OK, I tried with --duplicate 200 and you can see the results at https://gist.github.com/jdemeyer/f0d63be8f30dc34cc989cd11d43df248 In short, the timings with and without PEP 580 are roughly the same (which is to be expected). Interestingly, a small but significant improvement can be seen when calling *unbound* methods. The real improvement comes from supporting a new calling protocol: formerly custom classes could only implement tp_call, but now they can use FASTCALL just like built-in functions/methods. For this, there is an improvement of roughly a factor 1.2 for calls without arguments, 1.6 for calls with positional arguments and 2.8 for calls with keywords.
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