Abbracchio MP, Burnstock G (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64:445–475
Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M (2003) Novel P2X7 receptor antagonists. Bioorg Med Chem Lett 13:4043–4046
Alexander K, Niforatos W, Bianchi B, Burgard EC, Lynch KJ, Kowaluk EA, Jarvis MF, Van Biesen T (1999) Allosteric modulation and accelerated resensitization of human P2X3 receptors by cibacron blue. J Pharmacol Exp Ther 291:1135–1142
Aschrafi A, Sadtler S, Niculescu C, Rettinger J, Schmalzing G (2004) Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. J Mol Biol 342:333–343
Banfi C, Ferrario S, De Vincenti O, Ceruti S, Fumagalli M, Mazzola A, D’Ambrosi N, Volonte C, Fratto P, Vitali E, Burnstock G, Beltrami E, Parolari A, Polvani G, Biglioli P, Tremoli E, Abbracchio MP (2005) P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death. J Mol Cell Cardiol 39:929–939
Baraldi PG, Nuñez MC, Morelli A, Falzoni S, Di Virgilio F, Romagnoli R (2003) Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J Med Chem 46:1318–1329
Barclay J, Patel S, Dorn G, Wotherspoon G, Moffatt S, Eunson L, Abdel’al S, Natt F, Hall J, Winter J, Bevan S, Wishart W, Fox A, Ganju P (2002) Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22:8139–8147
Bardoni R, Goldstein PA, Lee CJ, Gu JG, MacDermott AB (1997) ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. J Neurosci 17:5297–5304
Baricordi OR, Ferrari D, Melchiorri L, Chiozzi P, Hanau S, Chiari E, Rubini M, Di Virgilio F (1996) An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytes. Blood 87:682–690
Barrera NP, Ormond SJ, Henderson RM, Murrell-Lagnado RD, Edwardson JM (2005) Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J Biol Chem 280:10759–10765
Baxter A, Bent J, Bowers K, Braddock M, Brough S, Fagura M, Lawson M, McInally T, Mortimore M, Robertson M, Weaver R, Webborn P (2003) Hit-to-lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists. Bioorg Med Chem Lett 13:4047–4050
Bertrand PP, Bornstein JC (2002) ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. J Neurosci 22:4767–4775
Bian X, Ren J, DeVries M, Schnegelsberg B, Cockayne DA, Ford APDW, Galligan JJ (2003) Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit. J Physiol 551:309–322
Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis MF, van Biesen T (1999) Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol 376:127–138
Birder LA, Ruan HZ, Chopra B, Xiang Z, Barrick S, Buffington CA, Roppolo JR, Ford APDW, de Groat WC, Burnstock G (2004) Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287:F1084–F1091
Blanchard DK, Wei S, Duan C, Pericle F, Diaz JI, Djeu JY (1995) Role of extracellular adenosine triphosphate in the cytotoxic T-lymphocyte-mediated lysis of antigen presenting cells. Blood 85:3173–3182
Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol 63:1407–1416
Bo X, Kim M, Nori SL, Schoepfer R, Burnstock G, North RA (2003) Tissue distribution of P2X4 receptors studied with an ectodomain antibody. Cell Tissue Res 313:159–165
Bo X, Schoepfer R, Burnstock G (2000) Molecular cloning and characterization of a novel ATP P2X receptor subtype from embryonic chick skeletal muscle. J Biol Chem 275:14401–14407
Bo X, Zhang Y, Nassar M, Burnstock G, Schoepfer R (1995) A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett 375:129–133
Bobanovic LK, Royle SJ, Murrell-Lagnado RD (2002) P2X receptor trafficking in neurons is subunit specific. J Neurosci 22:4814–4824
Boue-Grabot E, Emerit MB, Toulme E, Seguela P, Garret M (2004) Cross-talk and co-trafficking between ρ1/GABA receptors and ATP-gated channels. J Biol Chem 279:6967–6975
Bradbury EJ, Burnstock G, McMahon SB (1998) The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12:256–268
Brake AJ, Wagenbach MJ, Julius D (1994) New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371:519–523
Brandle U, Spielmanns P, Osteroth R, Sim J, Surprenant A, Buell G, Ruppersberg JP, Plinkert PK, Zenner HP, Glowatzki E (1997) Desensitization of the P2X2 receptor controlled by alternative splicing. FEBS Lett 404:294–298
Brouns I, Adriaensen D, Burnstock G, Timmermans JP (2000) Intraepithelial vagal sensory nerve terminals in rat pulmonary neuroepithelial bodies express P2X3 receptors. Am J Respir Cell Mol Biol 23:52–61
Brouns I, Van Genechten J, Hayashi H, Gajda M, Gomi T, Burnstock G, Timmermans JP, Adriaensen D (2003) Dual sensory innervation of pulmonary neuroepithelial bodies. Am J Respir Cell Mol Biol 28:275–285
Brown SG, Townsend-Nicholson A, Jacobson KA, Burnstock G, King BF (2002) Heteromultimeric P2X1/2 receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther 300:673–680
Buell G, Chessell IP, Michel AD, Collo G, Salazzo M, Herren S, Gretener D, Grahames C, Kaur R, Kosco-Vilbois MH, Humphrey PPA (1998) Blockade of human P2X7 receptor function with a monoclonal antibody. Blood 92:3521–3528
Buell G, Lewis C, Collo G, North RA, Surprenant A (1996) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J 15:55–62
Bulanova E, Budagian V, Orinska Z, Hein M, Petersen F, Thon L, Adam D, Bulfone-Paus S (2005) Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J Immunol 174:3880–3890
Burgard EC, Niforatos W, Van Biesen T, Lynch KJ, Kage KL, Touma E, Kowaluk EA, Jarvis MF (2000) Competitive antagonism of recombinant P2X2/3 receptors by 2′, 3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP). Mol Pharmacol 58:1502–1510
Burgard EC, Niforatos W, Van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF (1999) P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 82:1590–1598
Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509–581
Burnstock G (1978) A basis for distinguishing two types of purinergic receptor. In: Straub RW, Bolis L (eds) Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Raven, New York, pp 107–118
Burnstock G (1999) Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J Anat 194:335–342
Burnstock G (2001) Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22:182–188
Burnstock G (2003) Purinergic receptors in the nervous system. In Schwiebert EM (ed) Current topics in membranes. Purinergic receptors and signaling, vol. 54. Academic, San Diego, pp 307–368
Burnstock G, Cocks T, Crowe R, Kasakov L (1978) Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol 63:125–138
Burnstock G, Dumsday B, Smythe A (1972) Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol 44:451–461
Burnstock G, Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433–440
Burnstock G, Knight GE (2004) Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240:31–304
