The most widely accepted concept of oxidative damage centers on the formation of hydroxyl radical (OH) which has an extremely short-life and is the major damaging free radical. It was suggested that methamphetamine (METH) toxicity is mediated via production of OH, as measured by 2,3-dihydroxy-benzoic acid (2,3-DHBA). In this study we compared the effects of local caudate nucleus perfusion of METH with systemic administration of METH on OH generation in relation to DA release. Local perfusion of METH (5 mM,140 min) induced a higher level of dopamine (DA) release compared to the first METH injection (10 mg/kg, 3 times, i.p.). No significant correlation was found between changes in extracellular DA levels and OH generation when perfusing METH locally; however, both increased after systemic METH administration.
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Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, NCTR/FDA, 72079, Jefferson, AR, USA
Frederico C. Pereira, Syed Z. Imam & Syed F. Ali
Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Coimbra, Portugal
Frederico C. Pereira, Tice R. Macedo & Carlos F. Ribeiro
Correspondence to Syed F. Ali.
About this article Cite this articlePereira, F.C., Macedo, T.R., Imam, S.Z. et al. Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: A microdialysis study. neurotox res 6, 149–152 (2004). https://doi.org/10.1007/BF03033217
Received: 28 January 2004
Revised: 01 April 2004
Issue Date: January 2004
DOI: https://doi.org/10.1007/BF03033217
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