Children affected by attention deficit/hyperactivity disorder are often treated with methylphenidate (MPH). Two years ago, an increase in genomic damage after 3 months of MPH treatment was reported by researchers from Texas, U.S.A., raising concern about potential carcinogenic effects. In a similar investigation conducted in Wuerzburg, Germany, we did not find a comparable elevation of genomic damage. MPH is not genotoxic in standard test systems, but yielded one positive result in a rodent carcinogenicity study at the highest test dose only (60-fold above therapeutic doses). In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this article Subscribe and saveSpringer+ Basic
€34.99 /Month
Price includes VAT (Germany)
Instant access to the full article PDF.
Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. ReferencesAC Andreazza BN Frey SS Valvassori C Zanotto KM Gomes CM Comim C Cassini L Stertz LC Ribeiro J Quevedo F Kapczinski M Berk CA Goncalves (2007) ArticleTitleDNA damage in rats after treatment with methylphenidate Prog Neuropsychopharmacol Biol Psychiatry 31 IssueID6 1282–1288 Occurrence Handle17614179 Occurrence Handle10.1016/j.pnpbp.2007.05.012 Occurrence Handle1:CAS:528:DC%2BD2sXot12qu7k%3D
J Biederman SV Faraone (2005) ArticleTitleAttention-deficit hyperactivity disorder Lancet 366 237–248 Occurrence Handle16023516 Occurrence Handle10.1016/S0140-6736(05)66915-2
S Bonassi A Znaor M Ceppi C Lando WP Chang N Holland M Kirsch-Volders E Zeiger S Ban R Barale MP Bigatti C Bolognesi A Cebulska-Wasilewska E Fabianova A Fucic L Hagmar G Joksic A Martelli L Migliore E Mirkova MR Scarfi A Zijno H Norppa M Fenech (2006) ArticleTitleAn increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans Carcinogenesis 28 IssueID3 625–631 Occurrence Handle16973674 Occurrence Handle10.1093/carcin/bgl177
DP Cioca N Watanabe M Isobe (2000) ArticleTitleApoptosis of peripheral blood lymphocytes is induced by catecholamines Jpn Heart J 41 385–398 Occurrence Handle10987355 Occurrence Handle10.1536/jhj.41.385 Occurrence Handle1:CAS:528:DC%2BD3cXmvVWgtro%3D
M Cosentino E Rasini C Colombo F Marino F Blandini M Ferrari A Samuele S Lecchini G Nappi G Frigo (2004) ArticleTitleDopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect Free Radic Biol Med 36 1233–1240 Occurrence Handle15110388 Occurrence Handle10.1016/j.freeradbiomed.2004.02.065 Occurrence Handle1:CAS:528:DC%2BD2cXjsVelsLo%3D
InstitutionalAuthorNameDSM-IV-TR (2000) Diagnostic and statistical manual of mental disorders, 4th edn, text revision American Psychiatric Association Washington, DC
RA El-Zein SZ Abdel-Rahman MJ Hay MS Lopez ML Bondy DL Morris MS Legator (2005) ArticleTitleCytogenetic effects in children treated with methylphenidate Cancer Lett 230 IssueID2 284–291 Occurrence Handle16297714 Occurrence Handle10.1016/j.canlet.2005.01.003 Occurrence Handle1:CAS:528:DC%2BD2MXht1aqu77K
RA El-Zein MJ Hay MS Lopez ML Bondy DL Morris MS Legator SZ Abdel-Rahman (2006) ArticleTitleResponse to comments on ‘Cytogenetic effects in children treated with methylphenidate’ by El-Zein et al Cancer Lett 231 IssueID1 146–148 Occurrence Handle16290920 Occurrence Handle10.1016/j.canlet.2005.10.007 Occurrence Handle1:CAS:528:DC%2BD2MXhtlaitbbE
L Hagmar U Stromberg S Bonassi IL Hansteen LE Knudsen C Lindholm H Norppa (2004) ArticleTitleImpact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts Cancer Res 64 IssueID6 2258–2263 Occurrence Handle15026371 Occurrence Handle10.1158/0008-5472.CAN-03-3360 Occurrence Handle1:CAS:528:DC%2BD2cXitFCnsr0%3D
