had significant difference within 40-50min (P<0.05).

表13 心率监测结果(次/分钟，n＝5)Table 13 Heart rate monitoring results (times/minute, n=5)

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.1.4脉搏血氧饱和度监测结果3.3.1.4 Pulse oximetry monitoring results

实验结果显示(表14)，进入麻醉期后，五组SpO₂均可保持在85％以上，Y组SpO₂所受的影响最为轻微，基本可保持在95％以上，且变化范围不大。SX组在20min-60min内呈持续下降趋势。SN组在5min时，与0min比较差异显著(P<0.05)，其他时间变化范围不大，在貉正常生理范围内；SN组与Y组比较，在5min-30min内，差异显著(P<0.05)。Q组和Z组在麻醉各时间点变化较大，但均在正常生理范围内，不存在统计学差异(P>0.05)。The experimental results showed (Table 14) that after entering the anesthesia period, the SpO ₂ of the five groups could be kept above 85%, and the SpO ₂ of the Y group was the least affected, basically maintaining above 95%, and the range of change was not large. The SX group showed a continuous downward trend within 20min-60min. The difference between SN group and 0 min was significant at 5 minutes (P<0.05), and the range of other time changes was not large, within the normal physiological range of raccoon dogs; the difference between SN group and Y group was significant (P<0.05) between 5 minutes and 30 minutes ). The Q group and Z group changed greatly at each time point of anesthesia, but they were all within the normal physiological range, and there was no statistical difference (P>0.05).

表14 血氧饱和度(SpO₂)监测结果(％，n＝5)Table 14 Blood oxygen saturation (SpO ₂ ) monitoring results (%, n=5)

注：同行比较，肩标大写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)；同列比较，肩标小写字母相同表示差异不显著(P>0.05)，肩标字母不同表示差异显著(P<0.05)。Note: Compared with peers, the same uppercase letters on the shoulders indicate no significant difference (P>0.05), and different shoulder letters indicate significant differences (P<0.05); compared with the same column, the same lowercase letters on the shoulders indicate no significant difference (P>0.05) , Different letters on the shoulder label indicate significant difference (P<0.05).

3.3.2呼吸系统指标监测3.3.2 Monitoring of respiratory system indicators

3.3.2.1呼吸末CO₂浓度监测结果3.3.2.1 Monitoring results of end-tidal _CO2 concentration

实验结果显示(表15)，貉进入麻醉状态后，Z组和Y组在整个麻醉过程中均呈下降趋势，Y组对呼吸末CO₂浓度影响最为轻微，各时间点之间浮动范围小，无统计学差异(P>0.05)。Q组、SX组和SN组在5min时有一过性升高，分别升高了18.5mmHg、3.2mmHg和19.15mmHg，Q组在5min-60min各时间点差异显著(P<0.05)，SN组在5min-20min各时间点差异显著(P<0.05)，随后呈下降趋势；Q组与其余四组比较差异显著(P<0.05)，Z组、SX组和SN组在各时间点比较差异不显著(P>0.05)。The experimental results showed (Table 15) that after the raccoon dog entered the anesthesia state, both groups Z and Y showed a downward trend throughout the anesthesia process, and group Y had the slightest effect on the end-tidal _CO2 concentration, and the fluctuation range between each time point was small. There was no statistical difference (P>0.05). The Q group, SX group and SN group had a transient increase at 5 minutes, which increased by 18.5mmHg, 3.2mmHg and 19.15mmHg respectively. There were significant differences at each time point from 5min to 20min (P<0.05), and then showed a downward trend; Q group had significant differences compared with the other four groups (P<0.05), and Z group, SX group and SN group had no significant differences at each time point (P>0.05).

表15 呼吸末CO₂浓度监测结果(mmHg，n＝5)Table 15 Monitoring results of _end -tidal CO concentration (mmHg, n=5)

注：统计分析标记同表14。Note: The symbols for statistical analysis are the same as those in Table 14.

