This review discusses multiple ways in which the endoplasmic reticulum participates in and is influenced by signal transduction pathways. The endoplasmic reticulum provides a Ca2+ store that can be mobilized either by calcium-induced calcium release or by the diffusible messenger inositol 1,4,5-trisphosphate. Depletion of endoplasmic reticulum Ca2+ stores provides a signal that activates surface membrane Ca2+ channels, a process known as capacitative calcium entry. Depletion of endoplasmic reticulum stores can also signal long-term cellular responses such as gene expression and programmed cell death or apoptosis. In addition to serving as a source of cellular signals, the endoplasmic reticulum is also functionally and structurally modified by the Ca2+ and protein kinase C pathways. Elevated cytoplasmic Ca2+ causes a rearrangement and fragmentation of endoplasmic reticulum membranes. Protein kinase C activation reduces the storage capacity of the endoplasmic reticulum Ca2+ pool. In some cell types, protein kinase C inhibits capacitative calcium entry. Protein kinase C activation also protects the endoplasmic reticulum from the structural effects of high cytoplasmic Ca2+. The emerging view is one of a complex network of pathways through which the endoplasmic reticulum and the Ca2+ and protein kinase C signaling pathways interact at various levels regulating cellular structure and function.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsCalcium Regulation Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences—NIH, PO Box 12233, Research Triangle Park (North Carolina 27709, USA), Fax +1 919 541 1898, e-mail: putney@niehs.nih.gov, , , , , , US
J. W. Putney Jr.*
Cystic Fibrosis Pulmonary Research and Training Center, The University of North Carolina School of Medicine, Chapel Hill (North Carolina 27599, USA), , , , , , US
C. M. Pedrosa Ribeiro
Received 14 February 2000; received after revision 23 March 2000; accepted 31 March 2000
About this article Cite this articlePutney Jr.*, J., Pedrosa Ribeiro, C. Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores . CMLS, Cell. Mol. Life Sci. 57, 1272–1286 (2000). https://doi.org/10.1007/PL00000765
Issue Date: August 2000
DOI: https://doi.org/10.1007/PL00000765
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