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Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a New ‘false’ sympathetic transmitter

Le traitement de chats par la 5-hydroxydopamine (5-HDA), une amine agissant comme «faux» transmetteur sympathique, conduit à l'accumulation d'un matériel très osmiophile dans les vésicules des terminaisons sympathiques. Il a pu être démontré que ce matériel osmiophile représente principalement la 5-HDA. En même temps la teneur de la noradrénaline est fortement diminuée. Les vésicules des terminaisons nerveuses cholinergiques restent vides.

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1. H. Thoenen, W. Haefely, K. F. Gey andA. Hürlimann, Arch. exp. Path. Pharmak., in press.

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1. Department of experimental medicine, Hoffmann-La Roche & Co. Ltd, Basel, Switzerland

   J. P. Tranzer & H. Thoenen

1. J. P. Tranzer
2. H. Thoenen

Tranzer, J.P., Thoenen, H. Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a New ‘false’ sympathetic transmitter. Experientia 23, 743–745 (1967). https://doi.org/10.1007/BF02154151

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• Published: 01 September 1967

• Issue Date: September 1967

• DOI: https://doi.org/10.1007/BF02154151

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