3.3.2.2每分通气量监测结果3.3.2.2 Minute ventilation monitoring results

实验结果表明(表16)，Y组在几组中MV最高，这说明该组对每分钟通气量的影响最为轻微，Y组在30min时降至最低(P<0.05)，随后又缓慢升高。Z组MV缓慢升高，10min-40min内各时间点差异显著(P<0.05)。Q组和SN组MV在麻醉初始阶段呈下降趋势，分别下降到1.24L/min和2.25L/min，随后缓慢升高，到40min时MV最高，两组在各时间点差异均显著(P<0.05)。SX组在整个麻醉过程中呈下降趋势，到50min时降至最低，为1.2L/min。The experimental results show (Table 16) that group Y has the highest MV among several groups, which shows that this group has the slightest influence on the minute ventilation, and group Y reaches the lowest level at 30 minutes (P<0.05), and then increases slowly . The MV in group Z increased slowly, and there were significant differences at each time point within 10min-40min (P<0.05). The MV of group Q and group SN showed a downward trend at the initial stage of anesthesia, falling to 1.24 L/min and 2.25 L/min, respectively, and then increasing slowly, reaching the highest MV at 40 minutes, and the differences between the two groups at each time point were significant (P< 0.05). The SX group showed a downward trend throughout the anesthesia process, and reached the lowest level at 50 minutes, which was 1.2 L/min.

表16 每分通气量监测结果(L/min，n＝5)Table 16 Minute ventilation monitoring results (L/min, n=5)

注：统计分析标记同表14。Note: The symbols for statistical analysis are the same as those in Table 14.

3.3.2.3潮气量监测结果3.3.2.3 Tidal volume monitoring results

实验结果表明(表17)，Q组和Y组TV在麻醉后逐渐降低，分别在40min和30min时降至最低值192.28ml和183.71ml，随后开始逐渐升高。Z组和SN组在麻醉初期，TV先下降，到40min时又升高，仅SN组在30min-40min内各时间点与5min比较，差异显著(P<0.05)。SX组TV在10min时先一过性升高，随后缓慢下降，在10min、30min和40min内各时间点与5min比较，差异显著(P<0.05)。The experimental results showed (Table 17) that the TV in groups Q and Y decreased gradually after anesthesia, and reached the lowest values of 192.28ml and 183.71ml at 40min and 30min, respectively, and then gradually increased. At the initial stage of anesthesia, TV in group Z and SN decreased first, and then increased at 40 minutes. Only in group SN, there was a significant difference between 30 minutes and 40 minutes compared with 5 minutes (P<0.05). TV in SX group increased transiently at 10 minutes, and then decreased slowly. Compared with 5 minutes at each time point in 10 minutes, 30 minutes and 40 minutes, the difference was significant (P<0.05).

表17 潮气量监测结果(ml，n＝5)Table 17 Tidal volume monitoring results (ml, n=5)

注：统计分析标记同表14。Note: The symbols for statistical analysis are the same as those in Table 14.

3.3.3循环系统指标监测3.3.3 Monitoring of circulatory system indicators

3.3.3.1收缩压监测结果3.3.3.1 Systolic blood pressure monitoring results

实验结果显示(表18)，貉进入麻醉状态后，各组在0min-5min内SBP升高，随后呈下降趋势；其中，Z组和SN组在40min-60min时，SBP有缓慢回升，并趋于稳定；Y组除0min-5min外，其余各时间点之间浮动范围不大，差异不显著(P>0.05)。Q组和SX组相比较，各时间点差异不显著；在0min-5min内，Z组SBP升高最明显，为49.8％，Q组和Y组升高较少，分别为8.22％和16.39％；在10min-60min内，Y组与Q组、SX组各时间点相比，差异显著(P<0.05)。The experimental results showed (Table 18) that after the raccoon dog entered the anesthesia state, the SBP of each group increased within 0min-5min, and then showed a downward trend; among them, the SBP of the Z group and SN group rose slowly at 40min-60min, and tended to decrease. In group Y, except for 0min-5min, the range of fluctuations between the other time points was not large, and the difference was not significant (P>0.05). Compared with group Q and group SX, there was no significant difference at each time point; within 0min-5min, the increase of SBP in group Z was the most obvious, which was 49.8%, and the increase in group Q and group Y was less, 8.22% and 16.39% respectively ; Within 10min-60min, the Y group was significantly different from the Q group and SX group at each time point (P<0.05).