M Holtmann B Kaina F Poustka (2006) ArticleTitleMethylphenidate-induced cytogenetic alterations? [in German] Z Kinder Jugendpsychiatr Psychother 34 215–220 Occurrence Handle16771035 Occurrence Handle10.1024/1422-4917.34.3.215
M Huss (2004) Langzeiteffekte der Stimulanzientherapie M Schulte-Markwort A Warnke (Eds) Methylphenidat Thieme Stuttgart 34–43
E Junn MM Mouradian (2001) ArticleTitleApoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases J Neurochem 78 IssueID2 374–383 Occurrence Handle11461973 Occurrence Handle10.1046/j.1471-4159.2001.00425.x Occurrence Handle1:CAS:528:DC%2BD3MXlsVeitrg%3D
MJ Le Nedelec RJ Rosengren (2002) ArticleTitleMethylphenidate inhibits cytochrome P450 in the Swiss Webster mouse Hum Exp Toxicol 21 273–280 Occurrence Handle12141399 Occurrence Handle10.1191/0960327102ht245oa Occurrence Handle1:CAS:528:DC%2BD38Xmt1Gksb0%3D
P Moldeus M Nordenskjold G Bolcsfoldi A Eiche U Haglund B Lambert (1983) ArticleTitleGenetic toxicity of dopamine Mutat Res 124 IssueID1 9–24 Occurrence Handle6415476 Occurrence Handle10.1016/0165-1218(83)90181-7 Occurrence Handle1:CAS:528:DyaL2cXhtFGn
NTP (1995) Toxicology and carcinogenesis studies of methylphenidate hydrochloride (CAS no. 298-59-9) in F344/N rats and B6C3F1 mice (feed studies). Technical report 439. National Toxicology Program, Research Triangle Park, NC
RJ Preston SH Kollins JM Swanson LL Greenhill T Wigal GR Elliott B Vitiello (2005) ArticleTitleComments on ‘Cytogenetic effects in children treated with methylphenidate’ by El-Zein et al Cancer Lett 230 292–294 Occurrence Handle16019134 Occurrence Handle10.1016/j.canlet.2005.05.038 Occurrence Handle1:CAS:528:DC%2BD2MXht1aqu77L
JV Selby GD Friedman BH Fireman (1989) ArticleTitleScreening prescription drugs for possible carcinogenicity: eleven to fifteen years of follow-up Cancer Res 49 5736–5747 Occurrence Handle2571410 Occurrence Handle1:STN:280:DyaK3c%2Fgt12gsQ%3D%3D
W Suter HJ Martus A Elhajouji (2006) ArticleTitleMethylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test Mutat Res 607 153–159 Occurrence Handle16829163 Occurrence Handle1:CAS:528:DC%2BD28Xns12ru7k%3D
E Taylor M Dopfner J Sergeant P Asherson T Banaschewski J Buitelaar D Coghill M Danckaerts A Rothenberger E Sonuga-Barke HC Steinhausen A Zuddas (2004) ArticleTitleEuropean clinical guidelines for hyperkinetic disorder – first upgrade Eur Child Adol Psychiatry 13 IssueIDSuppl 1 17–30
SK Teo RH San VO Wagner R Gudi DI Stirling SD Thomas VD Khetani (2003) ArticleTitleD-Methylphenidate is non-genotoxic in in vitro and in vivo assays Mutat Res 537 67–79 Occurrence Handle12742508 Occurrence Handle1:CAS:528:DC%2BD3sXjs1Gjtrg%3D
S Walitza B Werner M Romanos A Warnke M Gerlach H Stopper (2007) ArticleTitleDoes methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environ Health Perspect 115 IssueID6 936–940 Occurrence Handle17589603 Occurrence Handle1:CAS:528:DC%2BD2sXnvFalt7w%3D Occurrence Handle10.1289/ehp.9866
Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany
H. Stopper
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
S. Walitza, A. Warnke & M. Gerlach
Correspondence to H. Stopper.
Additional informationCorrespondence: Helga Stopper, Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, 97078 Wuerzburg, Germany
About this article Cite this articleStopper, H., Walitza, S., Warnke, A. et al. Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate. J Neural Transm 115, 331–334 (2008). https://doi.org/10.1007/s00702-007-0829-y
Received: 02 August 2007
Accepted: 18 September 2007
Published: 12 November 2007
Issue Date: February 2008
DOI: https://doi.org/10.1007/s00702-007-0829-y
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4