Sequences of exons 6 and 7 of the O allele of the ABO gene were studied in 317 individuals of the O phenotype from five different ethnic groups (Basques, Berbers, Akans from the Ivory Coast, and Amerindians: Cayapas from Ecuador and Aymaras from Bolivia). Twenty-one O alleles were characterized, among which 9 differed from all O alleles reported to date. The nine alleles differed from either the O01 allele (four out of nine) or O02 allele (five out of nine) by one to three point mutations. The number of different O alleles in population samples varied greatly: the highest number (13) was observed in Akans, and the lowest (5) in Amerindians. Some rare alleles previously reported by others at low frequencies were found with high frequencies in the Akans. The results also revealed a decreasing frequency of O v7 alleles from south to north (Akans, Berbers, Basques). Berbers and Basques share two rare alleles, O v6 and O03, which were not encountered in the other populations studied here.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsLaboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Hôpital Purpan, 1, Place du Docteur Baylac, 31059, Toulouse Cedex, France, , , , ,
Stéphanie Despiau, Pol-Andre Apoil & Antoine Blancher
Laboratoire d'immunohématologie, Etablissement Français du Sang Pyrénées-Méditerranée, Avenue de Grande Bretagne, BP3210, 31027 Toulouse, France, , , , ,
Francis Roubinet & Nathalie Kermarrec
Centre d'Anthropologie, UMR 8555, 37–39 allées Jules Guesde, 31000 Toulouse, France, , , , ,
Jean Michel Dugoujon
Electronic Publication
About this article Cite this articleRoubinet, F., Kermarrec, N., Despiau, S. et al. Molecular polymorphism of O alleles in five populations of different ethnic origins. Immunogenetics 53, 95–104 (2001). https://doi.org/10.1007/s002510100305
Received: 24 October 2000
Accepted: 30 January 2001
Issue Date: March 2001
DOI: https://doi.org/10.1007/s002510100305
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