表18 收缩压(SBP)监测结果(mmHg，n＝5)Table 18 Systolic blood pressure (SBP) monitoring results (mmHg, n=5)

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.3.2舒张压监测结果3.3.3.2 Diastolic blood pressure monitoring results

实验结果表明(表19)，各组进入麻醉状态后，在0min-5min内DBP略有升高，其中Z组升高最明显，为40.7％，随后，各组DBP呈下降趋势，但Z组和SN组在40min-60min时，DBP有所回升；Y组在10min后，DBP变化幅度不大，在60min时降至最低。Experimental result shows (table 19), after each group enters anesthesia state, in 0min-5min, DBP increases slightly, and wherein Z group raises the most obviously, is 40.7%, subsequently, each group DBP is on the decline trend, but Z group And SN group, DBP rebounded at 40min-60min; Y group, DBP did not change much after 10min, and fell to the lowest at 60min.

表19 舒张压(DBP)监测结果(mmHg，n＝5)Table 19 Diastolic blood pressure (DBP) monitoring results (mmHg, n=5)

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.3.3平均动脉压3.3.3.3 Mean arterial pressure

实验结果显示(表20)，各组进入麻醉状态后，在0min-5min内MAP升高，随后缓慢下降，Q组在40min时降至最低，为75.32mmHg，随后又缓慢升高，麻醉各时间点与基础值比较，差异不显著(P>0.05)；Z组和SN组在30min时下降最多，随后开始升高，并趋于稳定；SX组和Y组在麻醉初期MAP分别升高21.37mmHg和21.14mmHg，与基础值比较，差异显著(P<0.05)，但均在貉生理范围内变化。The experimental results show (Table 20) that after each group entered the anesthesia state, the MAP increased within 0min-5min, and then decreased slowly. The Q group decreased to the lowest level at 40min, which was 75.32mmHg, and then increased slowly. Compared with the baseline value, the difference was not significant (P>0.05); Z group and SN group decreased the most at 30 minutes, then began to increase, and tended to be stable; SX group and Y group increased by 21.37mmHg at the initial stage of anesthesia and 21.14mmHg, compared with the basic value, the difference was significant (P<0.05), but they all changed within the physiological range of raccoon dogs.

表20 平均动脉压(MAP)监测结果(mmHg，n＝5)Table 20 Mean arterial pressure (MAP) monitoring results (mmHg, n=5)

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.4心电图监测结果3.3.4 ECG monitoring results

3.3.4.1P波、R波和T波监测结果3.3.4.1 P wave, R wave and T wave monitoring results

实验结果显示(表21)，五组进入麻醉状态后，Q组、Z组和SN组P波持续时间在20min时一过性升高，分别升高99.07％、8.21％和12.43％，随后缓慢下降，其中Q组20min-30min各时间点与10min相比，差异显著(P<0.05)；SX组在10min-50min内一直持续升高，在60min时下降；Y组P波持续时间在整个麻醉期缓慢降低，在各时间点不存在统计学差异。The experimental results show (Table 21), after the five groups entered the anesthesia state, the P wave duration of the Q group, the Z group and the SN group increased transiently at 20 minutes, respectively increasing by 99.07%, 8.21% and 12.43%, and then slowly Compared with 10min at each time point of 20min-30min in Q group, the difference was significant (P<0.05); SX group continued to increase within 10min-50min, and decreased at 60min; There was no statistically significant difference at each time point.