Burnstock G, Lavin S (2002) Interstitial cells of Cajal and purinergic signalling. Auton Neurosci 97:68–72
Burton LD, Housley GD, Salih SG, Jarlebark L, Christie DL, Greenwood D (2000) P2X2 receptor expression by interstitial cells of Cajal in vas deferens implicated in semen emission. Auton Neurosci 84:147–161
Calvert JA, Evans RJ (2004) Heterogeneity of P2X receptors in sympathetic neurons: contribution of neuronal P2X1 receptors revealed using knockout mice. Mol Pharmacol 65:139–148
Calvert RC, Shabbir M, Thompson CS, Mikhailidis DP, Morgan RJ, Burnstock G (2004) Immunocytochemical and pharmacological characterisation of P2-purinoceptor-mediated cell growth and death in PC-3 hormone refractory prostate cancer cells. Anticancer Res 24:2853–2859
Cascio M (2004) Structure and function of the glycine receptor and related nicotinicoid receptors. J Biol Chem 279:19383–19386
Castelucci P, Robbins HL, Poole DP, Furness JB (2002) The distribution of purine P2X2 receptors in the guinea-pig enteric nervous system. Histochem Cell Biol 117:415–422
Chakfe Y, Seguin R, Antel JP, Morissette C, Malo D, Henderson D, Seguela P (2002) ADP and AMP induce interleukin-1β release from microglial cells through activation of ATP-primed P2X7 receptor channels. J Neurosci 22:3061–3069
Chen C, Parker MS, Barnes AP, Deininger P, Bobbin RP (2000) Functional expression of three P2X2 receptor splice variants from guinea pig cochlea. J Neurophysiol 83:1502–1509
Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428–431
Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CBA, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386–396
Chessell IP, Michel AD, Humphrey PPA (1998) Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124:1314–1320
Chessell IP, Simon J, Hibell AD, Michel AD, Barnard EA, Humphrey PPA (1998) Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett 439:26–30
Cheung KK, Burnstock G (2002) Localization of P2X3 receptors and coexpression with P2X2 receptors during rat embryonic neurogenesis. J Comp Neurol 443:368–382
Cheung KK, Chan WY, Burnstock G (2005) Expression of P2X purinoceptors during rat brain development and their inhibitory role on motor axon outgrowth in neural tube explant cultures. Neuroscience 133:937–945
Clyne JD, Brown TC, Hume RI (2003) Expression level dependent changes in the properties of P2X2 receptors. Neuropharmacology 44:403–412
Clyne JD, LaPointe LD, Hume RI (2002) The role of histidine residues in modulation of the rat P2X2 purinoceptor by zinc and pH. J Physiol 539:347–359
Cockayne DA, Dunn PM, Zhong Y, Rong W, Hamilton SG, Knight GE, Ruan HZ, Ma B, Yip P, Nunn P, McMahon SB, Burnstock G, Ford APDW (2005) P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567:621–639
Cockayne DA, Hamilton SG, Zhu Q-M, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford APDW (2000) Urinary bladder hyporeflexia and reduced pain-related behavior in P2X3-deficient mice. Nature 407:1011–1015
Collet C, Strube C, Csernoch L, Mallouk N, Ojeda C, Allard B, Jacquemond V (2002) Effects of extracellular ATP on freshly isolated mouse skeletal muscle cells during pre-natal and post-natal development. Pflugers Arch 443:771–778
Collo G, Neidhart S, Kawashima E, Kosco-Vilbois M, North RA, Buell G (1997) Tissue distribution of the P2X7 receptor. Neuropharmacology 36:1277–1284
Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (1996) Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495–2507
Colvin RA, Fontaine CP, Laskowski M, Thomas D (2003) Zn2+ transporters and Zn2+ homeostasis in neurons. Eur J Pharmacol 479:171–185
Cook SP, Rodland KD, McCleskey EW (1998) A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization. J Neurosci 18:9238–9244
Davies DL, Kochegarov AA, Kuo ST, Kulkarni AA, Woodward JJ, King BF, Alkana RL (2005) Ethanol differentially affects ATP-gated P2X3 and P2X4 receptor subtypes expressed in Xenopus oocytes. Neuropharmacology 49:243–253
Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM (2000) Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the γ-aminobutyric acidA receptor. J Pharmacol Exp Ther 295:1051–1060
Deuchars SA, Atkinson L, Brooke RE, Musa H, Milligan CJ, Batten TFC, Buckley NJ, Parson SH, Deuchars J (2001) Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J Neurosci 21:7143–7152
Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97:587–600
Diaz-Hernandez M, Cox JA, Migita K, Haines W, Egan TM, Voigt MM (2002) Cloning and characterization of two novel zebrafish P2X receptor subunits. Biochem Biophys Res Commun 295:849–853
Ding S, Sachs F (1999) Ion permeation and block of P2X2 purinoceptors: single channel recordings. J Membr Biol 172:215–223
Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJC, Martin P, Bevan S, Fox A, Ganju P, Wishart W, Hall J (2004) siRNA relieves chronic neuropathic pain. Nucleic Acids Res 32:e49
Drury AN, Szent-Györgyi A (1929) The physiological activity of adenine compounds with special reference to their action upon mammalian heart. J Physiol 68:213–237
Duan S, Anderson CM, Keung EC, Chen Y, Chen Y, Swanson RA (2003) P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci 23:1320–1328
Dunn PM, Blakeley AGH (1988) Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. Br J Pharmacol 93:243–245
Dunn PM, Liu M, Zhong Y, King BF, Burnstock G (2000) Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X3 and P2X2/3 receptors and between two P2X receptors in rat sensory neurones. Br J Pharmacol 130:1378–1384
Dunn PM, Zhong Y, Burnstock G (2001) P2X receptors in peripheral neurons. Prog Neurobiol 65:107–134
Ennion S, Hagan S, Evans RJ (2000) The role of positively charged amino acids in ATP recognition by human P2X1 receptors. J Biol Chem 275:29361–29367
Erhardt JA, Pillarisetti K, Toomey JR (2003) Potentiation of platelet activation through the stimulation of P2X1 receptors. J Thromb Haemost 1:2626–2635
Evans RJ, Lewis C, Buell G, Valera S, North RA, Surprenant A (1995) Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol Pharmacol 48:178–183
Evans RJ, Lewis C, Virginio C, Lundstrom K, Buell G, Surprenant A, North RA (1996) Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol 497:413-422
Falzoni S, Munerati M, Ferrari D, Spisani S, Moretti S, Di Virgilio F (1995) The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest 95:1207–1216
Faria RX, DeFarias FP, Alves LA (2005) Are second messengers crucial for opening the pore associated with P2X7 receptor? Am J Physiol Cell Physiol 288:C260-C271
Ferguson DR, Kennedy I, Burton TJ (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism? J Physiol 505:503–511
