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Thu Aug 31 19:43:52 EDT 2017 · https://mail.python.org/pipermail/python-dev/2017-August/149104.html

On Fri, Sep 1, 2017 at 9:35 AM, Manciu, Catalin Gabriel
<catalin.gabriel.manciu at intel.com> wrote:
> A huge Python program with lots of PyLong inplace operations (not just
> adds, this can be applied to all PyLong inplace operations), regardless of them
> being in a loop or not, might benefit from such an optimization.

If you're writing a lot of numerical work in Python, have you tried
running your code in PyPy? At very least, it's worth adding as another
data point in your performance comparisons.

ChrisA

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[Python-Dev] Inplace operations for PyLong objects