Alfonso A, Grundahl K, Duerr JS, Han H-P, Rand JB (1993) The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter. Science 261:617–619

CAS  PubMed  Google Scholar 

Balan IS, Ugrumov MV, Calas A, Mailly P, Kreiger M, Thibault J (2000) Tyrosine hydroxylase-expressing and/or aromaticl-amino acid decarboxylase-expressing neurons in the mediobasal hypothalamus of perinatal rats: differentiation and sexual dimorphism. J Comp Neurol 425:167–176

Article  CAS  PubMed  Google Scholar 

Bruce G, Wainer BH, Hersh LB (1985) Immunoaffinity purification of human choline acetyltransferase: comparison of the brain and placental enzymes. J Neurochem 45:611–620

CAS  PubMed  Google Scholar 

Duerr JS, Frisby DL, Gaskin J, Duke A, Asermely K, Huddleston D, Eiden LE, Rand JB (1999) The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. J Neurosci 19:72–84

CAS  PubMed  Google Scholar 

Efange SMN (2000) In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter. FASEB J 14:2401–2413

Article  CAS  PubMed  Google Scholar 

Eiden LE (1998) The cholinergic gene locus. J Neurochem 70:2227–2240

CAS  PubMed  Google Scholar 

Eiden LE (2000) The vesicular neurotransmitter transporters: current perspectives and future prospects. FASEB J 14:2396–2400

Article  CAS  PubMed  Google Scholar 

Eiden LE, Schütz B, Anlauf M, Depboylu C, Schäfer MK-H, Weihe E (2002) In: T. Nagatsu, Nabeshima T, McCarty R, Goldstein DS (eds) Catecholamine research: from molecular insights to clinical medicine. Kluwer, New York, pp 23–33

Engel AG, Ohno K (2001) In: Pourmand R, Harati Y (eds) Neuromuscular disorders. Williams and Wilkins, Philadelphia, pp 203–215

Erickson JD, Eiden LE (1993) Functional identification and molecular cloning of a human brain vesicle monoamine transporter. J Neurochem 61:2314–2317

CAS  PubMed  Google Scholar 

Erickson JD, Eiden LE, Hoffman B (1992) Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Proc Natl Acad Sci USA 89:10993–10997

CAS  PubMed  Google Scholar 

Erickson JD, Varoqui H (2000) Molecular analysis of vesicular amine transporter function and targeting to secretory organelles. FASEB J 14:2450–2458

Article  CAS  PubMed  Google Scholar 

Erickson JD, Varoqui H, Schäfer M, Diebler M-F, Weihe E, Modi W, Rand J, Eiden LE, Bonner TI, Usdin T (1994) Functional characterization of the mammalian vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus. J Biol Chem 269:21929–21932

CAS  PubMed  Google Scholar 

Erickson JD, Eiden LE, Schäfer MK-H, Weihe E (1995) Reserpine- and tetrabenazine-sensitive transport of³H-histamine by the neuronal isoform of the vesicular monoamine transporter. J Mol Neurosci 6:277–287

CAS  PubMed  Google Scholar 

Erickson JD, Schäfer MK-H, Bonner TI, Eiden LE, Weihe E (1996) Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci USA 93:5166–5171

CAS  PubMed  Google Scholar 

Fon EA, Pothos EN, Sun B-C, Killeen N, Sulzer D, Edwards RH (1997) Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron 19:1271–1283

CAS  PubMed  Google Scholar 

Griffith JK, Baker ME, Rouch DA, Page MG, Skurray RA, Paulsen IT, Chater KF, Baldwin SA, Henderson PJ (1992) Membrane transport proteins: implications of sequence comparisons. Curr Opin Cell Biol 4:684–695

CAS  PubMed  Google Scholar 

Gutman N, Steiner-Mordoch S, Schuldiner S (2003) An amino acid cluster around the essential Glu-14 is part of the substrate- and proton-binding domain of EmrE, a multidrug transporter from Escherichia coli. J Biol Chem 278:16082–16087

Article  CAS  PubMed  Google Scholar 

Howell M, Shirvan A, Stern-Bach Y, Steiner-Mordoch S, Strasser JE, Dean GE, Schuldiner S (1994) Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules. FEBS Lett 338:16–22

Article  CAS  PubMed  Google Scholar 

Kim M-H, Lu M, Lim E-J, Chai Y-G, Hersh LB (1999) Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter. J Biol Chem 274:673–680

Article  CAS  PubMed  Google Scholar 

Lebrand C, Cases O, Wehrlé R, Blakely RD, Edwards RH, Gaspar P (1998) Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol. 401:506–524

Google Scholar 

Liu Y, Krantz DE, Waites C, Edwards RH (1999) Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission. Trends Cell Biol 9:356–363

Article  CAS  PubMed  Google Scholar 

Liu Y, Roghani A, Edwards RH (1992) Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 89:9074–9078