Ferrari D, Chiozzi P, Falzoni S, Dal Susino M, Melchiorri L, Baricordi OR, Di Virgilio F (1997) Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol 159:1451–1458
Finger TE, Danilova V, Barrows J, Bartel DL, Vigers AJ, Stone L, Hellekant G, Kinnamon SC (2005) ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310:1495–1499
Fisher JA, Girdler G, Khakh BS (2004) Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions. J Neurosci 24:10475–10487
Ford APDW, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol 147:S132–S143
Ford KK, Matchett M, Krause JE, Yu W (2005) The P2X3 antagonist P1, P5-di[inosine-5′] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 315:405–413
Franke H, Bringmann A, Pannicke T, Krügel U, Grosche J, Reichenbach A, Illes P (2001) P2 receptors on macroglial cells: functional implications for gliosis. Drug Dev Res 53:140–147
Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143–156
Fu XW, Nurse CA, Cutz E (2004) Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission. Biol Chem 385:275–284
Fujii K (1988) Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder. J Physiol 404:39–52
Galligan JJ (2004) Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome. Br J Pharmacol 141:1294–1302
Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stuhmer W (1997) Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol Pharmacol 51:109–118
Garcia-Guzman M, Soto F, Laube B, Stuhmer W (1996) Molecular cloning and functional expression of a novel rat heart P2X purinoceptor. FEBS Lett 388:123–127
Garcia-Guzman M, Stuhmer W, Soto F (1997) Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. Mol Brain Res 47:59–66
Gargett CE, Wiley JS (1997) The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol 120:1483–1490
Gartland A, Buckley KA, Bowler WB, Gallagher JA (2003) Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif Tissue Int 73:361–369
Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA (2003) Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice. Crit Rev Eukaryot Gene Expr 13:243–253
Gartland A, Hipskind RA, Gallagher JA, Bowler WB (2001) Expression of a P2X7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res 16:846–856
Gayle S, Burnstock G (2005) Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa. Cell Tissue Res 319:27–36
Gever JR, Padilla F, Knight GF, Dunn PM, Tran A, Mandel DA, Hegde SS, Jaime-Figueroa S, Greenhouse RJ, Lachnit WG, Burnstock G, Ford APDW (2004) In vitro and in vivo characterization of RO0437626, a novel and selective P2X1 antagonist. In: Purines 2004, p 86. 4th International symposium on nucleosides and nucleotides, Chapel Hill, NC, June 6–9, 2004
Gilchrist LS, Cain DM, Harding-Rose C, Kov AN, Wendelschafer-Crabb G, Kennedy WR, Simone DA (2005) Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Res 1044:197–205
Glass R, Townsend-Nicholson A, Burnstock G (2000) P2 receptors in the thymus: expression of P2X and P2Y receptors in adult rats, an immunohistochemical and in situ hybridisation study. Cell Tissue Res 300:295–306
Gonzalez FA, Ahmed AH, Lustig KD, Erb L, Weisman GA (1989) Permeabilization of transformed mouse fibroblasts by 3′-O-(4-benzoyl)benzoyl adenosine 5′-triphosphate and the desensitization of the process. J Cell Physiol 139:109–115
Gourine AV, Atkinson L, Deuchars J, Spyer KM (2003) Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit. J Physiol 552:197–211
Grahames CBA, Michel AD, Chessell IP, Humphrey PPA (1999) Pharmacological characterization of ATP- and LPS-induced IL-1β release in human monocytes. Br J Pharmacol 127:1915–1921
Greig AVH, James SE, McGrouther DA, Terenghi G, Burnstock G (2003) Purinergic receptor expression in the regenerating epidermis in a rat model of normal and delayed wound healing. Exp Dermatol 12:860–871
Greig AVH, Linge C, Healy V, Lim P, Clayton E, Rustin MHA, McGrouther DA, Burnstock G (2003) Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. J Invest Dermatol 121:315–327
Groschel-Stewart U, Bardini M, Robson T, Burnstock G (1999) Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia. Cell Tissue Res 296:599–605
Grubb BD, Evans RJ (1999) Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur J Neurosci 11:149–154
Grutter T, Le Novere N, Changeux JP (2004) Rational understanding of nicotinic receptors drug binding. Curr Top Med Chem 4:645–651
Gu JG, MacDermott AB (1997) Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389:749–753
Gudipaty L, Humphreys BD, Buell G, Dubyak GR (2001) Regulation of P2X7 nucleotide receptor function in human monocytes by extracellular ions and receptor density. Am J Physiol Cell Physiol 280:C943–C953
Guo LH, Trautmann K, Schluesener HJ (2005) Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain. J Neuroimmunol 163:120–127
Haines WR, Torres GE, Voigt MM, Egan TM (1999) Properties of the novel ATP-gated ionotropic receptor composed of the P2X1 and P2X5 isoforms. Mol Pharmacol 56:720–727
Hansen MA, Balcar VJ, Barden JA, Bennett MR (1998) Localisation of P2X subtypes in heart, artery and bladder. Drug Dev Res 43:5
Hansen MA, Bennett MR, Barden JA (1999) Distribution of purinergic P2X receptors in the rat heart. J Auton Nerv Syst 78:1–9
Hansen MA, Dutton JL, Balcar VJ, Barden JA, Bennett MR (1999) P2X (purinergic) receptor distributions in rat blood vessels. J Auton Nerv Syst 75:147–155
He L, Chen J, Dinger B, Stensaas L, Fidone S (2006) Effect of chronic hypoxia on purinergic synaptic transmission in rat carotid body. J Appl Phys 100:157–162
Hechler B, Lenain N, Marchese P, Vial C, Heim V, Freund M, Cazenave JP, Cattaneo M, Ruggeri ZM, Evans R, Gachet C (2003) A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med 198:661–667
Hibell AD, Kidd EJ, Chessell IP, Humphrey PPA, Michel AD (2000) Apparent species differences in the kinetic properties of P2X7 receptors. Br J Pharmacol 130:167–173
Hibell AD, Thompson KM, Xing M, Humphrey PPA, Michel AD (2001) Complexities of measuring antagonist potency at P2X7 receptor orthologs. J Pharmacol Exp Ther 296:947–957
Hoebertz A, Townsend-Nicholson A, Glass R, Burnstock G, Arnett TR (2000) Expression of P2 receptors in bone and cultured bone cells. Bone 27:503–510
Holton P (1959) The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 145:494–504
Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K (2002) Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99:11–19
Honore P, Mikusa J, Bianchi B, McDonald H, Cartmell J, Faltynek C, Jarvis MF (2002) TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain 96:99–105
