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Chemotherapy-induced nausea and vomiting in routine practice: a European perspective

Abstract Goals of work

The aim of this study was to evaluate the occurrence of chemotherapy-induced nausea and vomiting (CINV) and its effect on patients’ ability to carry out daily life activities following moderately to highly emetogenic, first-cycle chemotherapy in routine practice in cancer centers of four different European countries.

Patients and methods

This was a prospective, cross-sectional, nonrandomized, self-assessment study in 249 patients enrolled from cancer centers in Spain, Austria, Germany, and Switzerland. The study population consisted of 78% women, with a mean age of 54. Breast, lung, and ovarian cancers made up 75% of all cancers in the study. Patients received a mean of 2.0 chemotherapy agents and 2.5 antiemetic drugs.

Main results

A total of 450 emetic episodes experienced by 243 patients was recorded over 5 days following chemotherapy, with an average of 1.8 episodes per patient (range: 0–28). A higher percentage of patients (38%) suffered from delayed compared to acute emesis (13%). Between 42% and 52% of all patients suffered from nausea (visual analogue scale ≥5 mm) on any one day, peaking at day 3. Using the Functional Living Index for Emesis (FLIE) questionnaire, 75% of patients with nausea and 50% with vomiting reported a negative impact of these conditions on performance of daily living.

Conclusions

CINV remains a significant problem in routine practice, particularly in the delayed phase posttreatment. Overall, CINV had a negative impact on patients’ daily life.

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Acknowledgements

This study represents a project of the European Oncology Nursing Society and was supported by an unrestricted project grant from Merck & Co., Inc., USA. We thank all patients who were willing to assist in this study whilst going through a difficult time. We also thank the board members of the European Oncology Nursing Society for the support of this project. We acknowledge the medical writers Ms. Helena Corte-Real and Mr. Charles Robinson, Phocus, Basel, Switzerland. We thank Dr. Steven Grunberg, Fletcher Allen Health Care, University of Vermont, USA, for his critical review of the manuscript.

Author information Authors and Affiliations

  1. Zentrum für Tumordiagnostik und Prävention (ZeTuP), Rorschacher Strasse 150, 9006 St. , Gallen, Switzerland

    Agnes Glaus, Cornelia Knipping & Rudolf Morant

  2. Department of Innere Medizin, Kantonsspital St. Gallen (KSSG), 9007, St. Gallen, Switzerland

    Christel Böhme

  3. Universitätsklinikum Heidelberg Fachweiterbildung, Im Neuenheimer Feld 105, 69120, Heidelberg, Germany

    Burkhard Lebert & Frank Beldermann

  4. LKH-Universitätsklinikum, Medizinische Universitätsklinik, Auenbruggerplatz 15, 8036, Graz, Austria

    Bernhard Glawogger

  5. Institut Catala Oncologia ICO, Av. Castelldefels s/n/km 2, 7 l’Hospitalet., 08907 , Barcelona, Spain

    Paz Fernandez Ortega

  6. Institut für mathematische Statistik und Versicherungslehre, Universität Bern, Sidlerstrasse 5, 3012, Bern, Switzerland

    André Hüsler

  7. Merck & Co., Inc., One Merck Drive, PO Box 100 (WS2E-76), Whitehouse Station, NJ 08889, USA

    Robert Deuson

Authors
  1. Agnes Glaus
  2. Cornelia Knipping
  3. Rudolf Morant
  4. Christel Böhme
  5. Burkhard Lebert
  6. Frank Beldermann
  7. Bernhard Glawogger
  8. Paz Fernandez Ortega
  9. André Hüsler
  10. Robert Deuson
Corresponding author

Correspondence to Agnes Glaus.

About this article Cite this article

Glaus, A., Knipping, C., Morant, R. et al. Chemotherapy-induced nausea and vomiting in routine practice: a European perspective. Support Care Cancer 12, 708–715 (2004). https://doi.org/10.1007/s00520-004-0662-x

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