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Mechanism of diol dehydration by a promiscuous radical‐SAM enzyme homologue of the antiviral enzyme viperin (RSAD2) - ORA

Abstract:

3´‐deoxy nucleotides are an important class of drugs because they interfere with metabolism of nucleotides and their incorporation into DNA or RNA terminates cell division and viral replication. These compounds have largely been produced via multistep chemical synthesis and an enzyme with the ability to catalyse removal of 3´‐deoxy group from different nucleotides has yet to be described. Here, using a combination of HPLC, high‐resolution mass spectrometry, and NMR spectroscopy we demonstrate...

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Publication status:

Published

Peer review status:

Peer reviewed

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Language:

English

Keywords:

Pubs id:

UUID:

uuid:06047fd8-cbe5-497d-83ca-7bb146fdbc95

Local pid:

pubs:1083236

Source identifiers:

Deposit date:

2020-01-20

Copyright holder:

WILEY‐VCH Verlag GmbH & Co KGaA, Weinheim

Copyright date:

2020

Rights statement:

© 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

Notes:

This is the accepted manuscript version of the article. The final version is available from Wiley at https://doi.org/10.1002/cbic.201900776

Licence:

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