Akaoka H, Roussel B, Lin J, Chouvet G, Jouvet M (1991) Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci Lett 123:20–22

PubMed  Google Scholar 

Baker LE, Riddle EE, Saunders RB, Appel JB (1993) The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds. Behav Pharmacol 4:69–79

PubMed  Google Scholar 

Balster RL (1991) Drug abuse potential evaluation in animals. Br J Addict 86:1549–1558

PubMed  Google Scholar 

Balster RL, Schuster CR (1973) A comparison ofd-amphetamine,l-amphetamine and methamphetamine self-administration in rhesus monkeys. Pharmacol Biochem Behav 1:67–71

Article  PubMed  Google Scholar 

Balster RL, Woolverton WL (1982) Intravenous buspirone self-administration in rhesus monkeys. J Clin Psychiatry 43:34–37

PubMed  Google Scholar 

Balster RL, Carroll FI, Graham JH, Mansbach RS, Rahman A, Lewin AH, Showalter VM (1991) Potent substituted-β-phenyltropane analogs of cocaine have cocaine-like discriminative stimulus effects. Drug Alcohol Depend 29:145–151

Article  PubMed  Google Scholar 

Bastuji H, Jouvet M (1988) Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuropsychopharmacol Biol Psychiatry 12:695–700

Article  PubMed  Google Scholar 

Beardsley PM, Balster RL, Harris LS (1986) Self-administration of methylenedioxymethamphetamine (MDMA) by rhesus monkeys. Drug Alcohol Depend 18:149–157

Article  PubMed  Google Scholar 

Boivin DB, Montplaisir J, Petit D, Lambert C, Lubin S (1993) Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol 16:46–53

PubMed  Google Scholar 

Bruno A, Nolte KB, Chapin J (1993) Stroke associated with ephedrine use. Neurology 43:1313–1316

PubMed  Google Scholar 

Carney JM, Uwaydah IM, Balster RL (1977) Evaluation of a suspension system for intravenous self-administration studies of water-insoluble compounds in the rhesus monkey. Pharmacol Biochem Behav 7:357–364

Article  PubMed  Google Scholar 

Chait LD (1994) Factors influencing the reinforcing and subjective effects of ephedrine in humans. Psychopharmacology 113:381–387

PubMed  Google Scholar 

Deneau G, Yanagita T, Seevers MH (1969) Self-administration of psychoactive substances by the monkey. Psychopharmacology 16:30–43

Article  Google Scholar 

Duteil J, Rambert FA, Pessonnier J, Hermant J, Gombert R, Assous E (1990) Central α₁-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol 180:49–58

Article  PubMed  Google Scholar 

Fishman MW, Schuster CR, Resnekov L, Shick JFE, Krasnegor NA, Fennell W, Freedman DX (1976) Cardiovascular and subjective effects of intravenous cocaine administration in humans. Arch Gen Psychiatry 33:983–989

PubMed  Google Scholar 

Fuxe K, Janson AM, Rosen L, Finnman U-B, Tanganelli S, Morari M, Goldstein M, Agnati LF (1992) Evidence for protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis. Exp Brain Res 88:117–130

PubMed  Google Scholar 

Gauvin DV, Harland RD, Michaelis RC, Holloway FA (1989) Caffeine-phenylethylamine combinations mimic the cocaine discriminative cue. Life Sci 44:67–73

Article  PubMed  Google Scholar 

Gauvin DV, Moore KR, Youngblood BD, Holloway FA (1993) The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations. Psychopharmacology 110:309–319

Google Scholar 

Hermant J-F, Rambert FA, Duteil J (1991) Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology 103:28–32

Article  PubMed  Google Scholar 

Holtzman SG (1990) Discriminative stimulus effects of drugs: relationship to abuse liability. In: Adler MW, Cowan A (eds) Testing and evaluation of drugs of abuse. Modern methods in pharmacology, vol. 6. Wiley-Liss, New York, pp. 193–210

Google Scholar 

Huang J, Ho BT (1974) Discriminative stimulus properties ofd-amphetamine and related compounds in rats. Pharmacol Biochem Behav 2:669–673

