Aceto MD, Mckean DB, Pearl J (1969) Effects of opiates and opiate antagonists on the straub tail reaction in mice. Br J Pharmacol 36:239–255

Google Scholar 

Aghajanian GK, Marek GJ (1999) Serotonin and hallucinogens. Neuropsychopharmacology 21(2S):16S–23S

PubMed  CAS  Google Scholar 

Boulton CS, Handley SL (1973) Factors modifying the head-twitch response to 5-hydroxytryptophan. Psychopharmacologia 31(3):205–214

Article  PubMed  CAS  Google Scholar 

Brauer LH, Goudie AJ, de Wit H (1997) Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data. Psychopharmacology 130:2–13

Article  PubMed  CAS  Google Scholar 

Brown JB (2002) Schedules of controlled substances: temporary placement of 2,5-dimethoxy-4-(n)-propylthiophenethylamine into Schedule I. Fed Regist 67(183):59163–59165

Google Scholar 

Colpaert FC, Janssen PAJ (1983) The head twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist. Neuropharmacology 22(8):993–1000

Article  PubMed  CAS  Google Scholar 

Corne SJ, Pickering RW (1967) A possible correlation between drug-induced hallucinations in man and a behavioral response in mice. Psychopharmacologia 11:65–78

Article  PubMed  CAS  Google Scholar 

Corne SJ, Pickering RW, Warner BT (1963) A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine. Br J Pharmacol 20:106–120

CAS  Google Scholar 

Darmani NA (1998) Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacol Biochem Behav 60(1):83–90

Article  PubMed  CAS  Google Scholar 

Darmani NA, Martin BR, Glennon RA (1990a) Withdrawal from chronic treatment with (±)-DOI causes supersensitivity to 5-HT₂ receptor-induced head-twitch behavior in mice. Eur J Pharmacol 186:115–118

Article  PubMed  CAS  Google Scholar 

Darmani NA, Martin BR, Pandy U, Glennon RA (1990b) Do functional relationships exist between 5-HT_1A and 5-HT₂ receptors? Pharmacol Biochem Behav 36(4):901–906

Article  PubMed  CAS  Google Scholar 

Darmani NA, Martin BR, Glennon RA (1992) Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. J Pharmacol Exp Ther 262(2):692–698

PubMed  CAS  Google Scholar 

Dave KD, Harvey JA, Aloyo VJ (2002) A novel behavioral model that discriminates between 5-HT_2A and 5-HT_2C receptor activation. Pharmacol Biochem Behav 72:371–378

Article  PubMed  CAS  Google Scholar 

de Boer D, Bosman I (2004) A new trend in drugs-of-abuse; the 2C-series of phenethylamine designer drugs. Pharm World Sci 26(2):110–113

Article  PubMed  Google Scholar 

Dursun SM, Handley SL (1996) Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5-HT_2A receptors are active under physiological conditions. Psychopharmacology 128:198–205

Article  PubMed  CAS  Google Scholar 

Fantegrossi WE, Kilbourn ME, Woods JH (2004a) Actions of the 5-HT_2A antagonist M100907 in serotonin-depleted mice. 2004 Experimental Biology meeting abstracts [accessed at http://select.biosis.org/faseb]. FASEB J, 18, Abstract #637.2

Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH (2004b) Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology 173(3–4):270–277

Article  PubMed  CAS  Google Scholar 

Fiorella D, Palumbo PA, Rabin RA, Winter JC (1995a) The time-dependent stimulus effects of R(−)-2,5-dimethoxy-4-methamphetamine (DOM): implications for drug-induced stimulus control as a method for the study of hallucinogenic agents. Psychopharmacology 119:239–245

Article  PubMed  CAS  Google Scholar 

Fiorella D, Rabin RA, Winter JC (1995b) The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs I: antagonist correlation analysis. Psychopharmacology 121:347–356

Article  PubMed  CAS  Google Scholar 

Fozard JR, Palfreyman MG (1979) Metoclopramide antagonism of 5-HT-induced “wet-dog” shake behavior in the rat. N-S Arch Pharmacol 307:135–142

Article  CAS  Google Scholar 

Glennon RA, Young R, Jacyno JM, Slusher M, Rosecrans JA (1983a) DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. Eur J Pharmacol 86:453–459

Article  PubMed  CAS  Google Scholar 

Glennon RA, Rosecrans JA, Young R (1983b) Drug-induced discrimination: a description of the paradigm and a review of its specific application to the study of hallucinogenic agents. Med Res Rev 3:289–340

