Objective: To examine the effect of hyaluronic acid (HA) on the induction of superoxide anion by IL-1 in chondrocytes. ¶Materials and Methods: Bovine articular chondrocytes were treated with different concentrations of IL-1. A chemiluminescent probe (L-012) was added to the medium and chemiluminescence detection was used to measure superoxide anion. ¶Results: IL-1 caused induction of superoxide anions in a dose-dependent manner. HA (10–100 <mu>g/ml) countered superoxide induction caused by 20 ng/ml of IL-1. ¶Conclusion: HA can afford protection against cartilage degradation, probably acting as a free-radical scavenger.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Orthopaedic Surgery, Kinki University School of Medicine, Ohno-higashi 377-2, Osaka-sayama, Osaka 589, Japan, , , , , , JP
K. Fukuda, M. Takayama, M. Ueno, M. Oh, S. Asada, F. Kumano & S. Tanaka
Received 7 July 1996; returned for revision 13 August 1996; returned for final revision 16 December 1996; accepted by W. B. van den Berg 16 January 1997
About this article Cite this articleFukuda, K., Takayama, M., Ueno, M. et al. Hyaluronic acid inhibits interleukin-1-induced superoxide anion in bovine chondrocytes. Inflamm. res. 46, 114–117 (1997). https://doi.org/10.1007/s000110050132
Issue Date: March 1997
DOI: https://doi.org/10.1007/s000110050132
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