A new and efficient synthetic route to fluorescent and 14C-double-labeled silica-based nanoparticles (NPs) is described. The synthesis has been carried out using the “oil-in-water” micro-emulsion technique. Fluorescent and radioactive labeling have been achieved entrapping labeled poly(ethylene glycol) (PEG) molecules in the NPs. The produced particles have been analyzed by means of scanning electron microscopy, photon correlation spectroscopy, confocal microscopy, scintillation counting and oxidation/combustion experiments. Fluorescence quenching experiments confirm that the label is entrapped in the particles. The results presented suggest that the silica matrix does not block the β-radiations emitted from the labeled PEG molecules entrapped in the NPs.
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The financial support of the FHNW-Forschungsfond is gratefully acknowledged. The authors wish to thank M. Martin Stoeckli (Olympus, Switzerland) for the confocal microscopy experiments.
Author information Authors and AffiliationsSchool of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, 4132, Muttenz, Switzerland
Luca Geranio, Gregor Hommes, Patrick Shahgaldian, Amina Wirth-Heller, Uwe Pieles & Philippe F.-X. Corvini
Institute of Ecopreneurship, Gründenstrasse 40, 4132, Muttenz, Switzerland
Luca Geranio, Gregor Hommes & Philippe F.-X. Corvini
Institute of Chemistry and Bioanalytics, Gründenstrasse 40, 4132, Muttenz, Switzerland
Patrick Shahgaldian, Amina Wirth-Heller & Uwe Pieles
Correspondence to Patrick Shahgaldian.
About this article Cite this articleGeranio, L., Hommes, G., Shahgaldian, P. et al. Radio (14C)- and fluorescent-doubly labeled silica nanoparticles for biological and environmental toxicity assessment. Environ Chem Lett 8, 247–251 (2010). https://doi.org/10.1007/s10311-009-0213-2
Received: 22 October 2008
Accepted: 19 March 2009
Published: 15 April 2009
Issue Date: September 2010
DOI: https://doi.org/10.1007/s10311-009-0213-2
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