Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsSection on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892-1375, USA, , , , , , US
J. N. Crawley & R. Paylor
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR 97201, USA, , , , , , US
John K. Belknap & John C. Crabbe
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA, , , , , , US
Allan Collins & Jeanne M. Wehner
The Jackson Laboratory, Bar Harbor, ME 04609, USA, , , , , , US
Wayne Frankel
Department of Psychology, Oberlin College, Oberlin, OH 44074-1086, USA, , , , , , US
Norman Henderson
Department of Psychiatry, State University of New York, Stony Brook, NY 11794–8101, USA, , , , , , US
Robert J. Hitzemann
Biobehavioral Sciences Graduate Degree Program and Department of Psychology, University of Connecticut, Storrs, CT 06269-4154, USA, , , , , , US
Stephen C. Maxson
Molecular Neurobiology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224, USA, , , , , , TP
Lucinda L. Miner
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA, , , , , , US
Alcino J. Silva
Laboratory of Genetic Disease Research, National Institute, Human Genome Research Institute, Bethesda, MD 20892-4470, USA, , , , , , US
Anthony Wynshaw-Boris
Received: 8 November 1996 / Final version: 15 March 1997
About this article Cite this articleCrawley, J., Belknap, J., Collins, A. et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132, 107–124 (1997). https://doi.org/10.1007/s002130050327
Issue Date: July 1997
DOI: https://doi.org/10.1007/s002130050327
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