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Expression of IL-18 in psoriasis
Abstract Interleukin-18 (IL-18) is a novel cytokine that plays an important role in the T-helper 1 (Th1) response, primarily via its ability to induce IFN-γ production in T cells and NK cells. Human keratinocytes produce IL-18, as do monocytes and macrophages, which are the two major sources of this molecule. It is thought that IL-18 derived from keratinocytes might be involved in the cutaneous Th1-type immune response. In the present study, we investigated the expression of IL-18 in psoriatic lesional skin and attempted to determine whether immunoreactive IL-18 in crude extracts of psoriatic scales is processed to the mature, active form. Immunohistochemical and RT-PCR analysis showed that the expression of IL-18 was increased in psoriatic lesional skin relative to that in normal skin. Western blotting and an ELISA for IL-18 in combination demonstrated that the immunoreactive IL-18 in extracts of psoriatic scales contained the mature form of IL-18, but most of the IL-18 was pro-IL-18. No bioactivity of IL-18 or IFN-γ inducibility in human PBMC could be detected in psoriatic scales. Taken together, these findings indicate that keratinocyte-derived IL-18 participates in the development of the Th1 response in psoriatic lesions, and that its bioactivity appears to be tightly regulated in cutaneous inflammation.
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Department of Dermatology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228-8555, Japan, , , , , , JP
Yukinori Ohta, Yuko Hamada & Kensei Katsuoka
Authors
- Yukinori Ohta
- Yuko Hamada
- Kensei Katsuoka
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Received: 18 October 2000 / Revised: 3 February 2001 / Accepted: 27 April 2001
About this article Cite this article
Ohta, Y., Hamada, Y. & Katsuoka, K. Expression of IL-18 in psoriasis. Arch Dermatol Res 293, 334–342 (2001). https://doi.org/10.1007/s004030100240
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