Like humans, non-human primates express the antigens A and B of the ABO histoblood group system. In chimpanzees, only A and O types are found, while the types A, B, AB, and O are found in macaques. The sequences of exons 6 and 7 of two chimpanzee O alleles (O del and O x), two macaque species O alleles (rhesus monkey and crab-eating macaque), and sequences of exon 7 of two major chimpanzee A alleles (A 1ch and A 2ch) were established. The sequences of cDNAs corresponding to the chimpanzee and rhesus monkey O alleles were characterized from exon 1 to 7 and from exon 4 to 7, respectively. A comparison of our results with ABO gene sequences already published by others demonstrates that human and non-human primate O alleles are species-specific and result from independent silencing mutations. These observations reinforce the hypothesis that the maintenance of the ABO gene polymorphism in primates reflects convergent evolution more than transpecies inheritance of ancestor alleles.
This is a preview of subscription content, log in via an institution to check access.
Access this article Subscribe and saveSpringer+ Basic
€34.99 /Month
Price includes VAT (Germany)
Instant access to the full article PDF.
Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsLaboratoire d'Immunohématologie, Etablissement de Transfusion Sanguine Pyrénées-Garonne, Etablissement de Toulouse, Avenue de Grande Bretagne, B.P. 3210, 31027 Toulouse Cedex, France, , , , , , FR
Nathalie Kermarrec & Francis Roubinet
Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Pavillon Charles Lefebvre, Hôpital Purpan, 31059 Toulouse Cedex, France E-mail: blancher@mail.easynet.fr, Tel.: +33-561-779187, Fax: +33-561-779059, , , , , , FR
Pol-André Apoil & A. Blancher
Received: 30 July 1998 / Revised: 12 December 1998
About this article Cite this articleKermarrec, N., Roubinet, F., Apoil, PA. et al. Comparison of allele O sequences of the human and non-human primate ABO system. Immunogenetics 49, 517–526 (1999). https://doi.org/10.1007/s002510050529
Issue Date: May 1999
DOI: https://doi.org/10.1007/s002510050529
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4