Andreen L, Sundstrom-Poromaa I, Bixo M, Andersson A, Nyberg S, Backstrom T (2005) Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone. Psychoneuroendocrinology 30:212–224
Backstrom T, Andersson A, Baird DT, Selstam G (1986) The human corpus luteum secretes 5 alpha-pregnane-3,20-dione. Acta Endocrinol (Copenh) 111:116–121
Baloh RW, Sills AW, Kumley WE, Honrubia V (1975) Quantitative measurement of saccade amplitude, duration, and velocity. Neurology 25:1065–1070
Beauchamp MH, Ormerod BK, Jhamandas K, Boegman RJ, Beninger RJ (2000) Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats. Pharmacol Biochem Behav 67:29–35
Bicikova M, Dibbelt L, Hill M, Hampl R, Starka L (1998) Allopregnanolone in women with premenstrual syndrome. Horm Metab Res 30:227–230
Bicikova M, Tallova J, Hill M, Krausova Z, Hampl R (2000) Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder. Neurochem Res 25:1623–1627
Bitran D, Hilvers RJ, Kellogg CK (1991) Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res 561:157–161
Bitran D, Shiekh M, McLeod M (1995) Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors. J Neuroendocrinol 7:171–177
Bitran D, Dugan M, Renda P, Ellis R, Foley M (1999) Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Res 850:217–224
Carl P, Hogskilde S, Nielsen JW, Sorensen MB, Lindholm M, Karlen B, Backstrom T (1990) Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. Anaesthesia 45:189–197
Carl P, Hogskilde S, Lang-Jensen T, Bach V, Jacobsen J, Sorensen MB, Gralls M, Widlund L (1994) Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol Scand 38:734–741
de Lignieres B, Dennerstein L, Backstrom T (1995) Influence of route of administration on progesterone metabolism. Maturitas 21:251–257
Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH (2002) Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry 59:851–858
Finn DA, Phillips TJ, Okorn DM, Chester JA, Cunningham CL (1997) Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice. Pharmacol Biochem Behav 56:261–264
Freeman EW, Purdy RH, Coutifaris C, Rickels K, Paul SM (1993) Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. Neuroendocrinology 58:478–484
Friedman L, Gibbs TT, Farb DH (1993) Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol 44:191–197
Gee KW, McCauley LD, Lan NC (1995) A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Crit Rev Neurobiol 9:207–227
Genazzani AR, Petraglia F, Bernardi F, Casarosa E, Salvestroni C, Tonetti A, Nappi RE, Luisi S, Palumbo M, Purdy RH, Luisi M (1998) Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. J Clin Endocrinol Metab 83:2099–2103
Gentles W, Thomas EL (1971) Commentary. Effect of benzodiazepines upon saccadic eye movements in man. Clin Pharmacol Ther 12:563–574
Girdler SS, Straneva PA, Light KC, Pedersen CA, Morrow AL (2001) Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder. Biol Psychiatry 49:788–797
Glue P, White E, Wilson S, Ball DM, Nutt DJ (1991) Pharmacology of saccadic eye movements in man. 2. Effects of the alpha 2-adrenoceptor ligands idazoxan and clonidine. Psychopharmacology (Berl) 105:368–373
Gulinello M, Gong QH, Li X, Smith SS (2001) Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res 910:55–66
Harrison NL, Simmonds MA (1984) Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res 323:287–292
Hill M, Parizek A, Bicikova M, Havlikova H, Klak J, Fait T, Cibula D, Hampl R, Cegan A, Sulcova J, Starka L (2000) Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers. J Steroid Biochem Mol Biol 75:237–244
Hill M, Bicikova M, Parizek A, Havlikova H, Klak J, Fajt T, Meloun M, Cibula D, Cegan A, Sulcova J, Hampl R, Starka L (2001) Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal blood: 2. Time profiles of pregnanolone isomers. J Steroid Biochem Mol Biol 78:51–57
Hodges JK, Heistermann M, Beard A, van Aarde RJ (1997) Concentrations of progesterone and the 5 alpha-reduced progestins, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one, in luteal tissue and circulating blood and their relationship to luteal function in the African elephant, Loxodonta africana. Biol Reprod 56:640–646