Horner S, Menke K, Hildebrandt C, Kassack MU, Nickel P, Ullmann H, Mahaut-Smith MP, Lambrecht G (2005) The novel suramin analog NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. Naunyn-Schmiedebergs Arch Pharmacol 372:1–13
Housley GD, Greenwood D, Bennett T, Ryan AF (1995) Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. Biochem Biophys Res Commun 212:501–508
Housley GD, Kanjhan R, Raybould NP, Greenwood D, Salih SG, Jarlebark L, Burton LD, Setz VC, Cannell MB, Soeller C, Christie DL, Usami S, Matsubara A, Yoshie H, Ryan AF, Thorne PR (1999) Expression of the P2X2 receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission. J Neurosci 19:8377–8388
Hoyle CHV, Chapple C, Burnstock G (1989) Isolated human bladder: evidence for an adenine dinucleotide acting on P2X-purinoceptors and for purinergic transmission. Eur J Pharmacol 174:115–118
Hugel S, Schlichter R (2000) Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20:2121–2130
Humphreys BD, Virginio C, Surprenant A, Rice J, Dubyak GR (1998) Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues. Mol Pharmacol 54:22–32
Ichikawa H, Fukunaga T, Jin HW, Fujita M, Takano-Yamamoto T, Sugimoto T (2004) VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. Brain Res 1008:131–136
Inoue K, Denda M, Tozaki H, Fujishita K, Koizumi S, Inoue K (2005) Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes. J Invest Dermatol 124:756–763
Inoue K, Tsuda M, Koizumi S (2003) ATP induced three types of pain behaviors, including allodynia. Drug Dev Res 59:56–63
Inoue K, Tsuda M, Koizumi S (2004) ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. J Pharmacol Sci 94:112–114
Inoue R, Brading AF (1990) The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol 100:619–625
Inoue R, Brading AF (1991) Human, pig and guinea-pig bladder smooth muscle cell generate similar inward currents in response to purinoceptor activation. Br J Pharmacol 103:1840–1841
Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112:1895–1905
Ishikawa T, Miyagi M, Ohtori S, Aoki Y, Ozawa T, Doya H, Saito T, Moriya H, Takahashi K (2005) Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats. Eur Spine J 14:559–564
Jacobson KA, Kim YC, Wildman SS, Mohanram A, Harden TK, Boyer JL, King BF, Burnstock G (1998) A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. J Med Chem 41:2201–2206
Jaime-Figueroa S, Greenhouse R, Padilla F, Dillon MP, Gever JR, Ford APDW (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg Med Chem Lett 15:3292–3295
Jarlebark LE, Housley GD, Raybould NP, Vlajkovic S, Thorne PR (2002) ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea. Neuroreport 13:1979–1984
Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C (2002) A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA 99:17179–17184
Jarvis MF, Donnelly-Roberts DD, Honore P, Harris R, Namovic MM, Hernandez G, Zhong C, Zhu C, Gauvin DM, Chandran P, Hsieh G, Perez-Medrano A, Carroll W, Sullivan JP, Faltynek CR (2005) A-740003, a novel and selective P2X7 receptor antagonist produces dose-dependent analgesia in models of neuropathic pain. Abstract viewer/itinerary planner. Society for Neuroscience 2005, Washington, District of Columbia. Online: Program No. 514.5
Jarvis MF, Wismer CT, Schweitzer E, Yu H, Van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA (2001) Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, cibacron blue. Br J Pharmacol 132:259–269
Jarvis MJ (2003) Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets 7:513–522
Jensik PJ, Holbird D, Collard MW, Cox TC (2001) Cloning and characterization of a functional P2X receptor from larval bullfrog skin. Am J Physiol Cell Physiol 281:C954–C962
Jiang LH, Kim M, Spelta V, Bo X, Surprenant A, North RA (2003) Subunit arrangement in P2X receptors. J Neurosci 23:8903–8910
Jiang LH, MacKenzie AB, North RA, Surprenant A (2000) Brilliant blue G selectively blocks ATP-gated rat P2X7 receptors. Mol Pharmacol 58:82–88
Jiang LH, Rassendren F, MacKenzie A, Zhang YH, Surprenant A, North RA (2005) N-methyl-d-glucamine and propidium dyes utilize different permeation pathways at rat P2X7 receptors. Am J Physiol Cell Physiol 289:C1295–C1302
Jiang LH, Rassendren F, Surprenant A, North RA (2000) Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J Biol Chem 275:34190–34196
Jiang T, Yeung D, Lien CF, Gorecki DC (2005) Localized expression of specific P2X receptors in dystrophin-deficient DMD and mdx muscle. Neuromuscul Disord 15:225–236
Jin Y-H, Bailey TW, Li B, Schild JH, Andresen MC (2004) Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius. J Neurosci 24:4709–4717
Jones CA, Chessell IP, Simon J, Barnard EA, Miller KJ, Michel AD, Humphrey PPA (2000) Functional characterization of the P2X4 receptor orthologues. Br J Pharmacol 129:388–394
Jones CA, Vial C, Sellers LA, Humphrey PPA, Evans RJ, Chessell IP (2004) Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel αβ-methylene ATP-sensitive phenotype. Mol Pharmacol 65:979–985
Jorgensen NR, Henriksen Z, Sorensen OH, Eriksen EF, Civitelli R, Steinberg TH (2002) Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 277:7574–7580
Kanjhan R, Housley GD, Burton LD, Christie DL, Kippenberger A, Thorne PR, Luo L, Ryan AF (1999) Distribution of the P2X2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol 407:11–32
Kanjhan R, Housley GD, Thorne PR, Christie DL, Palmer DJ, Luo L, Ryan AF (1996) Localization of ATP-gated ion channels in cerebellum using P2x2R subunit-specific antisera. Neuroreport 7:2665–2669
Kasakov L, Burnstock G (1983) The use of the slowly degradable analog, α,β-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol 86:291–294
Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, Gabel CA, Jee WSS, Dixon SJ, Sims SM, Thompson DD (2003) Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol 17:1356–1367
Kerr DIB, Krantis A (1979) A new class of ATP antagonist. Proc Aust Physiol Pharm Soc 10:156P
Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, Voigt M, Humphrey PPA (2001) International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107–118
Khakh BS, Bao XR, Labarca C, Lester HA (1999) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nature Neurosci 2:322–330
Khakh BS, Gittermann D, Cockayne DA, Jones A (2003) ATP modulation of excitatory synapses onto interneurons. J Neurosci 23:7426–7437
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J Neurosci 19:7289–7299
Kidd EJ, Grahames CBA, Simon J, Michel AD, Barnard EA, Humphrey PPA (1995) Localization of P2X purinoceptor transcripts in the rat nervous system. Mol Pharmacol 48:569–573
