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Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens

Three experiments examined the behavioural, pharmacological and neural specificity of the previously reported potentiation of responding with conditioned reinforcement following intra-accumbensd-amphetamine, by studying the effects of intraaccumbens dopamine (DA) and noradrenaline, using an acquisition of a new response procedure. In experiment 1, the effects of intra-cerebral DA infusions (5, 20, 50 µg/2 µl) were compared in four conditions: (i) intra-accumbens DA following positive pairing of the conditioned stimulus (CS) and water during training; (ii) as (i) but also following a systemic dose of the DA receptor antagonist alpha-flupenthixol; (iii) intra-accumbens DA following random pairing of the CS and water during training; and (iv) as (i) but with intra-caudate rather than intra-accumbens DA. The results showed that only with intra-accumbens DA in the positive pairing condition was there a significant dose-dependent increase in responding. In experiment 2, the effects of a higher range of doses (20, 100, 200 µg) and smaller infusion volume (5, 25, 50 µg/l µl) of intra-accumbens DA were studied, in comparison with a similar range of doses (5, 25, 50 µg/l µl) of intra-accumbens noradrenaline (NA). Only DA produced a selective, dose-dependent increase in responding with conditioned reinforcement. In experiment 3 neurotoxic lesions of the dorsal noradrenergic bundle (DNAB) using 6-hydroxydopamine producing profound (about 90%) depletion of cortical and nucleus accumbens NA levels had no effect on the increased responding with conditioned reinforcement produced by intra-accumbensd-amphetamine (3, 10, 30 µg/l µl). The results are discussed in terms of the neurochemical mediation of the potentiation of the effects of conditioned reinforcers byd-amphetamine and the role of DA-dependent mechanisms of the nucleus accumbens in reward-related processes.

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1. M. Cador

   Present address: Unité INSERM 259, Rue Camille Saint-Säens, Domaine de Carrèire, Université de Bordeaux II, F-33077, Bordeaux Cédex, France

2. J. R. Taylor

   Present address: Department of Psychiatry, Yale Univesity, 06510-8068, New Haven, CT, USA

1. Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK

   M. Cador, J. R. Taylor & T. W. Robbins

1. M. Cador
2. J. R. Taylor
3. T. W. Robbins

Cador, M., Taylor, J.R. & Robbins, T.W. Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens. Psychopharmacology 104, 377–385 (1991). https://doi.org/10.1007/BF02246039

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• Received: 14 March 1990

• Revised: 03 December 1990

• Issue Date: September 1991

• DOI: https://doi.org/10.1007/BF02246039

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