Article  PubMed  CAS  Google Scholar 

Goodwin GM, Green AR (1985) A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT₁ and 5-HT₂ receptors. Br J Pharmacol 84(3):743–755

PubMed  CAS  Google Scholar 

Green AR, O'Shaughnessy K, Hammond M, Schachter M, Grahame-Smith DG (1983) Inhibition of 5-hydroxytryptamine-mediated behaviours by the putative 5-HT₂ receptor antagonist pirenperone. Neuropharmacology 22:573–578

Article  PubMed  CAS  Google Scholar 

Handley SL, Singh L (1986) Neurotransmitters and shaking behavior: more than a “gut bath” for the brain. Trends Pharmacol Sci 7:324–328

Article  CAS  Google Scholar 

Khorana N, Pullagurla MR, Dukat M, Young R, Glennon R (2004) Stimulus effects of three sulfur-containing psychoactive agents. Pharmacol Biochem Behav 78:821–826

Article  PubMed  CAS  Google Scholar 

Leonhart MM (2004) Schedules of controlled substances: placement of 2,5-dimethoxy-4-(n)-propylthiophenethylamine and N-benzylpiperazine into Schedule 1 of the controlled substances act. Fed Regist 69(53):12795–12797

Google Scholar 

Lucki I, Nobler MS, Frazer A (1984) Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. J Pharmacol Exp Ther 228:133–139

PubMed  CAS  Google Scholar 

Nichols DE (2004) Hallucinogens. Pharmacol Ther 101:131–181

Article  PubMed  CAS  Google Scholar 

Ortmann R, Biscoff S, Radeke E, Bueche O, Delini-Stula A (1982) Correlation between different measures of antiserotonin activity of drugs. Naunyn-Schmiedeberg's Arch Pharmacol 321:265–270

Article  CAS  Google Scholar 

Peroutka SJ, Lebovitz RM, Snyder SH (1981) Two distinct central serotonin receptors with different physiological functions. Science (Wash DC) 212:827–829

Article  CAS  Google Scholar 

Sadzot B, Baraban JM, Glennon RA, Lyon RA (1989) Hallucinogenic drug interactions at human brain 5-HT₂ receptors: implications for treating LSD-induced hallucinogenesis. Psychopharmacology 98(4):495–499

Article  PubMed  CAS  Google Scholar 

Sanger DJ, Benavides J, Perrault G, Morel E, Cohen C, Joly D, Zivkovic B (1994) Recent developments in the behavioral pharmacology of benzodiazepine (ω) receptors: evidence for functional significance of receptor subtypes. Neurosci Biobehav Rev 18:355–372

Article  PubMed  CAS  Google Scholar 

Schreiber R, Brocco M, Audinot V, Gobert A, Veiga S, Millan MJ (1995) (1-(2,5-Dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT)_2A receptors: modulation by novel 5-HT_2A/2C antagonists, D₁ antagonists and 5-HT_1A agonists. J Pharmacol Exp Ther 273:101–112

PubMed  CAS  Google Scholar 

Schuster C, Johanson C (1988) Relationship between the discriminative stimulus properties and subjective effects of drugs. In: Colpaert F, Balster R (eds) Transduction mechanisms of drug stimuli. Springer, Berlin Heidelberg New York, pp 161–175

Google Scholar 

Shulgin A, Shulgin A (1991) PIHKAL: a chemical love story. Transform Press, Berkley, pp 567–571

Google Scholar 

Strassman RJ, Qualls CR, Berg LM (1996) Differential tolerance to biological and subjective effects of 4 closely spaced doses of N,N-dimethyltryptamine in humans. Biol Psychiatry 39:784–795

Article  PubMed  CAS  Google Scholar 

Vollenweider FX (1998) Advances and pathophysiological models of hallucinogenic drug actions in humans: a preamble to schizophrenia research. Pharmacopsychiatry 31:92–103

Article  PubMed  CAS  Google Scholar 

Winter JC (1978) Stimulus properties of phenethylamine hallucinogens and lysergic acid diethylamide: the role of 5-hydroxytryptamine. J Pharmacol Exp Ther 204:416–423

PubMed  CAS  Google Scholar 

Winter JC, Rabin RA (1988) Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus. Pharmacol Biochem Behav 30:617–624

Article  PubMed  CAS  Google Scholar 

Winter JC, Eckler JR, Rabin RA (2004) Serotonergic/glutamatergic interactions: the effects of mGlu_2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli. Psychopharmacology 172:233–240

Article  PubMed  CAS  Google Scholar