Kidd EJ, Miller KJ, Sansum AJ, Humphrey PPA (1998) Evidence for P2X3 receptors in the developing rat brain. Neuroscience 87:533–539
King BF, Liu M, Pintor J, Gualix J, Miras-Portugal MT, Burnstock G (1999) Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors. Br J Pharmacol 128:981–988
King BF, Townsend-Nicholson A, Wildman SS, Thomas T, Spyer KM, Burnstock G (2000) Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. J Neurosci 20:4871–4877
King BF, Wildman SS, Ziganshina LE, Pintor J, Burnstock G (1997) Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. Br J Pharmacol 121:1445–1453
King BF, Ziganshina LE, Pintor J, Burnstock G (1996) Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH. Br J Pharmacol 117:1371–1373
King M, Housley GD, Raybould NP, Greenwood D, Salih SG (1998) Expression of ATP-gated ion channels by Reissner’s membrane epithelial cells. Neuroreport 9:2467–2474
Kirkup AJ, Booth CE, Chessell IP, Humphrey PPA, Grundy D (1999) Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat. J Physiol 520:551–563
Knight GE, Bodin P, De Groat WC, Burnstock G (2002) ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol 282:F281–F288
Knight GE, Burnstock G (2004) The effect of pregnancy and the oestrus cycle on purinergic and cholinergic responses of the rat urinary bladder. Neuropharmacology 46:1049–1056
Koshimizu T, Tomic M, Koshimizu M, Stojilkovic SS (1998) Identification of amino acid residues contributing to desensitization of the P2X2 receptor channel. J Biol Chem 273:12853–12857
Koshimizu T, Tomic M, Van Goor F, Stojilkovic SS (1998) Functional role of alternative splicing in pituitary P2X2 receptor-channel activation and desensitization. Mol Endocrinol 12:901–913
Krause RM, Buisson B, Bertrand S, Corringer PJ, Galzi JL, Changeux JP, Bertrand D (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53:283–294
Krusek J, Zemkova H (1994) Effect of ivermectin on γ-aminobutyric acid-induced chloride currents in mouse hippocampal embryonic neurones. Eur J Pharmacol 259:121–128
Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168:6436–6445
Lambrecht G, Friebe T, Grimm U, Windscheif U, Bungardt E, Hildebrandt C, Baumert HG, Spatz-Kumbel G, Mutschler E (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur J Pharmacol 217:217–219
Lambrecht G, Rettinger J, Baumert HG, Czeche S, Damer S, Ganso M, Hildebrandt C, Niebel B, Spatz-Kumbel G, Schmalzing G, Mutschler E (2000) The novel pyridoxal-5′-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur J Pharmacol 387:R19–R21
Le Feuvre R, Brough D, Rothwell N (2002) Extracellular ATP and P2X7 receptors in neurodegeneration. Eur J Pharmacol 447:261–269
Le Feuvre RA, Brough D, Touzani O, Rothwell NJ (2003) Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. J Cereb Blood Flow Metab 23:381–384
Le KT, Babinski K, Seguela P (1998) Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor. J Neurosci 18:7152–7159
Le KT, Boue-Grabot E, Archambault V, Seguela P (1999) Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits. J Biol Chem 274:15415–15419
Le KT, Paquet M, Nouel D, Babinski K, Seguela P (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett 418:195–199
Lee HY, Bradini M, Burnstock G (2000) Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol 163:2002–2007
Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A (1995) Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377:432–435
Lewis CJ, Evans RJ (2001) P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations. J Vasc Res 38:332–340
Li C, Peoples RW, Li Z, Weight FF (1993) Zn2+ potentiates excitatory action of ATP on mammalian neurons. Proc Natl Acad Sci USA 90:8264–8267
Li C, Peoples RW, Weight FF (1996) Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. Neuroreport 7:2151–2154
Li C, Peoples RW, Weight FF (1996) Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons. J Neurophysiol 76:3048–3058
Li J, Liu D, Ke HZ, Duncan RL, Turner CH (2005) The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem 280:42952–42959
Liang L, Schwiebert EM (2005) Large pore formation uniquely associated with P2X7 purinergic receptor channels. Focus on “Are second messengers crucial for opening the pore associated with P2X7 receptor?” Am J Physiol Cell Physiol 288:C240–C242
Liu M, King BF, Dunn PM, Rong W, Townsend-Nicholson A, Burnstock G (2001) Coexpression of P2X3 and P2X2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons. J Pharmacol Exp Ther 296:1043–1050
Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, Van Biesen T, Kowaluk EA, Jarvis MF (1999) Molecular and functional characterization of human P2X2 receptors. Mol Pharmacol 56:1171–1181
Ma B, Ruan HZ, Burnstock G, Dunn PM (2005) Differential expression of P2X receptors on neurons from different parasympathetic ganglia. Neuropharmacology 48:766–777
Ma B, Ruan HZ, Cockayne DA, Ford APDW, Burnstock G, Dunn PM (2004) Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies. Neuropharmacology 46:1039–1048
MacKenzie AB, Mahaut-Smith MP, Sage SO (1996) Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets. J Biol Chem 271:2879–2881
Mahaut-Smith MP, Ennion SJ, Rolf MG, Evans RJ (2000) ADP is not an agonist at P2X1 receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets. Br J Pharmacol 131:108–114
Mason HS, Bourke S, Kemp PJ (2004) Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. Mol Pharmacol 66:1525–1535
McCoy DE, Taylor AL, Kudlow BA, Karlson K, Slattery MJ, Schwiebert LM, Schwiebert EM, Stanton BA (1999) Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors. Am J Physiol Renal Physiol 277:F552–F559
McGaraughty S, Wismer CT, Zhu CZ, Mikusa J, Honore P, Chu KL, Lee CH, Faltynek CR, Jarvis MF (2003) Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br J Pharmacol 140:1381–1388
Mehta VB, Hart J, Wewers MD (2001) ATP-stimulated release of interleukin (IL)-1β and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem 276:3820–3826
Merriman GH, Ma L, Shum P, McGarry D, Volz F, Sabol JS, Gross A, Zhao Z, Rampe D, Wang L, Wirtz-Brugger F, Harris BA, Macdonald D (2005) Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists. Bioorg Med Chem Lett 15:435–438
Meyer MP, Groschel-Stewart U, Robson T, Burnstock G (1999) Expression of two ATP-gated ion channels, P2X5 and P2X6, in developing chick skeletal muscle. Dev Dyn 216:442–449
Michel AD, Chessell IP, Humphrey PPA (1999) Ionic effects on human recombinant P2X7 receptor function. Naunyn-Schmiedebergs Arch Pharmacol 359:102–109
