Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of ATP, produced after degradation by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated by purines and some subtypes also by pyrimidines. P2X receptors are ligand-gated ion channel receptors and seven subunits have been identified, which form both homomultimers and heteromultimers. P2Y receptors are G protein-coupled receptors, and eight subtypes have been cloned and characterised to date.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsAutonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
G. Burnstock
Correspondence to G. Burnstock.
Additional informationReceived 22 November 2006; received after revision 11 January 2007; accepted 27 February 2007
About this article Cite this articleBurnstock, G. Purine and pyrimidine receptors. Cell. Mol. Life Sci. 64, 1471 (2007). https://doi.org/10.1007/s00018-007-6497-0
Published: 19 March 2007
DOI: https://doi.org/10.1007/s00018-007-6497-0
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