Amygdalae of patients with Alzheimer’s disease (AD), Parkinson’s disease, Down’s syndrome, diffuse Lewy body disease or a combination of these diseases were probed with antibodies to neurofilament proteins as well as with Lewy body (LB)- and paired helical filament-specific antibodies. The results indicate that the amygdala is severely affected by the accumulation of both neurofibrillary tangles (NFTs) and LBs in most cases of the diseases mentioned above, and that amygdala LBs have a similar epitope composition to that of LBs in the brain stem and cerebral cortex. While large numbers of both LBs and NFTs were seen in different neurons within the amygdala, these two lesions frequently occurred together in the same neurons of the amygdala. These findings are in contrast to other sites that accumulate LBs and NFTs, but rarely both lesions in the same neuron. Thus, amygdala neurons may be selectively vulnerable to developing both LBs and NFTs, and these inclusions may play a role in the massive degeneration of these neurons in AD and LB disorders of the elderly.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, Maloney Building, Basement, Room A009, 3400 Spruce Street, Philadelphia, PA 19104–4283, USA, , , , , , US
M. L. Schmidt, John A. Martin, Virginia M.-Y. Lee & John Q. Trojanowski
Received: 6 September 1995 / Revised, accepted: 30 October 1995
About this article Cite this articleSchmidt, M., Martin, J., Lee, VY. et al. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer’s disease and Lewy body disorders. Acta Neuropathol 91, 475–481 (1996). https://doi.org/10.1007/s004010050454
Issue Date: April 1996
DOI: https://doi.org/10.1007/s004010050454
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