Michel AD, Grahames CBA, Humphrey PPA (1996) Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx. Naunyn-Schmiedebergs Arch Pharmacol 354:562–571
Michel AD, Kaur R, Chessell IP, Humphrey PPA (2000) Antagonist effects on human P2X7 receptor-mediated cellular accumulation of YO-PRO-1. Br J Pharmacol 130:513–520
Miller KJ, Michel AD, Chessell IP, Humphrey PPA (1998) Cibacron blue allosterically modulates the rat P2X4 receptor. Neuropharmacology 37:1579–1586
Mio K, Kubo Y, Ogura T, Yamamoto T, Sato C (2005) Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain. Biochem Biophys Res Commun 337:998–1005
Mok MHS, Knight GE, Andrews PLR, Hoyle CHV, Burnstock G (2000) The effects of cyclophosphamide on neurotransmission in the urinary bladder of Suncus murinus, the house musk shrew. J Auton Nerv Syst 80:130–136
Mulryan K, Gitterman DP, Lewis CJ, Vial C, Leckie BJ, Cobb AL, Brown JE, Conley EC, Buell G, Pritchard CA, Evans RJ (2000) Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Nature 403:86–89
Murgia M, Hanau S, Pizzo P, Rippa M, Di Virgilio F (1993) Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem 268:8199–8203
Naemsch LN, Weidema AF, Sims SM, Underhill TM, Dixon SJ (1999) P2X4 purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts. J Cell Sci 112:4425–4435
Naemsch LN, Dixon SJ, Sims SM (2001) Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts. J Biol Chem 276:39107–39114
Nagaya N, Tittle RK, Saar N, Dellal SS, Hume RI (2005) An intersubunit zinc binding site in rat P2X2 receptors. J Biol Chem 280:25982–25993
Nakatsuka T, Gu JG (2001) ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21:6522–6531
Nakatsuka T, Tsuzuki K, Ling JX, Sonobe H, Gu JG (2003) Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89:3243–3252
Nakazawa K, Ohno Y (1997) Effects of neuroamines and divalent cations on cloned and mutated ATP-gated channels. Eur J Pharmacol 325:101–108
Neelands TR, Burgard EC, Uchic ME, McDonald HA, Niforatos W, Faltynek CR, Lynch KJ, Jarvis MF (2003) 2′, 3′-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor. Br J Pharmacol 140:202–210
Newbolt A, Stoop R, Virginio C, Surprenant A, North RA, Buell G, Rassendren F (1998) Membrane topology of an ATP-gated ion channel (P2X receptor). J Biol Chem 273:15177–15182
Nicke A, Bäumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschler E, Schmalzing G (1998) P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J 17:3016–3028
Nicke A, Kerschensteiner D, Soto F (2005) Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits. J Neurochem 92:925–933
Norenberg W, Illes P (2000) Neuronal P2X receptors: localisation and functional properties. Naunyn-Schmiedebergs Arch Pharmacol 362:324–339
Nori S, Fumagalli L, Bo X, Bogdanov Y, Burnstock G (1998) Coexpression of mRNAs for P2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situ hybridization and RT-PCR study. J Vasc Res 35:179–185
North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013–1067
O’Connor SE, Wood BE, Leff P (1990) Characterization of P2X-receptors in rabbit isolated ear artery. Br J Pharmacol 101:640–644
Ohta T, Kubota A, Murakami M, Otsuguro K, Ito S (2005) P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am J Physiol Gastrointest Liver Physiol 289:G935–G948
Oury C, Kuijpers MJE, Toth-Zsamboki E, Bonnefoy A, Danloy S, Vreys I, Feijge MAH, De Vos R, Vermylen J, Heemskerk JWM, Hoylaerts MF (2003) Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype. Blood 101:3969–3976
Palea S, Pietra C, Trist DG, Artibani W, Calpista A, Corsi M (1995) Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder. Br J Pharmacol 114:35–40
Pandita RK, Andersson K-E (2002) Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats. J Urol 168:1230–1234
Pankratov Y, Castro E, Miras-Portugal MT, Krishtal O (1998) A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. Eur J Neurosci 10:3898–3902
Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R (2003) P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer’s disease. J Biol Chem 278:13309–13317
Perregaux DG, McNiff P, Laliberte R, Conklyn M, Gabel CA (2000) ATP acts as an agonist to promote stimulus-induced secretion of IL-1β and IL-18 in human blood. J Immunol 165:4615–4623
Pintor J, King BF, Miras-Portugal MT, Burnstock G (1996) Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors. Br J Pharmacol 119:1006–1012
Poole DP, Castelucci P, Robbins HL, Chiocchetti R, Furness JB (2002) The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci 101:39–47
Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, Nurse CA (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol 537:667–677
Pratt EB, Brink TS, Bergson P, Voigt MM, Cook SP (2005) Use-dependent inhibition of P2X3 receptors by nanomolar agonist. J Neurosci 25:7359–7365
Priel A, Silberberg SD (2004) Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol 123:281–293
Radford KM, Virginio C, Surprenant A, North RA, Kawashima E (1997) Baculovirus expression provides direct evidence for heteromeric assembly of P2X2 and P2X3 receptors. J Neurosci 17:6529–6533
Rae MG, Rowan EG, Kennedy C (1998) Pharmacological properties of P2X3-receptors present in neurones of the rat dorsal root ganglia. Br J Pharmacol 124:176–180
Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413–492
Rampe D, Wang L, Ringheim GE (2004) P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia. J Neuroimmunol 147:56–61
Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A (1997) The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem 272:5482–5486
Ren J, Bian X, DeVries M, Schnegelsberg B, Cockayne DA, Ford APDW, Galligan JJ (2003) P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol 552:809–821
Rettinger J, Braun K, Hochmann H, Kassack MU, Ullmann H, Nickel P, Schmalzing G, Lambrecht G (2005) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analog NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology 48:461–468
Rettinger J, Schmalzing G (2004) Desensitization masks nanomolar potency of ATP for the P2X1 receptor. J Biol Chem 279:6426–6433
Rettinger J, Schmalzing G, Damer S, Muller G, Nickel P, Lambrecht G (2000) The suramin analog NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39:2044–2053
Roberts JA, Evans RJ (2004) ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists. J Biol Chem 279:9043–9055
Robertson SJ, Rae MG, Rowan EG, Kennedy C (1996) Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. Br J Pharmacol 118:951–956
Rolf MG, Brearley CA, Mahaut-Smith MP (2001) Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP. Thromb Haemost 85:303–308