Google Scholar 

Johanson CE, Balster RL (1978) A summary of the results of a drug self-administration study using substitution procedures in rhesus monkey. Bull Narc 30:43–54

Google Scholar 

Kamien JB, Woolverton WL (1989) A pharmacological analysis of the discriminative stimulus properties ofd-amphetamine in rhesus monkeys. J Pharmacol Exp Ther 248:938–946

PubMed  Google Scholar 

Lagarde D, Milhaud C (1990) Electroencephalographic effects of modafinil, an alpha-1-adrenergic psychostimulant, on the sleep of rhesus monkeys. Sleep 13:441–448

PubMed  Google Scholar 

Lamb RJ, Griffiths RR (1990) Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine. Psychopharmacology 102:183–190

Article  PubMed  Google Scholar 

Lin JS, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M (1992) Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 591:319–326

Article  PubMed  Google Scholar 

Mansbach RS, Balster RL (1993) Effects of mazindol on behaviors maintained or occasioned by cocaine. Drug Alcohol Depend 31:183–191

Article  PubMed  Google Scholar 

Mansbach RS, Sannerud CA, Griffiths RR, Balster RL, Harris LS (1990) Intravenous self-administration of 4-methylaminorex in primates. Drug Alcohol Depend 26:137–144

Article  PubMed  Google Scholar 

Martin WR, Sloan MD, Sapira JD, Jasinski DR (1971) Physiologic, subjective and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther 12:245–258

PubMed  Google Scholar 

Mignot E, Nishino S, Guilleminault C, Dement WC (1994) Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 17:436–437

PubMed  Google Scholar 

Pigeau R, Natioh P, Buguet A, McCann C, Baranski J, Taylor M, Thompson M, Mack I (1995) Modafinil,d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 4:212–218

PubMed  Google Scholar 

Rambert FA, Pessonnier J, Duteil J (1990) Modafinil, amphetamine and methylphenidate-induced hyperactivities in mice involve different mechanisms. Eur J Pharmacol 183:455–456

Article  Google Scholar 

Simon P, Panissaud C, Costentin J (1994) The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. Psychopharmacology 114:597–600

PubMed  Google Scholar 

Snoddy AM, Tessel RE (1983) Nisoxetine and amphetamine share discriminative stimulus properties in mice. Pharmacol Biochem Behav 19:205–210

Article  PubMed  Google Scholar 

Terry P, Witkin JM, Katz JL (1994) Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine. J Pharmacol Exp Ther 270:1041–1048

PubMed  Google Scholar 

Touret M, Sallanon-Moulin M, Jouvet M (1995) Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat. Neurosci Lett 189:43–46

Article  PubMed  Google Scholar 

Ueki A, Rosen L, Agnati LF, Hallstrom A, Goiny M, Tanganelli S, Ungerstedt U, Fuxe K (1993a) Evidence for a preventive action of the vigilance-promoting drug modafinil against striatal ischemic injury induced by endothelin-1 in the rat. Exp Brain Res 96:89–99

PubMed  Google Scholar 

Ueki A, Rosen L, Andbjer B, Finnman U-B, Altamimi U, Janson AM, Goldstein M, Agnati LF, Fuxe K (1993b) The vigilance-promoting drug modafinil counteracts the reduction of tyrosine hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway. Exp Brain Res 93:259–270

Article  PubMed  Google Scholar 

Woodward JJ, Mansbach RS, Carroll FI, Balster RL (1991) Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies. Eur J Pharmacol 197:235–236

Article  PubMed  Google Scholar 

Woolverton WL (1991) Discriminative stimulus effects of cocaine. In: Glennon RA, Jarbe TUC, Frankenheim J (eds) Drug discrimination: applications to drug abuse research. NIDA Research Monograph Series 116, DHHS Publication number (ADM)92-1878, pp 61–74

Woolverton WL, Nader MA (1990) Experimental evaluation of the reinforcing effects of drugs. In: Adler MW, Cowan A (eds) Testing and evaluation of drugs of abuse. Modern methods in pharmacology, vol. 6. Wiley-Liss, New York, pp 165–192

Google Scholar