6-Hydroxylation: An important metabolic route for α-methyltryptamine
ZusammenfassungDer Stoffwechsel der psychotropischen Verbindung α-Methyltryptamin wurde untersucht. Die drei hauptsächlichsten Metabolite wurdenin vitro undin vivo als 6-Hydroxy-α-methyltryptamin, 3-Indolylaceton und 6-Hydroxy-3-indolylaceton identifiziert.
Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. ReferencesH. B. Murphree, Jr., E. H. Jenney, andC. C. Pfeiffer, The Pharmacologist2, 64 (1960).
S. Szara, unpublished observation.
S. Szara, E. Hearst, andF. Putney, Fed. Proc.19, 23 (1960).
W. G. Van Meter, G. F. Ayala, E. Costa, andH. E. Himwich, Fed. Proc.19, 265 (1960).
M. E. Greig, R. A. Walk, andA. J. Gibbons, J. Pharm. exp. Therap.127, 110 (1959).
A. Yuwiler, E. Geller, andS. Eiduson, Arch. Biochem. Biophys.80, 162 (1959).
J. Axelrod, J. biol. Chem.214, 753 (1955).
J. B. Brown, H. B. Henbest, andE. R. H. Jones, J. chem. Soc.1952, 3172.
S. Szara andJ. Axelrod, Exper.15, 216 (1959).
Since we usedd, l-αMT (synthetized according to the method ofE. H. P. Young, J. chem. Soc.1958, 3496), it is very probable that the bulk of the unchanged compound is thel-isomer not attacked by the stereospecific enzyme (see Ref.7).
E. Hearst andS. Szara, Amer. Psychologist15, 476 (1960).
Clinical Neuropharmacology Research Center, Washington (D.C.)
S. Szara
Szara, S. 6-Hydroxylation: An important metabolic route for α-methyltryptamine. Experientia 17, 76 (1961). https://doi.org/10.1007/BF02171429
Published: 01 February 1961
Issue Date: February 1961
DOI: https://doi.org/10.1007/BF02171429
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4