Rong W, Burnstock G (2004) Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig. Neuropharmacology 47:1093–1101
Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford APDW, Spyer KM, Burnstock G (2003) Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 23:11315–11321
Rong W, Spyer KM, Burnstock G (2002) Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol 541:591–600
Rubio ME, Soto F (2001) Distinct localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci 21:641–653
Ruppelt A, Ma W, Borchardt K, Silberberg SD, Soto F (2001) Genomic structure, developmental distribution and functional properties of the chicken P2X5 receptor. J Neurochem 77:1256–1265
Ryten M, Dunn PM, Neary JT, Burnstock G (2002) ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells. J Cell Biol 158:345–355
Ryten M, Hoebertz A, Burnstock G (2001) Sequential expression of three receptor subtypes for extracellular ATP in developing rat skeletal muscle. Dev Dyn 221:331–341
Satchell DG, Maguire MH (1975) Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli. J Pharmacol Exp Ther 195:540–548
Scheibler P, Pesic M, Franke H, Reinhardt R, Wirkner K, Illes P, Norenberg W (2004) P2X2 and P2Y1 immunofluorescence in rat neostriatal medium-spiny projection neurones and cholinergic interneurones is not linked to respective purinergic receptor function. Br J Pharmacol 143:119–131
Schwab JM, Guo L, Schluesener HJ (2005) Spinal cord injury induces early and persistent lesional P2X4 receptor expression. J Neuroimmunol 163:185–189
Seguela P, Haghighi A, Soghomonian JJ, Cooper E (1996) A novel neuronal P2X ATP receptor ion channel with widespread distribution in the brain. J Neurosci 16:448–455
Sigel E (2002) Mapping of the benzodiazepine recognition site on GABAA receptors. Curr Top Med Chem 2:833–839
Sim JA, Young MT, Sung HY, North RA, Surprenant A (2004) Reanalysis of P2X7 receptor expression in rodent brain. J Neurosci 24:6307–6314
Simon J, Kidd EJ, Smith FM, Chessell IP, Murrell-Lagnado R, Humphrey PPA, Barnard EA (1997) Localization and functional expression of splice variants of the P2X2 receptor. Mol Pharmacol 52:237–248
Skaper SD, Facci L, Culbert A, Chessell I, Davis JB, Richardson JC (2005) P2X7 receptors on microglial cells mediate toxicity to cortical neurons in vitro. Abstract viewer/itinerary planner. Society for Neuroscience 2005, Washington, District of Columbia.Online:Program No. 937.7
Sluyter R, Barden JA, Wiley JS (2001) Detection of P2X purinergic receptors on human B lymphocytes. Cell Tissue Res 304:231–236
Smith FM, Humphrey PPA, Murrell-Lagnado RD (1999) Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization. J Physiol 520:91–99
Solini A, Chiozzi P, Morelli A, Fellin R, Virgilio FD (1999) Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release. J Cell Sci 112:297–305
Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA (2001) Altered cytokine production in mice lacking P2X7 receptors. J Biol Chem 276:125–132
Soto F, Garcia-Guzman M, Gomez-Hernandez JM, Hollmann M, Karschin C, Stuhmer W (1996) P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci USA 93:3684–3688
Soto F, Lambrecht G, Nickel P, Stuehmer W, Busch AE (1999) Antagonistic properties of the suramin analog NF023 at heterologously expressed P2X receptors. Neuropharmacology 38:141–149
Souslova V, Cesare P, Ding Y, Akopian AN, Stanfa L, Suzuki R, Carpenter K, Dickenson A, Boyce S, Hill R, Nebenius-Oosthuizen D, Smith AJH, Kidd EJ, Wood JN (2000) Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature 407:1015–1017
Spehr J, Spehr M, Hatt H, Wetzel CH (2004) Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons. Eur J Neurosci 19:2497–2510
Spelta V, Jiang LH, Surprenant A, North RA (2002) Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. Br J Pharmacol 135:1524–1530
Stoop R, Surprenant A, North RA (1997) Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. J Neurophysiol 78:1837–1840
Studeny S, Torabi A, Vizzard MA (2005) P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord. Am J Physiol Regul Integr Comp Physiol 289:R1155–R1168
Sugiyama T, Kawamura H, Yamanishi S, Kobayashi M, Katsumura K, Puro DG (2005) Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels. Am J Physiol Cell Physiol 288:C568–C576
Sun Y, Chai TC (2002) Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int 90:381–385
Surprenant A, Rassendren F, Kawashima E, North RA, Buell G (1996) The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272:735–738
Surprenant A, Schneider DA, Wilson HL, Galligan JJ, North RA (2000) Functional properties of heteromeric P2X1/5 receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles. J Auton Nerv Syst 81:249–263
Tenneti L, Gibbons SJ, Talamo BR (1998) Expression and trans-synaptic regulation of P2X4 and P2Z receptors for extracellular ATP in parotid acinar cells. Effects of parasympathetic denervation. J Biol Chem 273:26799–26808
Theobald RJ Jr (1996) The effect of NG-monomethyl-l-arginine on bladder function. Eur J Pharmacol 311:73–78
Thomas S, Virginio C, North RA, Surprenant A (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. J Physiol 509:411–417
Torres GE, Egan TM, Voigt MM (1998) Topological analysis of the ATP-gated ionotropic [correction of ionotrophic] P2X2 receptor subunit. FEBS Lett 425:19–23
Torres GE, Egan TM, Voigt MM (1999) Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. J Biol Chem 274:6653–6659
Torres GE, Haines WR, Egan TM, Voigt MM (1998) Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP- gated ion channel. Mol Pharmacol 54:989–993
Townsend-Nicholson A, King BF, Wildman SS, Burnstock G (1999) Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors. Mol Brain Res 64:246–254
Trezise DJ, Michel AD, Grahames CBA, Khakh BS, Surprenant A, Humphrey PPA (1995) The selective P2X purinoceptor agonist, β,γ-methylene-l-adenosine 5′-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors. Naunyn-Schmiedebergs Arch Pharmacol 351:603–609
Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424:778–783
Tsuda M, Ueno S, Inoue K (1999) Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. Br J Pharmacol 128:1497–1504
Tsuda M, Ueno S, Inoue K (1999) In vivo pathway of thermal hyperalgesia by intrathecal administration of α,β-methylene ATP in mouse spinal cord: Involvement of the glutamate-NMDA receptor system. Br J Pharmacol 127:449–456
Ueno S, Moriyama T, Honda K, Kamiya H, Sakurada T, Katsuragi T (2003) Involvement of P2X2 and P2X3 receptors in neuropathic pain in a mouse model of chronic constriction injury. Drug Dev Res 59:104–111