Holzbauer M (1976) Physiological aspects of steroids with anaesthetic properties. Med Biol 54:227–242
Hommer DW, Matsuo V, Wolkowitz O, Chrousos G, Greenblatt DJ, Weingartner H, Paul SM (1986) Benzodiazepine sensitivity in normal human subjects. Arch Gen Psychiatry 43:542–551
Lan NC, Bolger MB, Gee KW (1991) Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor. Neurochem Res 16:347–356
Lancel M, Faulhaber J, Schiffelholz T, Romeo E, Di Michele F, Holsboer F, Rupprecht R (1997) Allopregnanolone affects sleep in a benzodiazepine-like fashion. J Pharmacol Exp Ther 282:1213–1218
Landgren S, Wang MD, Backstrom T, Johansson S (1998) Interaction between 3 alpha-hydroxy-5 alpha-pregnan-20-one and carbachol in the control of neuronal excitability in hippocampal slices of female rats in defined phases of the oestrus. Acta Physiol Scand 162:77–88
Luisi S, Petraglia F, Benedetto C, Nappi RE, Bernardi F, Fadalti M, Reis FM, Luisi M, Genazzani AR (2000) Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery, and in hypertensive patients. J Clin Endocrinol Metab 85:2429–2433
Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004–1007
Marshall RW, Richens A (1989) An IBM-based system for the generation, collection and analysis of saccadic and smooth pursuit eye movements. Br J Clin Pharmacol 28:752–753
Marshall RW, Griffiths AN, Richens A (1985) A microcomputer system to assess CNS depression from the analysis of the dynamics of saccadic eye movements. Br J Clin Pharmacol 20:304–305
McCormack HM, Horne DJ, Sheather S (1988) Clinical applications of visual analogue scales: a critical review. Psychol Med 18:1007–1019
Milewich L, Gant NF, Schwarz BE, Chen GT, MacDonald PC (1979) 5 alpha-Reductase activity in human placenta. Am J Obstet Gynecol 133:611–617
Monteleone P, Luisi S, Tonetti A, Bernardi F, Genazzani AD, Luisi M, Petraglia F, Genazzani AR (2000) Allopregnanolone concentrations and premenstrual syndrome. Eur J Endocrinol 142:269–273
Morrow AL, Janis GC, VanDoren MJ, Matthews DB, Samson HH, Janak PH, Grant KA (1999) Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? Alcohol Clin Exp Res 23:1933–1940
Morrow AL, VanDoren MJ, Penland SN, Matthews DB, Fleming R, Penland S (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brains Res Rev 37:98–109
Navarro PA, Kaddouz D, de Ziegler D, Silva de Sa MF, Ferriani RA (2003) Vaginal administration of allopregnanolone to postmenopausal women undergoing estrogen replacement therapy: preliminary results. Maturitas 46:147–152
Norberg L, Wahlstrom G, Backstrom T (1987) The anaesthetic potency of 3 alpha-hydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 beta-pregnan-20-one determined with an intravenous EEG-threshold method in male rats. Pharmacol Toxicol 61:42–47
Nyberg S, Wahlstrom G, Backstrom T, Sundstrom Poromaa I (2004) Altered sensitivity to alcohol in the late luteal phase among patients with premenstrual dysphoric disorder. Psychoneuroendocrinology 29:767–777
Nyberg S, Andersson A, Zingmark, Wahlström G, Bäckström T, Sundström Poromaa I (2005) The effect of a low dose of alcohol on allopregnanolone serum concentrations across the menstrual cycle in women with severe premenstrual syndrome and controls. Psychoneuroendocrinology 30:892–901
Ottander U, Sundström Poromaa I, Bjurulf E, Skytt Å, Bäckström T, Olofsson JI (2005) Allopregnanolone and pregnanolone are produced by the human corpus luteum. Mol Cell Endocrinol 239(1–2):37–44
Parizek A, Hill M, Kancheva R, Havlikova H, Kancheva L, Cindr J, Paskova A, Pouzar V, Cerny I, Drbohlav P, Hajek Z, Starka L (2005) Neuroactive pregnanolone isomers during pregnancy. J Clin Endocrinol Metab 90:395–403
Pearson Murphy BE, Allison CM (2000) Determination of progesterone and some of its neuroactive ring A-reduced metabolites in human serum. J Steroid Biochem Mol Biol 74:137–142
Purdy RH, Moore PH Jr, Rao PN, Hagino N, Yamaguchi T, Schmidt P, Rubinow DR, Morrow AL, Paul SM (1990) Radioimmunoassay of 3 alpha-hydroxy-5 alpha-pregnan-20-one in rat and human plasma. Steroids 55:290–296
