Apolipoprotein E (apoE) genotypes were analyzed in a subset of demented very old patients who share a uniform neuropathological picture consisting of various numbers of neurofibrillary tangles (NFT) in allocortical areas of the inferomedial temporal lobe without significant numbers of either diffuse amyloid or neuritic plaques. Among 18 patients with this condition referred to as NFT-predominant senile dementia (average age at death 87 ± 4.7 years), we found allele frequencies of 0.11 ɛ2, 0.86 ɛ3 and 0.03 ɛ4, which are significantly different from allele frequencies reported in Alzheimer’s disease (0.04 ɛ2, 0.59 ɛ3 and 0.38 ɛ4). The low prevalence of the apoE ɛ4 allele in this subset of patients is striking and suggests that NFT-predominant senile dementia is a dementing neurodegenerative disease in which the deposition of Aβ-amyloid did not occur, possibly due to protective effects of ɛ2 and/or ɛ3 alleles or lack of a promoting effect of apoE ɛ4 on amyloidogenesis. We propose that NFT-predominant dementia is a variant of Alzheimer’s disease occurring in the very old.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsLudwig Boltzmann Institute of Clinical Neurobiology, Department of Neurology, Lainz Hospital, Wolkersbergenstrasse 1, A-1130 Vienna, Austria Fax: 43-1-801-10-3685, , , , , , AT
C. Bancher & K. Jellinger
Laboratory of Molecular Neuropathology, Institute of Neuropathology, Hannover Medical School, Hannover, Germany, , , , , , DE
R. Egensperger
Laboratory of Molecular Neuropathology, Institute of Neuropathology, University of Munich, Munich, Germany, , , , , , DE
S. Kösel
Max-Planck Institute of Psychiatry, Department of Neuromorphology, Martinsried, Germany, , , , , , DE
M. B. Graeber
Received: 17 July 1997 / Accepted: 31 July 1997
About this article Cite this articleBancher, C., Egensperger, R., Kösel, S. et al. Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia. Acta Neuropathol 94, 403–409 (1997). https://doi.org/10.1007/s004010050726
Issue Date: October 1997
DOI: https://doi.org/10.1007/s004010050726
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