Urbanek E, Nickel P, Schlicker E (1990) Antagonistic properties of four suramin-related compounds at vascular purine P2X receptors in the pithed rat. Eur J Pharmacol 175:207–210
Valera S, Hussy N, Evans RJ, Adami N, North RA, Surprenant A, Buell G (1994) A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature 371:516–519
Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (1995) Characterization and chromosomal localization of a human P2X receptor from the urinary bladder. Recept Channels 3:283–289
Van Nassauw L, Brouns I, Adriaensen D, Burnstock G, Timmermans JP (2002) Neurochemical identification of enteric neurons expressing P2X3 receptors in the guinea-pig ileum. Histochem Cell Biol 118:193–203
Vial C, Evans RJ (2000) P2X receptor expression in mouse urinary bladder and the requirement of P2X1 receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle. Br J Pharmacol 131:1489–1495
Vial C, Evans RJ (2002) P2X1 receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries. Mol Pharmacol 62:1438–1445
Vial C, Roberts JA, Evans RJ (2004) Molecular properties of ATP-gated P2X receptor ion channels. Trends Pharmacol Sci 25:487–493
Virginio C, Church D, North RA, Surprenant A (1997) Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor. Neuropharmacology 36:1285–1294
Virginio C, MacKenzie A, Rassendren FA, North RA, Surprenant A (1999) Pore dilation of neuronal P2X receptor channels. Nature Neurosci 2:315–321
Virginio C, North RA, Surprenant A (1998) Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones. J Physiol 510:27–35
Virginio C, Robertson G, Surprenant A, North RA (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol 53:969–973
Vlaskovska M, Kasakov L, Rong W, Bodin P, Bardini M, Cockayne DA, Ford APDW, Burnstock G (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 21:5670–5677
von Kügelgen I, Krumme B, Schaible U, Schollmeyer PJ, Rump LC (1995) Vasoconstrictor responses to the P2x-purinoceptor agonist β,γ-methylene-l-ATP in human cutaneous and renal blood vessels. Br J Pharmacol 116:1932–1936
Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, Elde R (1996) Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci USA 93:8063–8067
Vulchanova L, Riedl MS, Shuster SJ, Buell G, Surprenant A, North RA, Elde R (1997) Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36:1229–1242
Vulchanova L, Riedl MS, Shuster SJ, Stone LS, Hargreaves KM, Buell G, Surprenant A, North RA, Elde R (1998) P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10:3470–3478
Wang CZ, Namba N, Gonoi T, Inagaki N, Seino S (1996) Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Biochem Biophys Res Commun 220:196–202
Wang ECY, Lee JM, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, Cockayne DA, Birder LA, Apodaca G (2005) ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest 115:2412–2422
Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 10:821–827
Watkins LR, Maier SF (2003) Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov 2:973–985
Watters JJ, Sommer JA, Fisette PL, Pfeiffer AZ, Aga M, Prabhu U, Guerra AN, Denlinger LC, Bertics PJ (2001) P2X7 nucleotide receptor: modulation of LPS-induced macrophage signaling and mediator production. Drug Dev Res 53:91–104
Wildman SS, Brown SG, King BF, Burnstock G (1999) Selectivity of diadenosine polyphosphates for rat P2X receptor subunits. Eur J Pharmacol 367:119–123
Wildman SS, Brown SG, Rahman M, Noel CA, Churchill L, Burnstock G, Unwin RJ, King BF (2002) Sensitization by extracellular Ca2+ of rat P2X5 receptor and its pharmacological properties compared with rat P2X1. Mol Pharmacol 62:957–966
Wildman SS, King BF, Burnstock G (1998) Zn2+ modulation of ATP-responses at recombinant P2X2 receptors and its dependence on extracellular pH. Br J Pharmacol 123:1214–1220
Wildman SS, King BF, Burnstock G (1999) Modulatory activity of extracellular H+ and Zn2+ on ATP-responses at rP2X1 and rP2X3 receptors. Br J Pharmacol 128:486–492
Wiley JS, Chen JR, Snook MB, Jamieson GP (1994) The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP. Br J Pharmacol 112:946–950
Wong AY, Burnstock G, Gibb AJ (2000) Single channel properties of P2X ATP receptors in outside-out patches from rat hippocampal granule cells. J Physiol 527:529–547
Worthington RA, Dutton JL, Poronnik P, Bennett MR, Barden JA (1999) Localisation of P2X receptors in human salivary gland epithelial cells and human embryonic kidney cells by sodium dodecyl sulfate-polyacrylamide gel electrophoresis/Western blotting and immunofluorescence. Electrophoresis 20:2065–2070
Wu G, Whiteside GT, Lee G, Nolan S, Niosi M, Pearson MS, Ilyin VI (2004) A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol 504:45–53
Wynn G, Ma B, Ruan HZ, Burnstock G (2004) Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol 287:G647–G657
Wynn G, Rong W, Xiang Z, Burnstock G (2003) Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology 125:1398–1409
Xiang Z, Bo X, Burnstock G (1998) Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia. Neurosci Lett 256:105–108
Xiang Z, Burnstock G (2005) Changes in expression of P2X purinoceptors in rat cerebellum during postnatal development. Dev Brain Res 156:147–157
Xiong K, Hu XQ, Stewart RR, Weight FF, Li C (2005) The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241. Br J Pharmacol 145:576–586
Yiangou Y, Facer P, Baecker PA, Ford APDW, Knowles CH, Chan CL, Williams NS, Anand P (2001) ATP-gated ion channel P2X3 is increased in human inflammatory bowel disease. Neurogastroenterol Motil 13:365–369
Yiangou Y, Facer P, Ford A, Brady C, Wiseman O, Fowler CJ, Anand P (2001) Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int 87:774–779
Zhang M, Zhong H, Vollmer C, Nurse CA (2000) Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol 525:143–158
Zhong Y, Dunn PM, Burnstock G (2000) Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors. J Physiol 523:391–402
Zhong Y, Dunn PM, Burnstock G (2000) Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons. Neuropharmacology 39:172–180
Zhong Y, Dunn PM, Burnstock G (2001) Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. Br J Pharmacol 132:221–233
Zhong Y, Dunn PM, Xiang Z, Bo X, Burnstock G (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br J Pharmacol 125:771–781
Zhou X, Galligan JJ (1996) P2X purinoceptors in cultured myenteric neurons of guinea-pig small intestine. J Physiol 496:719–729
Ziyal R, Ziganshin AU, Nickel P, Ardanuy U, Mutschler E, Lambrecht G, Burnstock G (1997) Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery. Br J Pharmacol 120:954–960
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