Rationale and objectives: Because of known and imputed roles of dopaminergic and nicotinic cholinergic systems in a variety of neurological and neuropsychiatric disorders, combined neurochemical and behavioral methods assessments were made to study the intermodulatory roles of these neurochemical systems. Methods: Rats were treated daily during postnatal ontogeny with the dopamine D2/D3 agonist, quinpirole (QNP) HCl (1.0 mg/kg/day), for the first 3 weeks from birth. This priming process replicated previous findings of behavioral sensitization, manifested as hyperlocomotion, increased paw treading with jumping, and increased yawning. Results: All effects were partially or totally blocked by acute treatment with nicotine (0.3 mg/kg, i.p.). The effects of nicotine, in turn, were partially or totally blocked by the nicotinic antagonist, mecamylamine (1.0 mg/kg, i.p.). In concert with these behavioral actions, QNP-primed rats displayed greater binding of [3H]cytisine in midbrain and cerebellum and greater [125I]α-bungarotoxin binding in hippocampus and striatum. Conclusions: Accordingly, these selective ligands for α4β2 and α7 nicotinic receptors, respectively, demonstrate that nicotinic receptors are altered by dopamine D2/D3 agonist treatment of rats with primed dopamine receptors. We propose that nicotinic agonists may have a therapeutic benefit in behavioral disorders brought about by central dopaminergic imbalance.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Pharmacology, College of Medicine, Howard University, 520W Street N.W., Washington, DC 20059, USA e-mail: ytizabi@howard.edu Fax: +1-202-8064453, , , , , , US
Y. Tizabi & Robert L. Copeland Jr.
Department of Pharmacology, Silesian Academy of Medicine, 41–408 Zabrze, Poland, , , , , , PL
Ryszard Brus
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA, , , , , , US
Richard M. Kostrzewa
Received: 1 January 1999 / Final version: 25 March 1999
About this article Cite this articleTizabi, Y., Copeland Jr., R., Brus, R. et al. Nicotine blocks quinpirole-induced behavior in rats: psychiatric implications. Psychopharmacology 145, 433–441 (1999). https://doi.org/10.1007/s002130051078
Issue Date: August 1999
DOI: https://doi.org/10.1007/s002130051078
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