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Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

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This work was supported in part by grants from the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” (directed by Dr. Song Li) (2018ZX09711003) of China, the National Key R&D Program (2018YFC0310600) of China, the National Natural Science Foundation of China (31771412), and Special Fund for strategic bio-resources from Chinese Academy of Sciences (ZSYS-014). We also acknowledge the National Institute for Viral Disease Control and Prevention, China CDC; Wuhan Institute of Virology, Chinese Academy of Sciences; Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College; and Wuhan Jinyintan Hospital for their efforts in research and collecting the data and genome sequencing sharing. In addition, we acknowledge GISAID (https://www.gisaid.org/) for facilitating open data sharing.

1. Contributed equally to this work

1. Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China

   Xintian Xu & Pei Hao

2. Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China

   Ping Chen, Hui Zhou & Xuan Li

3. Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China

   Jingfang Wang

4. National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China

   Jiannan Feng & Wu Zhong

5. The Joint Program in Infection and Immunity: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

   Ping Chen & Pei Hao

6. The Joint Program in Infection and Immunity: Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China

   Pei Hao

1. Xintian Xu
2. Ping Chen
3. Jingfang Wang
4. Jiannan Feng
5. Hui Zhou
6. Xuan Li
7. Wu Zhong
8. Pei Hao

Correspondence to Xuan Li, Wu Zhong or Pei Hao.

Compliance and ethics The author(s) declare that they have no conflict of interest.

Xu, X., Chen, P., Wang, J. et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci. China Life Sci. 63, 457–460 (2020). https://doi.org/10.1007/s11427-020-1637-5

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• Received: 16 January 2020

• Accepted: 20 January 2020

• Published: 21 January 2020

• Issue Date: March 2020

• DOI: https://doi.org/10.1007/s11427-020-1637-5

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