Amygdala, hippocampus and six cortical gyri were examined for the Lewy body (LB) degeneration and Alzheimer’s disease (AD) type changes in 45 patients with Parkinson’s disease (PD). For detection of LBs, the brain areas were stained with an antibody against alpha-synuclein. The extent of neuropathological lesions was investigated in relation to cognitive dysfunction and apolipoprotein E (apoE) ɛ4 allele dosage. At least one cortical LB was found in 95% of cases (43/45). Furthermore, 40% of cases (18/45) had histological findings of definite AD (CERAD class C). Those PD cases with the apoE ɛ4 allele had a significantly greater number of cortical LBs than those without the apoE ɛ4 allele, but this was statistically significant only in precentral, angular and temporal gyri. The LB density correlated better with the number of plaques than with the density of tangles. The number of LBs in several cortical areas correlated significantly with the cognitive impairment. In stepwise linear regression analysis, the number of LBs in the cingulate gyrus and the amount of tangles in the temporal cortex remained statistically significant. When the CERAD class C was excluded, the correlation between cognitive decline and the number of LBs in cortical areas became even more pronounced. A stepwise linear regression analysis in these cases found the number of LBs in the frontal gyrus to be the statistically most significant predictor of cognitive impairment. This study shows, for the first time, that in PD, alpha-synuclein-positive cortical LBs are associated with cognitive impairment independent of AD-type pathology.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Pathology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland e-mail: matroy@utu.fi, Tel.: +358-2-2613969, Fax: +358-2-3337459, , , , , , FI
P. M. Mattila, M. Röyttä & P. M. Mattila
Department of Neurology, University of Turku, Turku, Finland, , , , , , FI
J. O. Rinne
Department of Biostatistics, University of Turku, Turku, Finland, , , , , , FI
H. Helenius
Department of Research (Neuropathology), Mayo Clinic Jacksonville, Jacksonville, Florida, USA, , , , , , US
D. W. Dickson
Received: 20 August 1999 / Revised, accepted: 4 November 1999
About this article Cite this articleMattila, P., Rinne, J., Helenius, H. et al. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson’s disease. Acta Neuropathol 100, 285–290 (2000). https://doi.org/10.1007/s004019900168
Issue Date: July 2000
DOI: https://doi.org/10.1007/s004019900168
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