CAS  PubMed  Google Scholar 

Liu Y, Peter D, Roghani A, Schuldiner S, Prive GG, Eisenberg D, Brecha N, Edwards RH (1992) A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell 70:539–551

CAS  PubMed  Google Scholar 

Merickel A, Edwards RH (1995) Transport of histamine by vesicular monoamine transporter-2. Neuropharmacology 34:1543–1547

Article  CAS  PubMed  Google Scholar 

Merickel A, Rosandich P, Peter D, Edwards RH (1995) Identification of residues involved in substrate recognition by a vesicular monoamine transporter. J Biol Chem 270:25798–25804

Article  CAS  PubMed  Google Scholar 

Merickel A, Kaback HR, Edwards RH (1997) Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition. J Biol Chem 272:5403–5408

Article  CAS  PubMed  Google Scholar 

Ninio S, Schuldiner S (2003) Characterization of an archaeal multidrug transporter with a unique amino acid composition. J Biol Chem 278:12000–12005

Article  CAS  PubMed  Google Scholar 

Parsons SM (2000) Transport mechanisms in acetylcholine and monoamine storage. FASEB J 14:2423–2434

Article  CAS  PubMed  Google Scholar 

Parsons SM, Prior C, Marshall IG (1993) Acetylcholine transport, storage, and release. Int Rev Neurobiol 35:279–390

CAS  PubMed  Google Scholar 

Paulsen IT, Skurray RA (1993) Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes—an analysis. Gene 124:1–11

CAS  PubMed  Google Scholar 

Peter D, Liu Y, Sternini C, de Giorgio R, Brecha N, Edwards RH (1995) Differential expression of two vesicular monoamine transporters. J Neurosci 15:6179–6188

CAS  PubMed  Google Scholar 

Rand JB, Duerr JS, Frisby DL (2000) Neurogenetics of vesicular transporters in C. elegans. FASEB J 14:2414–2422

Article  CAS  PubMed  Google Scholar 

Rost B (1996) PHD: predicting one-dimensional protein structure by profile based neural networks. Methods Enzymol 266:525–539

CAS  PubMed  Google Scholar 

Rost B, Fariselli P, Casadio R (1996) Topology prediction for helical transmembrane proteins at 86% accuracy. Protein Sci 7:1704–1718

Google Scholar 

Schuldiner S, Shirvan A, Stern-Bach Y, Steiner-Mordoch S, Yelin R, Laskar O (1994) From bacterial antibiotic resistance to neurotransmitter uptake. A common theme of cell survival. Ann NY Acad Sci 733:174–184

CAS  PubMed  Google Scholar 

Schuldiner S, Shirvan A, Linial M (1995) Vesicular neurotransmitter transporters: from bacteria to humans. Physiol Rev 75:369–392

CAS  PubMed  Google Scholar 

Schütz B, Schäfer MK-H, Eiden LE, Weihe E (1998) Vesicular amine transporter expression and isoform selection in developing brain, peripheral nervous system and gut. Dev Brain Res 106:181–204

Article  Google Scholar 

Steiner-Mordoch S, Shirvan A, Schuldiner S (1996) Modification of the pH profile and tetrabenazine sensitivity of rat VMAT1 by replacement of aspartate 404 with glutamate. J Biol Chem 271:13048–13054

Article  CAS  PubMed  Google Scholar 

Takahashi N, Miner LL, Sora I, Ujike H, Revay RS, Kostic V, Jackson-Lewis V, Przedborski S, Uhl GR (1997) VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc Natl Acad Sci USA 94:9938–9943

CAS  PubMed  Google Scholar 

Thiriot DS, Sievert MK, Ruoho AE (2002) Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond. Biochemistry 41:6346–6353

Article  CAS  PubMed  Google Scholar 

Uhl GR, Li S, Takahashi N, Itokawa K, Lin Z, Hazama M, Sora I (2000) The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J 14:2459–2476

Article  CAS  PubMed  Google Scholar 

Wang Y-M, Gainetdinov RR, Fumagalli F, Xu F, Jones SR, Bock CB, Miller GW, Wightman RM, Caron MG (1997) Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19:1285–1296

CAS  Google Scholar 

Weihe E, Eiden LE (2000) Chemical neuroanatomy of the vesicular amine transporters. FASEB J 14:2435–2449

Article  CAS  PubMed  Google Scholar 

Weihe E, Schäfer MK-H, Erickson JD, Eiden LE (1994) Localization of vesicular monoamine transporter isoforms (VMAT1 and VMAT2) to endocrine cells and neurons in rat. J Mol Neurosci 5:149–164

CAS  PubMed  Google Scholar 

Weihe E, Anlauf M, Schäfer M-KH, Hartschuh W, Eiden LE (1998) VMAT2 is the transporter mediating sequestration of monoamines in rat and human platelets, mast cells, and cutaneous dendritic cells (abstract). Soc Neurosci Abstr Nov 7–12: No. 301.1