Rapkin AJ, Morgan M, Goldman L, Brann DW, Simone D, Mahesh VB (1997) Progesterone metabolite allopregnanolone in women with premenstrual syndrome. Obstet Gynecol 90:709–714
Romeo E, Strohle A, Spalletta G, di Michele F, Hermann B, Holsboer F, Pasini A, Rupprecht R (1998) Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry 155:910–913
Roy-Byrne PP, Cowley DS, Greenblatt DJ, Shader RI, Hommer D (1990) Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry 47:534–538
Schmidt PJ, Purdy RH, Moore PH Jr, Paul SM, Rubinow DR (1994) Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects. J Clin Endocrinol Metab 79:1256–1260
Spitzer RL, Williams JB, Kroenke K, Linzer M, deGruy FV III, Hahn SR, Brody D, Johnson JG (1994) Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA 272:1749–1756
Stoffel-Wagner B (2001) Neurosteroid metabolism in the human brain. Eur J Endocrinol 145:669–679
Strohle A, Romeo E, di Michele F, Pasini A, Yassouridis A, Holsboer F, Rupprecht R (2002) GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am J Psychiatry 159:145–147
Sundstrom I, Backstrom T (1998) Patients with premenstrual syndrome have decreased saccadic eye velocity compared to control subjects. Biol Psychiatry 44:755–764
Sundstrom I, Ashbrook D, Backstrom T (1997) Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: a pilot study. Psychoneuroendocrinology 22:25–38
Sundstrom I, Andersson A, Nyberg S, Ashbrook D, Purdy RH, Backstrom T (1998) Patients with premenstrual syndrome have a different sensitivity to a neuroactive steroid during the menstrual cycle compared to control subjects. Neuroendocrinology 67:126–138
Sundstrom I, Spigset O, Andersson A, Appelblad P, Backstrom T (1999) Lack of influence of menstrual cycle and premenstrual syndrome diagnosis on pregnanolone pharmacokinetics. Eur J Clin Pharmacol 55:125–130
Torres JM, Ortega E (2003) Alcohol intoxication increases allopregnanolone levels in female adolescent humans. Neuropsychopharmacology 28:1207–1209
Turkmen S, Lundgren P, Birzniece V, Zingmark E, Backstrom T, Johansson IM (2004) 3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone. Eur J Neurosci 20:1604–1612
Vanselow W, Dennerstein L, Greenwood KM, de Lignieres B (1996) Effect of progesterone and its 5 alpha and 5 beta metabolites on symptoms of premenstrual syndrome according to route of administration. J Psychosom Obstet Gynaecol 17:29–38
Wang M, Hammarback S, Lindhe BA, Backstrom T (1995) Treatment of premenstrual syndrome by spironolactone: a double-blind, placebo-controlled study. Acta Obstet Gynecol Scand 74:803–808
Wang M, Seippel L, Purdy RH, Backstrom T (1996) Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one. J Clin Endocrinol Metab 81:1076–1082
Wieland S, Lan NC, Mirasedeghi S, Gee KW (1991) Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res 565:263–268
Wihlback AC, Sundstrom-Poromaa I, Nyberg S, Backstrom T (2001) Sensitivity to a neurosteroid is increased during addition of progestagen to postmenopausal hormone replacement therapy. Neuroendocrinology 73:397–407
Wihlback AC, Nyberg S, Backstrom T, Bixo M, Sundstrom-Poromaa I (2005) Estradiol and the addition of progesterone increase the sensitivity to a neurosteroid in postmenopausal women. Psychoneuroendocrinology 30:38–50
Wyatt K, Dimmock P, Jones P, Obhrai M, O'Brien S (2001) Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review. BMJ 323:776–780
Yu R, Follesa P, Ticku MK (1996a) Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment. Brain Res Mol Brain Res 41:163–168
Yu R, Hay M, Ticku MK (1996b) Chronic neurosteroid treatment attenuates single cell GABAA response and its potentiation by modulators in cortical neurons. Brain Res 706:160–162
Zhu D, Wang MD, Backstrom T, Wahlstrom G (2001) Evaluation and comparison of the pharmacokinetic and pharmacodynamic properties of allopregnanolone and pregnanolone at induction of anaesthesia in the male rat. Br J Anaesth 86:403–412
Zhu D, Birzniece V, Backstrom T, Wahlstrom G (2004) Dynamic aspects of acute tolerance to allopregnanolone evaluated using anaesthesia threshold in male rats. Br J Anaesth 93:560–567
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