SX组和SN组R波电压在麻醉后，分别在30min和20min降至最低，并且分别与各自10min相比，差异显著(P<0.05)，随后升高；Q组R波电压持续升高，在50min时升至最高，为2.88602mV，在30min-50min内各时间点与10min相比，差异显著。Z组R波电压在麻醉期不规律，在30min时，差异显著；Y组在整个麻醉期持续下降，但降低幅度不大，在各时间段不存在统计学差异。After anesthesia, the R wave voltage of SX group and SN group decreased to the lowest at 30 minutes and 20 minutes respectively, and the difference was significant compared with the respective 10 minutes (P<0.05), and then increased; the R wave voltage of Q group continued to rise, It rose to the highest at 50min, which was 2.88602mV. Compared with 10min at each time point within 30min-50min, the difference was significant. The R wave voltage in group Z was irregular during the anesthesia period, and the difference was significant at 30 minutes; the group Y continued to decrease throughout the anesthesia period, but the decrease was not large, and there was no statistical difference in each time period.

Q组和Z组T波电压在麻醉后，分别在20min和30min降至最低，随后缓慢升高，其中Q组在30min-50min时各时间点与10min相比，差异显著(P<0.05)；SX组、SN组和Y组T波电压先升高，随后下降，并趋于稳定。After anesthesia, the T wave voltage of group Q and group Z decreased to the lowest at 20 minutes and 30 minutes respectively, and then increased slowly, and the difference between group Q and 10 minutes at each time point between 30 minutes and 50 minutes was significant (P<0.05); The T wave voltage of SX group, SN group and Y group increased first, then decreased, and tended to be stable.

3.3.4.2P-R段、Q-T段、S-T段和QRS波的监测结果3.3.4.2 Monitoring results of P-R segment, Q-T segment, S-T segment and QRS wave

实验结果显示(表22)，进入麻醉期后，各组P-R段持续时间均升高，其中Q组、SN组和Y组均在30min时升至最高，为0.08380s、0.04856s和0.05605s，随后缓慢下降并趋于稳定，各时间点与10min比较，差异不显著；Z组P-R段持续时间，在20min时呈一过性升高，随后呈缓慢下降趋势，在整个麻醉过程中，波动范围不大；SX组持续时间一直升高，到60min时升高0.02987s，60min与10min比较，差异显著(P<0.05)。五组间各时间点进行比较，不存在统计学差异(P>0.05)。The experimental results show (Table 22) that after entering the anesthesia period, the duration of the P-R segment in each group increased, and the Q group, SN group and Y group all rose to the highest at 30 minutes, which were 0.08380s, 0.04856s and 0.05605s, Then it decreased slowly and tended to be stable. Compared with 10min at each time point, the difference was not significant; the duration of P-R segment in group Z showed a transient increase at 20min, and then showed a slow downward trend. During the entire anesthesia process, the fluctuation range Not much; the duration of the SX group increased all the time, and increased by 0.02987s at 60 minutes, and the difference between 60 minutes and 10 minutes was significant (P<0.05). Comparing each time point among the five groups, there was no statistical difference (P>0.05).

Q组和Y组Q-T段持续时间先升高随后降低，其中Q组在30min-50min内各时间点与10min比较，差异显著(P<0.05)，Y组各时间点波动范围不大，不存在统计学差异，但两组在30min-50min内各时间点比较，差异显著(P<0.05)；SX组Q-T段持续时间变化较大，在40min-50min内各时间点与10min比较，差异显著(P<0.05)；Z组和SN组持续下降，都在40min时降至最低，分别为0.16720s和0.05265s，并且两组在10min、30min和40min时，差异显著(P<0.05)。The duration of Q-T segment in group Q and group Y first increased and then decreased. Compared with group Q at each time point within 30min-50min and 10min, the difference was significant (P<0.05), and the fluctuation range of each time point in group Y was not large. Statistically different, but the difference was significant between the two groups at each time point within 30min-50min (P<0.05); the duration of Q-T segment in the SX group changed greatly, and the difference was significant at each time point within 40min-50min compared with 10min (P<0.05). P<0.05); Z group and SN group continued to decline, both reached the lowest at 40min, respectively 0.16720s and 0.05265s, and the difference between the two groups was significant at 10min, 30min and 40min (P<0.05).

