A review on SNP and other types of molecular markers and their use in animal genetics
AbstractDuring the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.
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Author information Authors and AffiliationsLaboratoire de génétique cellulaire, Inra, chemin de Borde-Rouge, Auzeville, BP 27, 31326, Castanet-Tolosan cedex, France
Alain Vignal, Denis Milan & Magali SanCristobal
Laboratoire de génétique biochimique et de cytogénétique, Inra, domaine de Vilvert, 78352, Jouy-en-Josas cedex, France
André Eggen
Correspondence to Alain Vignal.
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About this article Cite this articleVignal, A., Milan, D., SanCristobal, M. et al. A review on SNP and other types of molecular markers and their use in animal genetics. Genet Sel Evol 34, 275 (2002). https://doi.org/10.1186/1297-9686-34-3-275
Received: 11 February 2002
Accepted: 08 March 2002
Published: 15 May 2002
DOI: https://doi.org/10.1186/1297-9686-34-3-275
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