Alzheimer’s disease (AD) is the most prevalent neurological condition affecting industrialized nations and will rapidly become a healthcare crisis as the population ages. Currently, the post-mortem histological observation of amyloid plaques and neurofibrillary tangles is the only definitive diagnosis available for AD. A pre-mortem biological or physiological marker specific for AD used in conjunction with current neurological and memory testing could add a great deal of confidence to the diagnosis of AD and potentially allow therapeutic intervention much earlier in the disease process.
Discussion and conclusionOur group has developed MRI techniques to detect individual amyloid plaques in AD transgenic mouse brain in vivo. We are also developing contrast-enhancing agents to increase the specificity of detection of amyloid plaques. Such in vivo imaging of amyloid plaques will also allow the evaluation of anti-amyloid therapies being developed by the pharmaceutical industry in pre-clinical trials of AD transgenic mice. This short review briefly discusses our progress in these areas.
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This work was supported by the National Institutes of Health grants AG22034 (JFP), P41 RR008079 (MG), and P30 NS057091 (MG), and the Minnesota Partnership for Biotechnology and Medical Genomics.
Conflict of interest statementThe authors declare that they have no relevant financial or any other interests in this manuscript.
Author information Authors and AffiliationsMolecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA
Thomas M. Wengenack & Joseph F. Poduslo
Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA
Clifford R. Jack Jr.
Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN, 55455, USA
Michael Garwood
Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA
Michael Garwood
Correspondence to Joseph F. Poduslo.
About this article Cite this articleWengenack, T.M., Jack, C.R., Garwood, M. et al. MR Microimaging of amyloid plaques in Alzheimer’s disease transgenic mice. Eur J Nucl Med Mol Imaging 35 (Suppl 1), 82–88 (2008). https://doi.org/10.1007/s00259-007-0706-9
Published: 01 February 2008
Issue Date: March 2008
DOI: https://doi.org/10.1007/s00259-007-0706-9
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