Studies with laboratory animals have consistently demonstrated a role for dopamine in mediating the discriminative stimulus (i.e., interoceptive) effects of amphetamine. For example, D2 dopamine agonists mimic the discriminative stimulus effects of amphetamine and D1 and D2 dopamine antagonists generally block them. The discriminative stimulus effects of drugs in animals are believed to parallel their subjective effects in humans. Therefore, it is often assumed that dopamine plays a role in amphetamine-induced subjective effects in humans and it would be reasonable to expect that dopamine antagonists would block the subjective effects of amphetamine. Few studies have tested this hypothesis directly, and those that have have yielded inconsistent results. This paper will review data regarding the effects of dopamine agonists and antagonists on the discriminative stimulus effects of amphetamine in animals and its subjective effects in humans. Possible explanations for the discrepancies between animal and human data will be discussed, and classical assumptions underlying the use of animal models of drug effects will be examined.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Psychiatry, Duke University, 151-S VA Medical Center, 508 Fulton Street, Durham, NC 27705, USA, , , , , , US
L. H. Brauer
Department of Psychology, Liverpool University, P.O. Box 147, Liverpool L69 3BX, UK, , , , , , GB
Andrew J. Goudie
Department of Psychiatry, University of Chicago, MC3077, 5841 S. Maryland Avenue, Chicago, IL 60637, USA, , , , , , US
Harriet de Wit
Received: 7 March 1996 / Final version: 6 August 1996
About this article Cite this articleBrauer, L., Goudie, A. & de Wit, H. Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data. Psychopharmacology 130, 2–13 (1997). https://doi.org/10.1007/s002130050207
Issue Date: March 1997
DOI: https://doi.org/10.1007/s002130050207
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