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Correlation between triplet repeat expansion and computed tomography measures of caudate nuclei atrophy in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant, progressive disorder characterized by choreic movements, cognitive decline, and psychiatric manifestations. Eleven patients with HD were retrospectively selected from a larger group of 42 patients based on the similar, early onset of the disease (between 21 and 30 years) and the same duration of HD at the moment of computed tomography (CT) examination (5 years). A significant correlation between the number of CAG trinucleotides and the bicaudate index or the frontal horn index, two indices of caudate atrophy, was found in this group of patients. Our results, although in a small number of patients, suggest that the striatal degeneration, assessed by CT measures, is primarily regulated by the size of expanded CAG repeats.

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1. Faculty of Biology, University of Belgrade, Ul. Dr Subotica 6, YU-11000 Belgrade, Yugoslavia, , , , , , YU

   Biljana Culjkovic, Oliver Stojkovic & Stanka Romac

2. Institute of Neurology CCS, Belgrade, Ul. Dr Subotica 6, YU-11000 Belgrade, Yugoslavia e-mail: kostic@imi.bg.ac.yu, Tel.: +381-11-685554, Fax: 381-11-684577, , , , , , YU

   Nikola Vojvodic, Marina Svetel & V. Kostic

3. Institute of Biochemistry, School of Medicine, Ul. Dr Subotica 6, YU-11000 Belgrade, Yugoslavia, , , , , , YU

   Ljubisa Rakic

1. Biljana Culjkovic
2. Oliver Stojkovic
3. Nikola Vojvodic
4. Marina Svetel
5. Ljubisa Rakic
6. Stanka Romac
7. V. Kostic

Received: 6 November 1998 Received in revised form: 10 May 1999 Accepted: 19 June 1999

Culjkovic, B., Stojkovic, O., Vojvodic, N. et al. Correlation between triplet repeat expansion and computed tomography measures of caudate nuclei atrophy in Huntington’s disease. J Neurol 246, 1090–1093 (1999). https://doi.org/10.1007/s004150050518

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• Issue Date: November 1999

• DOI: https://doi.org/10.1007/s004150050518

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