Q组S-T段电压在麻醉期逐渐升高，到50min时升至最高，为0.17218mV，Q组与Y组在10min、20min和60min时比较，差异显著，与SN组在30min-40min时比较差异显著；Y组S-T段电压持续升高，但升高幅度不大，各时间点与10min比较，差异不显著；Z组、SX组和SN组电压先降低，分别在20min、40min和20min时降至最低，随后升高并趋于稳定。The S-T segment voltage of group Q gradually increased during the anesthesia period, and reached the highest level at 50 minutes, which was 0.17218mV. Compared with group Y at 10 minutes, 20 minutes and 60 minutes, the difference was significant, and the difference was significantly different from that of group SN at 30 minutes to 40 minutes. Significantly; the S-T segment voltage in group Y continued to increase, but the increase was not large, and the difference was not significant at each time point compared with 10 minutes; the voltage of group Z, SX and SN decreased first, and decreased at 20 minutes, 40 minutes and 20 minutes respectively. to a minimum, then increased and stabilized.

麻醉后，Q组QRS波持续时间先短时间下降，随后缓慢升高，各时间点差异不显著；而SN组QRS波持续时间一直下降，但降低幅度不大，均在0.0044ms内波动；SX组、Z组和Y组持续时间先升高，随后降低，其中仅Z组在30min时，与其他组比较差异显著(P<0.05)，其他时间均无统计学差异。After anesthesia, the duration of the QRS wave in the Q group decreased for a short time, and then increased slowly, with no significant difference at each time point; while the duration of the QRS wave in the SN group decreased all the time, but the decrease was not large, and both fluctuated within 0.0044ms; SX Group, Z group and Y group increased first, then decreased, and only group Z had a significant difference compared with other groups at 30 minutes (P<0.05), and there was no statistical difference at other times.

3.3.5血常规监测结果3.3.5 Blood routine monitoring results

实验结果显示，如表23至表27，各组进入麻醉期后，Z组和SN组WBC在麻醉时升高过大，与Q组、SX和Y组，在部分时间点差异显著(P<0.05)。各组RBC大多呈先升高趋势，随后下降，各时间点不存在统计学差异。Z组PLT升高较大，超出貉正常生理范围。除Z组Gran数量为先下降，随后升高外；其余四组均为先升高，而随后下降趋势；而且Z组Lym数目在0min-4h内升高过多，超出貉正常生理范围。The experimental results show that, as shown in Table 23 to Table 27, after each group entered the anesthesia period, the WBC of the Z group and the SN group increased too much during anesthesia, and there were significant differences with the Q group, SX and Y groups at some time points (P< 0.05). Most of the RBC in each group showed a trend of increasing first and then decreasing, and there was no statistical difference at each time point. The increase of PLT in group Z was relatively large, exceeding the normal physiological range of raccoon dogs. Except that the number of Gran in group Z first decreased and then increased; the other four groups all increased first and then decreased; and the number of Lym in group Z increased too much within 0 min-4h, exceeding the normal physiological range of raccoon dogs.

表23 Q组血液指标监测结果 Table 23 Blood index monitoring results of group Q

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表24 Z组血液指标监测结果 Table 24 Blood index monitoring results of group Z

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表25 SX组血液指标监测结果 Table 25 SX group blood index monitoring results

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表26 SN组血液指标监测结果 Table 26 Blood index monitoring results of SN group

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表27 Y组血液指标监测结果 Table 27 Blood index monitoring results of group Y

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

3.3.6生化监测结果3.3.6 Biochemical monitoring results

实验结果显示，如表28到32，进入麻醉期后，各组ALT均有不同程度的升高，其中Q组和Z组均在24h和48h时升高较大，与各自基础值比较差异显著(P<0.05)；SN组在4h时升至最高值，与基础值比较差异显著；Y组在2h-8h内，升高较多，与其他组比较，差异显著(P<0.05)；SX组在各时间段无统计学差异。The experimental results show that, as shown in Tables 28 to 32, after entering the anesthesia period, ALT in each group increased to varying degrees, and the Q group and Z group both increased significantly at 24h and 48h, and the difference was significant compared with their respective baseline values (P<0.05); SN group rose to the highest value at 4h, which was significantly different from the base value; Y group increased more within 2h-8h, compared with other groups, the difference was significant (P<0.05); SX There was no statistical difference between the groups at each time period.

五组AST在麻醉过程中均呈先升高后降低的趋势，但都在正常范围内波动，仅SX组在4h-12h内各时间点与其他组比较，差异显著(P<0.05)，其他时间点无统计学差异。During the anesthesia process, the AST of the five groups all showed a trend of increasing first and then decreasing, but they all fluctuated within the normal range. Only the SX group had significant differences (P<0.05) compared with other groups at each time point within 4h-12h (P<0.05). The time points were not statistically different.

Q组和SN组ALP在麻醉期时，呈现一过性降低后升高的趋势，随后变化较为稳定，在各时间点差异均不显著；Z组、SX组和Y组ALP先升高，随后逐渐降低，其中仅Z组在48h和SX组在8h时与其他组比较，差异显著(P<0.05)，其他各时间点无统计学差异。During the anesthesia period, ALP in group Q and SN showed a trend of transient decrease and then increase, and then the change was relatively stable, with no significant difference at each time point; ALP in group Z, SX and Y increased first, and then Gradually decreased, of which only the Z group at 48h and the SX group at 8h were significantly different from other groups (P<0.05), and there was no statistical difference at other time points.

Q组和Z组BUN在整个麻醉过程中变化较无规律，但波动范围不大，均在正常范围内，其中Q组在12h-24h内与基础值比较，差异显著(P<0.05)；SX组、SN组和Y组BUN呈先缓慢升高，随后逐渐下降的趋势，其中SN组在8h时与基础值比较，差异显著(P<0.05)。SN组在12h-72h内各时间点与其他组比较，差异显著(P<0.05)。BUN in group Q and group Z changed irregularly during the whole anesthesia process, but the fluctuation range was not large, all within the normal range, and the difference between group Q and the baseline value within 12h-24h was significant (P<0.05); SX The BUN of the group, SN group and Y group showed a trend of increasing slowly at first, and then gradually decreasing. Compared with the baseline value at 8 hours, the BUN of the SN group was significantly different (P<0.05). The SN group was significantly different from other groups at each time point from 12h to 72h (P<0.05).

SX组Crea在0min时有一过性升高，随后缓慢下降，但在2h时下降过多，与基础值比较，差异显著(P<0.05)；其他组Crea呈先升高，随后逐渐下降的趋势。其中，Z组在1h、2h和12h时与其他各组比较，差异显著(P<0.05)，SX组在1h、4h和12h-48h内各时间点与其他组比较差异显著(P<0.05)，Y组在0min-4h内各时间点与其他组比较，差异显著(P<0.05)，其他时间点无统计学差异。Crea in SX group increased transiently at 0 min, then decreased slowly, but decreased too much at 2 h, compared with the baseline value, the difference was significant (P<0.05); Crea in other groups first increased and then gradually decreased . Among them, group Z was significantly different from other groups at 1h, 2h and 12h (P<0.05), group SX was significantly different from other groups at each time point of 1h, 4h and 12h-48h (P<0.05) , group Y compared with other groups at each time point within 0min-4h, the difference was significant (P<0.05), and there was no statistical difference at other time points.

表28 Q组肝功和肾功检测结果 Table 28 Test results of liver function and kidney function in group Q

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表29 Z组肝功和肾功检测结果 Table 29 Test results of liver function and kidney function in group Z

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表30 SX组肝功和肾功检测结果 Table 30 Test results of liver function and kidney function in SX group

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表31 SN组肝功和肾功检测结果 Table 31 Test results of liver function and kidney function in SN group

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

表32 Y组肝功和肾功检测结果 Table 32 Test results of liver function and kidney function in group Y

注：统计分析标记同表11。Note: The marks for statistical analysis are the same as those in Table 11.

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